Results 61 to 70 of about 13,460,861 (391)

Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial priming. [PDF]

, 2016
The impact of EGFR-mutant NSCLC precision therapy is limited by acquired resistance despite initial excellent response. Classic studies of EGFR-mutant clinical resistance to precision therapy were based on tumor rebiopsies late during clinical tumor ...
Bagai, Rakesh, Bivona, Trever G, Danielpour, David, Feng, Yan, Leahy, Patrick, Lindner, Daniel, Ma, Patrick C, Rosell, Rafael, Shi, Ivy, Thiagarajan, Praveena S, Veigl, Martina, Wu, Xiaoliang, Yin, Lihong, Zhang, Wei, Zhang, Zhenfeng   +14 more
core   +1 more source

Uncoupling the Warburg effect from cancer [PDF]

Proceedings of the National Academy of Sciences, 2010
A remarkable trademark of most tumors is their ability to break down glucose by glycolysis at a vastly higher rate than in normal tissues, even when oxygen is copious. This phenomenon, known as the Warburg effect, enables rapidly dividing tumor cells to generate essential biosynthetic building blocks such as nucleic acids, amino acids, and lipids from ...
Najafov, Ayaz, Alessi, Dario R.
openaire   +4 more sources

Unmasking the Warburg Effect: Unleashing the Power of Enzyme Inhibitors for Cancer Therapy

Drugs and Drug Candidates, 2023
The Warburg effect (or aerobic glycolysis), which was first described in 1926 by Otto Heinrich Warburg, consists of the change in glucose metabolism in cancer cells.
Eduardo Angulo-Elizari, Leire Gaviria-Soteras, Irati Zubiri, Sandra Ramos-Inza, Carmen Sanmartin, Daniel Plano   +5 more
doaj   +1 more source

MNX1-AS1, a c-Myc induced lncRNA, promotes the Warburg effect by regulating PKM2 nuclear translocation

Journal of experimental & clinical cancer research : CR, 2022
Background Altered glycolysis is the most fundamental metabolic change associated with the Warburg effect. Some glycolytic enzymes such as PKM2, the dominant pyruvate kinase in cancer cells, have been shown to engage in non-glycolytic functions that ...
Yang Wu, Yichun Wang, H. Yao, Heng Li, F. Meng, Qidong Li, Xiansheng Lin, Lianxin Liu   +7 more
semanticscholar   +1 more source

The Non-Ideal Organic Electrochemical Transistors Impedance [PDF]

, 2019
Organic electrochemical transistors offer powerful functionalities for biosensors and neuroinspired electronics, with still much to understand on the time dependent behavior of this electrochemical device.
Crljen, Željko, Lončaric, Ivor, Pecqueur, Sébastien, Vuillaume, Dominique, Zlatić, Vinko   +4 more
core   +2 more sources

Tyrosine Kinase Signaling in Cancer Metabolism: PKM2 Paradox in the Warburg Effect

Frontiers in Cell and Developmental Biology, 2018
The Warburg Effect, or aerobic glycolysis, is one of the major metabolic alterations observed in cancer. Hypothesized to increase a cell's proliferative capacity via regenerating NAD+, increasing the pool of glycolytic biosynthetic intermediates, and ...
Elizabeth K. Wiese, Elizabeth K. Wiese, Taro Hitosugi, Taro Hitosugi   +3 more
doaj   +1 more source

Genetic Mutations and Non-Coding RNA-Based Epigenetic Alterations Mediating the Warburg Effect in Colorectal Carcinogenesis

Biology, 2021
Colorectal cancer (CRC) development is a gradual process defined by the accumulation of numerous genetic mutations and epigenetic alterations leading to the adenoma-carcinoma sequence.
Batoul Abi Zamer, Wafaa Abumustafa, Mawieh Hamad, Azzam A. Maghazachi, Jibran Sualeh Muhammad   +4 more
doaj   +1 more source

NCAPD3 enhances Warburg effect through c-myc and E2F1 and promotes the occurrence and progression of colorectal cancer

Journal of experimental & clinical cancer research : CR, 2022
Background NCAPD3 is one of the three non-SMC subunits of condensin II complex, which plays an important role in the chromosome condensation and segregation during mitosis. Notably, elevated levels of NCAPD3 are found in many somatic cancers.
Zuolei Jing, Qianmei Liu, Xinyuan He, Zhirong Jia, Zhi-peng Xu, Bolin Yang, Ping Liu   +6 more
semanticscholar   +1 more source

Postulates on electromagnetic activity in biological systems and cancer [PDF]

, 2013
A framework of postulates is formulated to define the existence, nature, and function of a coherent state far from thermodynamic equilibrium in biological systems as an essential condition for the existence of life. This state is excited and sustained by
Alberts, Albrecht-Buehler, Albrecht-Buehler, Amos, Amos, Baker, Beil, Bonnet, Chen, Damadian, Dehmelt, Del Giudice, Devlin, Fröhlich, Fröhlich, Fröhlich, Fröhlich, Fuchs, Guck, Hagan, Hameroff, Hölzel, Jan Pokorný, Jandová, Jandová, Jelínek, Jitka Kobilková, Jiří Pokorný, Kirson, Kwapień, Michelakis, Michor, Nakamura, Nakamura, Pavlides, Pelling, Penrose, Pohl, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Popp, Preparata, Priel, Sahu, Sahu, Seyfried, Toyokuni, Traill, Tuszyński, Tyner, Vedruccio, Wada, Wada, Warburg, Warburg, Yamada, Zheng   +69 more
core   +1 more source

Fundamentals of the Warburg Effect in Cancer [PDF]

Journal of Nutritional Oncology, 2019
Abstract: As the fundamental energy unit of most cells, the ATP generated from glucose is vital to maintain biological processes such as the synthesis of proteins and nucleic acids. However, a common feature of cancer cells is an altered metabolism with increased glucose uptake and the fermentation of glucose to lactate even in
Ya Qi Xing, Pi Xian Zhang, Yong Dong Niu
openaire   +1 more source