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Warburg Effect or Reverse Warburg Effect? A Review of Cancer Metabolism
Oncology Research and Treatment, 2015Cancer is a major threat to human health. A considerable amount of research has focused on elucidating the nature of cancer from its pathogenesis to treatment and prevention. Tumor cell metabolism has been considered a hallmark of cancer. Cancer cells differ from normal cells through unlimited cell division, and show a greater need for energy for their
Xiao Dong, Xu +8 more
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Warburg effect in Gynecologic cancers
Journal of Obstetrics and Gynaecology Research, 2018AbstractMammalian cells produce energy by oxidative phosphorylation under aerobic conditions. However, in the 1920s, Otto Warburg reported the so‐called “Warburg effect” in which cancer cells produce ATP that is biased toward glycolysis rather than mitochondrial oxidative phosphorylation not only in anaerobic environment but also in aerobic environment.
Yusuke, Kobayashi +8 more
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Current Opinion in Oncology, 2012
A revival of interest in tumor metabolism is underway and here we discuss recent results with a focus on the central theme of the Warburg effect, aerobic glycolysis.The M2 tumor-specific isoform of pyruvate kinase has generated much interest, but it has now been reported that PKM2 is not specific to tumors.
Bayley, J.P., Devilee, P.
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A revival of interest in tumor metabolism is underway and here we discuss recent results with a focus on the central theme of the Warburg effect, aerobic glycolysis.The M2 tumor-specific isoform of pyruvate kinase has generated much interest, but it has now been reported that PKM2 is not specific to tumors.
Bayley, J.P., Devilee, P.
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From Warburg effect to Reverse Warburg effect; the new horizons of anti-cancer therapy
Medical Hypotheses, 2020An old ideology of killing the cancer cells by starving them is the underlying concept of the Warburg effect. It is the process of aerobic glycolysis exhibited by the cancer cells irrespective of anaerobic glycolysis or mitochondrial oxidative phosphorylation following by their healthy counterparts.
Sonu, Benny +3 more
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Warburg Effect Reshapes Tumor Immunogenicity
Cancer ResearchAbstract Tumor cells rewire their metabolism to fulfill the demands of highly proliferative cells. This changes cellular metabolism to adapt to fuel and oxygen availability for energy production and to increase the synthesis capacity of building blocks for cell division and growth.
José A. Enríquez, María Mittelbrunn
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Warburg Effect and Redox Balance
Science, 2011A glycolytic enzyme maintains cellular redox homeostasis during metabolic stress.
Robert B. Hamanaka, Navdeep S. Chandel
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Understanding the Warburg Effect in Cancer
Cold Spring Harbor Perspectives in MedicineRapidly proliferating cells, including cancer cells, adapt metabolism to meet the increased energetic and biosynthetic demands of cell growth and division. Many rapidly proliferating cells exhibit increased glucose consumption and fermentation regardless of oxygen availability, a phenotype termed aerobic glycolysis or the Warburg effect in cancer ...
Zhaoqi Li +4 more
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Warburg effect and its role in tumourigenesis
Archives of Pharmacal Research, 2019Glucose is a crucial molecule in energy production and produces different end products in non-tumourigenic- and tumourigenic tissue metabolism. Tumourigenic cells oxidise glucose by fermentation and generate lactate and adenosine triphosphate even in the presence of oxygen (Warburg effect).
Maphuti T. Lebelo +2 more
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Hypoxia, glucose metabolism and the Warburg’s effect
Journal of Bioenergetics and Biomembranes, 2007As described by Warburg more than 50 years ago, tumour cells maintain a high glycolytic rate even in conditions of adequate oxygen supply. However, most of tumours are subjected to hypoxic conditions due to the abnormal vasculature that supply them with oxygen and nutrients. Thus, glycolysis is essential for tumour survival and spread.
Ramon, Bartrons, Jaime, Caro
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New Compound Targets Warburg Effect
Cancer Discovery, 2015Abstract Researchers have developed a compound, SR9243, that kills cancer cells by inhibiting lipid production and the Warburg effect. The drug induces cell death in multiple types of cancer and does not cause the side effects that have derailed previous attempts to target these processes.
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