Results 221 to 230 of about 13,460,861 (391)

Lactate Metabolic Reprogramming Mediated by CircRNA–LDHA Complex Facilitates Innate Immune Evasion of Liver Cancer

Advanced Science, EarlyView.
CircSMPD4 physically combines with lactate dehydrogenase A (LDHA) and reduces its acetylation level via SIRT2‐dependent deacetylation, thereby inhibiting chaperone‐mediated autophagy‐lysosome degradation of LDHA. Upregulating LDHA leads to increasing lactate production and extracellular export, which in turn suppresses natural killer cell cytotoxicity ...
Hao Shen, Boqiang Liu, Jing He, Weijun Zhao, Weiqi Li, Lingfeng Ma, Lidan Hou, Yi Wang, Chenqi Jin, Yushun Chang, Jie Lin, Jia Zhao, Binghan Jin, Yuanshi Tian, Xiujun Cai, Liang Shi, Yifan Wang   +16 more
wiley   +1 more source

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

Advanced Science, EarlyView.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong   +7 more
wiley   +1 more source

Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: Similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

, 2010
Stephanos Pavlides, Aristotelis Tsirigos, Iset Vera, Neal Flomenberg, Philippe G. Frank, Mathew C. Casimiro, Chenguang Wang, Richard G. Pestell, Ubaldo Martinez‐Outschoorn, Anthony Howell, Federica Sotgia, Michael P. Lisanti   +11 more
openalex   +1 more source

The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells [PDF]

, 2013
David G. Watson, Francesca Tonelli, Manal A. Alossaimi, Leon E. Williamson, Edmond Y. W. Chan, И. А. Горшкова, Evgeny Berdyshev, Robert Bittman, Nigel J. Pyne, Susan Pyne   +9 more
openalex   +1 more source

Impedances of electrochemically impregnated nickel electrodes as functions of potential, KOH concentration, and impregnation method [PDF]

Impedances of fifteen electrodes form each of the four U.S. manufactures were measured at 0.200 V vs. the Hg/HgO reference electrode. This corresponds to a voltage of 1.145 for a Ni/H2 cell. Measurements were also made of a representative sample of these
Reid, Margaret A.
core   +1 more source

SLC6A14 Drives Mitochondrial Fusion and Oxidative Phosphorylation to Promote Cancer Stemness and Early‐Onset of Breast Cancer

Advanced Science, EarlyView.
Elevated levels of the plasticizer DEHP associate with earlier breast cancer diagnosis. DEHP enhances glutamine‐powered energy production via the transporter SLC6A14 and pushes mitochondria toward fusion, driving tumor initiation by boosting cancer stemness. Blocking SLC6A14 lowers stemness, slows tumors, and improves chemotherapy response.
Dai‐Wei Hu, Chih‐Hao Huang, Yu‐Hao He, Ya‐Ling Wei, Shu‐Wei Hu, Fang‐Ju Cheng, Thanh Kieu Huynh, Bo‐Rong Chen, Bo‐Wei Wang, Li‐Chi Kuan, Der‐Yen Lee, Ming‐Hsin Yeh, Ya‐Jen Chang, Liang‐Chih Liu, Mien‐Chie Hung, Wei‐Chien Huang   +15 more
wiley   +1 more source

Deciphering enemy tactics - the narrow path to an optimal anti-cancer strategy targeting the Warburg effect. [PDF]

Pharmacol Rep
Kocemba-Pilarczyk KA, Ostrowska B, Trojan SE, Dudzik P.   +3 more
europepmc   +1 more source

p32 (C1QBP) and Cancer Cell Metabolism: Is the Warburg Effect a Lot of Hot Air?

, 2010
Chi V. Dang
openalex   +1 more source

Expression and phosphorylation of the AS160_v2 splice variant supports GLUT4 activation and the Warburg effect in multiple myeloma [PDF]

, 2013
Javelin C. Cheng, Samuel K. McBrayer, Cristian Coarfa, Sevim Dalva-Aydemir, Preethi H. Gunaratne, John D. Carpten, Jonathan J. Keats, Steven T. Rosen, Mala Shanmugam   +8 more
openalex   +1 more source

Lactate‐Modulating Nanoreactors Facilitate Self‐Amplifying Pyroptosis and the cGAS‐STING Cascade for Potentiated Catalytic‐Immunotherapy

Advanced Science, EarlyView.
An intelligent lactate‐depleting LOCoF2 (CoF2@LOx) nanoreactor system is developed to effectively induce self‐reinforced pyroptosis and activate the cGAS‐STING signaling pathway, thereby inducing a strong immune response and enhancing the therapeutic effectiveness of catalytic immunotherapy.
Linzhu Zhang, Shumin Sun, Duo Wang, Nailin Yang, Di Wang, Jihu Nie, Zifan Pei, Juan Qin, Lei Zhang, Haidong Zhu, Liang Cheng   +10 more
wiley   +1 more source