Results 61 to 70 of about 106,451 (346)

Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

Acta Pharmaceutica Sinica B
Cancer reprogramming is an important facilitator of cancer development and survival, with tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation, even under sufficient oxygen supply condition.
Minru Liao, Dahong Yao, Lifeng Wu, Chaodan Luo, Zhiwen Wang, Jin Zhang, Bo Liu   +6 more
doaj   +1 more source

Heterogeneity and proliferation of invasive cancer subclones in game theory models of the Warburg effect [PDF]

, 2015
OBJECTIVES: The Warburg effect, the switch from aerobic energy production to anaerobic glycolysis, promotes tumour proliferation and motility by inducing acidification of the tumour microenvironment.
Archetti, Archetti, Archetti, Archetti, Archetti, Archetti, Bach, Basanta, Basanta, Basanta, Bergers, Bhujwalla, Buchler, Casciari, Feron, Gambhir, Gatenby, Gatenby, Gatenby, Gatenby, Gillies, Griffiths, Hanahan, He, Ibrahim Hashim, Ibrahim Hashim, Kelloff, Kianercy, Kunkel, Lardner, Martin, Martin, Maynard Smith, Mochiki, Park, Patel, Pauwels, Perc, Postovit, Postovit, Rajendran, Robey, Rohzin, Rubin, Schornack, Semenza, Shi, Silva, Smallbone, Smallbone, Sonveaux, Tomlinson, Tomlinson, Warburg, Williams, Wojtkowiak   +55 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Effects of Nanoparticle Geometry and Size Distribution on Diffusion Impedance of Battery Electrodes

, 2012
The short diffusion lengths in insertion battery nanoparticles render the capacitive behavior of bounded diffusion, which is rarely observable with conventional larger particles, now accessible to impedance measurements. Coupled with improved geometrical
Bazant, M. Z., Song, J.
core   +1 more source

The Non-Ideal Organic Electrochemical Transistors Impedance [PDF]

, 2019
Organic electrochemical transistors offer powerful functionalities for biosensors and neuroinspired electronics, with still much to understand on the time dependent behavior of this electrochemical device.
Crljen, Željko, Lončaric, Ivor, Pecqueur, Sébastien, Vuillaume, Dominique, Zlatić, Vinko   +4 more
core   +2 more sources

Reversing the Warburg Effect as a Treatment for Glioblastoma [PDF]

Journal of Biological Chemistry, 2013
Glioblastoma multiforme (GBM), like most cancers, possesses a unique bioenergetic state of aerobic glycolysis known as the Warburg effect. Here, we documented that methylene blue (MB) reverses the Warburg effect evidenced by the increasing of oxygen consumption and reduction of lactate production in GBM cell lines.
Ethan, Poteet, Gourav Roy, Choudhury, Ali, Winters, Wenjun, Li, Myoung-Gwi, Ryou, Ran, Liu, Lin, Tang, Anuja, Ghorpade, Yi, Wen, Fang, Yuan, Stephen T, Keir, Hai, Yan, Darell D, Bigner, James W, Simpkins, Shao-Hua, Yang   +14 more
openaire   +2 more sources

Multi‐Omics Integration for Advancing Glioma Precision Medicine

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas are among the most malignant and aggressive tumors of the central nervous system, characterized by the absence of early diagnostic markers, poor prognosis, and a lack of effective treatments. Advances in high‐throughput technologies have facilitated a refined molecular classification of gliomas, incorporating genetic features. However,
Maria Guarnaccia, Valentina La Cognata, Giulia Gentile, Giovanna Morello, Sebastiano Cavallaro   +4 more
wiley   +1 more source

Lactic Acidosis and Hypoglycemia in a Patient with Gastric Diffuse Large B-Cell Lymphoma due to the Warburg Effect

Case Reports in Oncology, 2020
Lactic acidosis is pathophysiologically classified into type A and type B. The latter is a rare but potentially life-threatening emergency, mainly described in hematological malignancies.
Takafumi Hamada, Toshinari Kaku, Sumitaka Mitsu, Yoshinori Morita, Nobuhito Ohno, Hironori Yamaguchi   +5 more
doaj   +1 more source

CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR‐433‐3p in non‐small cell lung cancer

Thoracic Cancer, 2022
Background Circular RNAs (circRNAs) participate in the genesis and progression of tumors, including non‐small cell lung cancer (NSCLC). At present, the role and regulatory mechanisms of circRNAs in NSCLC have not been fully elucidated.
Jia Yu, Haining Zhang, Chunsheng Zhao, Guanghui Li, Yingying Zhang, Yang Sun   +5 more
doaj   +1 more source

Warburg effect: cancer cells metabolism [PDF]

, 2011
Prva istraživanja energetskog metabolizma tumora provodila su se 1922. godine u laboratoriju Otto Warburga. Warburg je ustanovio specifičan metabolizam stanica raka čija je karakteristika prijelaz s respiracije na fermentaciju - nazvan je Warburg-ov ...
Križnik, Bojana
core   +2 more sources