Results 61 to 70 of about 678,174 (319)
PLoS Pathogens, 2014 In this study, we used a systems biology approach to investigate changes in the proteome and metabolome of shrimp hemocytes infected by the invertebrate virus WSSV (white spot syndrome virus) at the viral genome replication stage (12 hpi) and the late ...
Mei-An Su +15 more
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Overflow metabolism originates from growth optimization and cell heterogeneity [PDF]
arXiv, 2023 A classic problem in metabolism is that fast-proliferating cells use seemingly wasteful fermentation for energy biogenesis in the presence of sufficient oxygen. This counterintuitive phenomenon, known as overflow metabolism or the Warburg effect, is universal across various organisms.
arxiv
Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle [PDF]
Scientific Reports 5, 11880 (2015), 2015 Cancer cells utilize large amounts of ATP to sustain growth, relying primarily on non-oxidative, fermentative pathways for its production. In many types of cancers this leads, even in the presence of oxygen, to the secretion of carbon equivalents (usually in the form of lactate) in the cell's surroundings, a feature known as the Warburg effect.
arxiv +1 more source
Blood, 2018 Abstract Mature B cells recognize and respond in a highly-specific fashion to a multitude of environmental antigens through membrane-bound immunoglobulins forming together with the Igα and Igβ proteins a functional unit called the B cell antigen receptor (BCR).
Federica Zanardi +11 more
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Warburg effect—damping of electromagnetic oscillations [PDF]
Electromagnetic Biology and Medicine, 2017 Mitochondrial dysfunction is a central defect in cells creating the Warburg and reverse Warburg effect cancers. However, the link between mitochondrial dysfunction and cancer has not yet been clearly explained. Decrease of mitochondrial oxidative energy production to about 50 % in comparison with healthy cells may be caused by inhibition of pyruvate ...
Jiří Pokorný +2 more
openaire +3 more sources
Frontiers in Pharmacology, 2019 The Warburg effect is a peculiar feature of cancer’s metabolism, which is an attractive therapeutic target that could aim tumor cells while sparing normal tissue.
Xiaoting Hong +15 more
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Correlation between the Warburg effect and progression of triple-negative breast cancer
Frontiers in Oncology, 2023 Triple-negative breast cancer (TNBC) is ineligible for hormonal therapy and Her-2-targeted therapy due to the negative expression of the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2. Although targeted therapy and
Shaojun Liu +4 more
doaj +1 more source
THE WARBURG EFFECT AND BEYOND [PDF]
Neuro-Oncology, 2014 BACKGROUND: Pyruvate kinase M2 (PKM2) is highly expressed in multiple cancer types and contributes to the Warburg effect. METHODS: We have used various approaches including animal studies, human GBM specimen analyses, and biochemical studies, to understand the cellular functions of PKM2.
openaire +2 more sources
Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. [PDF]
PLoS ONE, 2015 Previously we have generated inducible liver tumor models by transgenic expression of Myc or xmrk (activated EGFR homolog) oncogenes in zebrafish. To investigate the interaction of the two oncogenes, we crossed the two transgenic lines and observed more ...
Zhen Li +4 more
doaj +1 more source
Global Stability of a PDE-ODE model for acid-mediated tumor invasion [PDF]
arXiv, 2023 In this paper, we study the global dynamics of a general reaction-diffusion model based on acid-mediated invasion hypothesis, which is a candidate explanation for the Warburg effect. A key feature of this model is the density-limited tumor diffusion term for tumor cells, which might give rise to the degeneracy of the parabolic equation. Our theoretical
arxiv