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Chronic lymphocytic leukemia and the Warburg effect

Blood, 2015
In this issue of Blood, Jitschin et al demonstrate a microenvironmental glycolytic shift in chronic lymphocytic leukemia (CLL) cells mediated by Notch-c-Myc signaling. Interfering in the Notch-c-Myc pathway and reprogramming glycolytic metabolism could contribute to overcoming drug resistance in CLL.
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Cellular life span and the Warburg effect

Experimental Cell Research, 2008
Enhanced glycolysis is observed in most of cancerous cells and tissues, called as the Warburg effect. Recent advance in senescent biology implicates that the metabolic shift to enhanced glycolysis would be involved in the early stage during multi-step tumorigenesis in vivo.
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Modulating Autophagy and the “Reverse Warburg Effect”

2014
Autophagy is a highly regulated cellular pathway for degrading long-lived proteins and is the only known pathway for clearing cytoplasmic organelles. Autophagy is a major contributor to maintain cellular homeostasis and metabolism. The quality control of mitochondria is essential to maintain cell energy and this process appears to be achieved via ...
Vaccaro, Maria Ines +3 more
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Warburg Effect

2008
Chi V. Dang, Ping Gao, Jung-whan Kim
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A century of the Warburg effect