Results 351 to 360 of about 13,486,463 (390)

The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression

International Journal of Radiation Biology, 2019
In the early 1920s, Warburg published experimental data on the enhanced conversion of glucose to pyruvate (followed by lactate formation) even in the presence of abundant oxygen (aerobic glycolysis, Warburg effect).
P. Vaupel, H. Schmidberger, A. Mayer
semanticscholar   +1 more source

Inversion of the Warburg Effect: Unraveling the Metabolic Nexus between Obesity and Cancer.

ACS Pharmacology & Translational Science
Obesity is a well-established risk factor for cancer, significantly impacting both cancer incidence and mortality. However, the intricate molecular mechanisms connecting adipose tissue to cancer cell metabolism are not fully understood.
Reshmi Akter, Muhammad Awais, Vinothini Boopathi, J. Ahn, D. Yang, Sera Kang, Dong-Uk Yang, Seok-Kyu Jung   +7 more
semanticscholar   +1 more source

Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer

Expert Review of Molecular Diagnostics, 2022
Introduction Adaptations of eukaryotic cells to environmental changes are important for their survival. However, under some circumstances, microenvironmental changes promote that eukaryotic cells utilize a metabolic signature resembling a unicellular ...
G. Nava, Luis Alberto Madrigal Perez
semanticscholar   +1 more source

Warburg and Krebs and related effects in cancer [PDF]

Expert Reviews in Molecular Medicine, 2019
AbstractWarburg and coworkers' observation of altered glucose metabolism in tumours has been neglected for several decades, which, in part, was because of an initial misinterpretation of the basis of their finding. Following the realisation that genetic alterations are often linked to metabolism, and that the tumour micro-environment imposes different ...
Judith E. Unterlass, Nicola J. Curtin
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Warburg Effect and Redox Balance

Science, 2011
A glycolytic enzyme maintains cellular redox homeostasis during metabolic stress.
Navdeep S. Chandel, Robert B. Hamanaka
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Hypoxia, glucose metabolism and the Warburg’s effect

Journal of Bioenergetics and Biomembranes, 2007
As described by Warburg more than 50 years ago, tumour cells maintain a high glycolytic rate even in conditions of adequate oxygen supply. However, most of tumours are subjected to hypoxic conditions due to the abnormal vasculature that supply them with oxygen and nutrients. Thus, glycolysis is essential for tumour survival and spread.
Jaime Caro, Ramon Bartrons
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Chronic lymphocytic leukemia and the Warburg effect

Blood, 2015
In this issue of Blood, Jitschin et al demonstrate a microenvironmental glycolytic shift in chronic lymphocytic leukemia (CLL) cells mediated by Notch-c-Myc signaling. Interfering in the Notch-c-Myc pathway and reprogramming glycolytic metabolism could contribute to overcoming drug resistance in CLL.
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Warburg effect and its role in tumourigenesis

Archives of Pharmacal Research, 2019
Glucose is a crucial molecule in energy production and produces different end products in non-tumourigenic- and tumourigenic tissue metabolism. Tumourigenic cells oxidise glucose by fermentation and generate lactate and adenosine triphosphate even in the presence of oxygen (Warburg effect).
Maphuti T. Lebelo, Anna M. Joubert, Michelle H. Visagie   +2 more
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Warburg Effect Reshapes Tumor Immunogenicity

Cancer Research
Abstract Tumor cells rewire their metabolism to fulfill the demands of highly proliferative cells. This changes cellular metabolism to adapt to fuel and oxygen availability for energy production and to increase the synthesis capacity of building blocks for cell division and growth.
José A. Enríquez, María Mittelbrunn
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Cellular life span and the Warburg effect

Experimental Cell Research, 2008
Enhanced glycolysis is observed in most of cancerous cells and tissues, called as the Warburg effect. Recent advance in senescent biology implicates that the metabolic shift to enhanced glycolysis would be involved in the early stage during multi-step tumorigenesis in vivo.
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