Results 101 to 110 of about 76,947 (296)
Tissue-Specific Chk1 Activation Determines Apoptosis by Regulating the Balance of p53 and p21
iScience, 2019 Summary: The DNA damage response (DDR) protects cells against genomic instability. Surprisingly, little is known about the differences in DDR across tissues, which may affect cancer evolutionary trajectories and chemotherapy response.
Marijn T.M. van Jaarsveld +3 more
doaj +1 more source
A “Grey Savior”: Kenneth Clark and the rescue of Hamburg’s Warburg Institute
, 2021 Kenneth Clark (1903-1983), an art historian, was a leading public intellectual of mid-20th century Britain. Clark was a key figure in the effective transplantation of Hamburg's Warburg Institute to London. Clark perceived the intellectual approach of Aby Warburg (1866-1929), who championed the contextualization of symbolism, as more historically sound ...
openaire +3 more sources
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Incontri: Rivista Europea di Studi ItalianiLe gioie della duchessa: due inventari inediti di Lucrezia Borgia Questo articolo presenta la trascrizione completa integrata di commento di due inventari di gioie di Lucrezia Borgia d’Este (1480-1519), datati 20 aprile 1515 e finora passati ...
Carlotta Gonzi
doaj +1 more source
The biological synthesis of hippuric acid in vitro [PDF]
, 1940 The mechanism of the synthesis of hippuric acid in viva is interesting from several points of view. There is the intrinsic interest in a compound found in the urine of many animals, an interest which is heightened by the use of the rate of hippuric acid ...
Borsook, Henry, Dubnoff, Jacob W.
core
Hyperbolic subdiffusive impedance
, 2008 We use the hyperbolic subdiffusion equation with fractional time derivatives (the generalized Cattaneo equation) to study the transport process of electrolytes in media where subdiffusion occurs.
Cabeza M +12 more
core +1 more source
Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation
Advanced Science, EarlyView.An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng +10 more
wiley +1 more source
Lithiophilic Current Collector Without Interfacial Penalty in Zero‐Excess Lithium Metal Batteries
Advanced Science, EarlyView.Bilayer lithiophilic coatings are introduced to overcome the structural fragility of conventional single‐layer current collectors in zero‐excess Li‐metal batteries (ZE‐LMBs). By integrating density functional theory with electrochemical analyses, the Ag‐outer/Pt‐inner configuration enables uniform Li deposition, robust SEI formation, and persistent ...
Jiyeon Seo +8 more
wiley +1 more source
Al-Qantara : Revista de Estudios Arabes, 2016 Como continuación a estudios anteriores sobre la recepción de las Rasā’il Ijwān al-Ṣafā’ en al-Andalus, en este artículo se sostiene que entre los estudiosos andalusíes de la Edad Media era una creencia generalizada considerar al astrónomo Maslama al ...
Godefroid de Callataÿ +1 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei +11 more
wiley +1 more source