Results 111 to 120 of about 76,947 (296)

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Machine‐Learning Microfluidic Minute‐Scale Microorganism Metrics Monitoring(M6)

Advanced Science, EarlyView.
ABSTRACT On‐site monitoring of microorganisms remains challenging because of low concentrations, strong background interference, and dynamic aerosol diffusion, particularly for aerosol‐transmitted pathogens. Here, we report a rapid detection platform that integrates a Puri‐focusing microfluidic chip, electrochemical impedance spectroscopy (EIS), and ...
Ning Yang, Jiahao Ding, Si Chen, Lijie Yan, Shichao Ding, Lavonda Li, Junyi Sun, Haodong Liu, Tongge Li, Ning Liu, Mingji Wei, Xiaoyong Zhu, Xiaobo Zou, Shouqi Yuan, Xingcai Zhang   +14 more
wiley   +1 more source

Synergistic Ion Transport and Spatial Confinement in Sb‐Embedded Hollow Carbon Nanofibers for Stable Na Metal Anodes

Advanced Science, EarlyView.
This work presents a 3D Sb‐embedded hollow carbon nanofiber (Sb@HCF) host for ultra‐stable Na metal anodes. Experimental analyses and theoretical simulations clearly uncovers that in situ formed Na‐Sb alloy guides uniform Na deposition and serves as efficient ion transport highways. The Sb@HCF‐based cells achieve exceptional cycling stability in half‐,
Feng Han, Menghuan Yuan, Hui Wang, Baitao Liu, Dezhi Kong, Yongtao Tian, Xinjian Li, Ye Wang, Tingting Xu, Hui Ying Yang   +9 more
wiley   +1 more source

Philosophy and Pedagogy in Horace Epistles I

New Classicists, 2021
The conventional system of education, enkyklios paideia, was formalised in the Hellenistic period and to a large extent remained fixed throughout antiquity.
George Brocklehurst
doaj  

Printable Conductive Hydrogels for Electrochemical Biosensing and Soft Bioelectronic Interfaces

Advanced Science, EarlyView.
Flexible, conductive hydrogels that integrate printability, mechanical tunability, biocompatibility, and electronic performance remain challenging to achieve. Here, we develop 3D‐printable poly(ethylene glycol)–poly(pyrrole)‐ hydrogels with tissue‐like mechanics, high cytocompatibility, and robust electrochemical function.
Lukas Hein, Renan Colucci, Xin Wei, Tsvetomir Ivanov, Katharina Landfester, Ulrike Kraft, Maria Villiou   +6 more
wiley   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Crucified upon metals and alphabets: alchemical iconography of the sixteenth-century illustrated treatises by Martin Sturtz

BJHS Themes
This paper addresses the links between alchemy, mining and religion in the early modern alchemical iconography of the German mining theorist Martin Sturtz.
Sergei Zotov
doaj   +1 more source

Interviews with Michael Baxandall, February 3rd and 4th, 1994, Berkeley, CA [PDF]

Journal of Art Historiography, 2009
The following interviews with Michael Baxandall were conducted in Berkeley on February 3rd and 4th of 1994. The content of these interviews include general responses about developments in art history in the years between 1960 and 1985, a period of ...
Allan Langdale
doaj  

Self‐Assisted Charge Storage‐Release Mechanism Enabling Flexible Design of Biomimetic Triboelectric Nanogenerators

Advanced Science, EarlyView.
Inspired by the mimosa, this study develops a flexible triboelectric nanogenerator with a novel microneedle array and battery‐mimetic architecture. The device introduces a spontaneous charge self‐regulation mechanism that confines the electric field below the air breakdown threshold, and achieves an outstanding charge density of 396.50 µC m−2 ...
Hanpeng Gao, Yamin Hu, Li Li, Ana Sofia Oliveira Henriques Moita, Xi Wang, Zong Meng, Zhiwu Han, Yan Liu   +7 more
wiley   +1 more source

El espacio filológico

Revista Chuy, 2020
El presente artículo describe, sistematiza, analiza y expone el aporte disciplinario de Héctor Ciocchini y el Instituto de Humanidades de la Universidad Nacional del Sur.
Maximiliano Crespi
doaj