Results 311 to 320 of about 106,451 (346)
Some of the next articles are maybe not open access.
The Warburg effect: a signature of mitochondrial overload
Trends in Cell Biology, 2023A long-standing question in cancer biology has been why oxygenated tumors ferment the majority of glucose they consume to lactate rather than oxidizing it in their mitochondria, a phenomenon known as the 'Warburg effect.' An abundance of evidence shows not only that most cancer cells have fully functional mitochondria but also that mitochondrial ...
Yahui, Wang, Gary J, Patti
openaire +2 more sources
Understanding the Warburg Effect in Cancer
Cold Spring Harbor Perspectives in MedicineRapidly proliferating cells, including cancer cells, adapt metabolism to meet the increased energetic and biosynthetic demands of cell growth and division. Many rapidly proliferating cells exhibit increased glucose consumption and fermentation regardless of oxygen availability, a phenotype termed aerobic glycolysis or the Warburg effect in cancer ...
Zhaoqi Li +4 more
openaire +2 more sources
Warburg effect and its role in tumourigenesis
Archives of Pharmacal Research, 2019Glucose is a crucial molecule in energy production and produces different end products in non-tumourigenic- and tumourigenic tissue metabolism. Tumourigenic cells oxidise glucose by fermentation and generate lactate and adenosine triphosphate even in the presence of oxygen (Warburg effect).
Maphuti T. Lebelo +2 more
openaire +3 more sources
Hypoxia, glucose metabolism and the Warburg’s effect
Journal of Bioenergetics and Biomembranes, 2007As described by Warburg more than 50 years ago, tumour cells maintain a high glycolytic rate even in conditions of adequate oxygen supply. However, most of tumours are subjected to hypoxic conditions due to the abnormal vasculature that supply them with oxygen and nutrients. Thus, glycolysis is essential for tumour survival and spread.
Ramon, Bartrons, Jaime, Caro
openaire +2 more sources
A century of the Warburg effect
Nature Metabolism, 2023Craig B. Thompson +10 more
openaire +2 more sources
Chronic lymphocytic leukemia and the Warburg effect
Blood, 2015In this issue of Blood, Jitschin et al demonstrate a microenvironmental glycolytic shift in chronic lymphocytic leukemia (CLL) cells mediated by Notch-c-Myc signaling. Interfering in the Notch-c-Myc pathway and reprogramming glycolytic metabolism could contribute to overcoming drug resistance in CLL.
openaire +2 more sources
Cellular life span and the Warburg effect
Experimental Cell Research, 2008Enhanced glycolysis is observed in most of cancerous cells and tissues, called as the Warburg effect. Recent advance in senescent biology implicates that the metabolic shift to enhanced glycolysis would be involved in the early stage during multi-step tumorigenesis in vivo.
openaire +2 more sources
Warburg Effect Reshapes Tumor Immunogenicity
Cancer ResearchAbstract Tumor cells rewire their metabolism to fulfill the demands of highly proliferative cells. This changes cellular metabolism to adapt to fuel and oxygen availability for energy production and to increase the synthesis capacity of building blocks for cell division and growth.
José A. Enríquez, María Mittelbrunn
openaire +3 more sources
Warburg and Krebs and related effects in cancer
Expert Reviews in Molecular Medicine, 2019AbstractWarburg and coworkers' observation of altered glucose metabolism in tumours has been neglected for several decades, which, in part, was because of an initial misinterpretation of the basis of their finding. Following the realisation that genetic alterations are often linked to metabolism, and that the tumour micro-environment imposes different ...
Judith E. Unterlass, Nicola J. Curtin
openaire +3 more sources
Modulating Autophagy and the “Reverse Warburg Effect”
2014Autophagy is a highly regulated cellular pathway for degrading long-lived proteins and is the only known pathway for clearing cytoplasmic organelles. Autophagy is a major contributor to maintain cellular homeostasis and metabolism. The quality control of mitochondria is essential to maintain cell energy and this process appears to be achieved via ...
Vaccaro, Maria Ines +3 more
openaire +2 more sources