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The Warburg effect in 2012

Current Opinion in Oncology, 2012
A revival of interest in tumor metabolism is underway and here we discuss recent results with a focus on the central theme of the Warburg effect, aerobic glycolysis.The M2 tumor-specific isoform of pyruvate kinase has generated much interest, but it has now been reported that PKM2 is not specific to tumors.
Bayley, J.P., Devilee, P.
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Warburg Effect or Reverse Warburg Effect? A Review of Cancer Metabolism

Oncology Research and Treatment, 2015
Cancer is a major threat to human health. A considerable amount of research has focused on elucidating the nature of cancer from its pathogenesis to treatment and prevention. Tumor cell metabolism has been considered a hallmark of cancer. Cancer cells differ from normal cells through unlimited cell division, and show a greater need for energy for their
Xiao Dong, Xu   +8 more
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Warburg effect in Gynecologic cancers

Journal of Obstetrics and Gynaecology Research, 2018
AbstractMammalian cells produce energy by oxidative phosphorylation under aerobic conditions. However, in the 1920s, Otto Warburg reported the so‐called “Warburg effect” in which cancer cells produce ATP that is biased toward glycolysis rather than mitochondrial oxidative phosphorylation not only in anaerobic environment but also in aerobic environment.
Yusuke, Kobayashi   +8 more
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The Warburg Effect and the Hallmarks of Cancer

Anti-Cancer Agents in Medicinal Chemistry, 2017
It is a longstanding debate whether cancer is one disease or a set of very diverse diseases. The goal of this paper is to suggest strongly that most of (if not all) the hallmarks of cancer could be the consequence of the Warburg's effect. As a result of the metabolic impairment of the oxidative phosphorylation, there is a decrease in ATP concentration.
Schwartz, Laurent   +2 more
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From Warburg effect to Reverse Warburg effect; the new horizons of anti-cancer therapy

Medical Hypotheses, 2020
An old ideology of killing the cancer cells by starving them is the underlying concept of the Warburg effect. It is the process of aerobic glycolysis exhibited by the cancer cells irrespective of anaerobic glycolysis or mitochondrial oxidative phosphorylation following by their healthy counterparts.
Sonu, Benny   +3 more
openaire   +2 more sources

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