Results 111 to 120 of about 192,309 (409)

Comparative effectiveness and safety of extended anticoagulant therapy among Medicare beneficiaries with venous thromboembolism

Clinical and Translational Science, Volume 16, Issue 1, Page 128-139, January 2023., 2023
Abstract Guidelines recommend an extended course of anticoagulation therapy for patients who experienced venous thromboembolism (VTE) without transient provocation, however, optimal duration remains uncertain. We assessed effectiveness and safety of extended use of apixaban and warfarin greater than 6 months of initial treatment in patients with VTE ...
Haesuk Park, Hye‐Rim Kang, Pei‐Lin Huang, Wei‐Hsuan Lo‐Ciganic, Christina E. DeRemer, Debbie Wilson, Eric A. Dietrich   +6 more
wiley   +1 more source

Development of a Machine Learning Model and Mobile Application to Aid in Predicting Dosage of Vitamin K Antagonists Among Indian Patients [PDF]

arXiv, 2020
Patients who undergo mechanical heart valve replacements or have conditions like Atrial Fibrillation have to take Vitamin K Antagonists (VKA) drugs to prevent coagulation of blood. These drugs have narrow therapeutic range and need to be very closely monitored due to life threatening side effects.
arxiv  

Fair Exploration via Axiomatic Bargaining [PDF]

arXiv, 2021
Exploration is often necessary in online learning to maximize long-term reward, but it comes at the cost of short-term 'regret'. We study how this cost of exploration is shared across multiple groups. For example, in a clinical trial setting, patients who are assigned a sub-optimal treatment effectively incur the cost of exploration.
arxiv  

Ensemble of machine learning algorithms using the stacked generalization approach to estimate the warfarin dose

PLoS ONE, 2018
Warfarin dosing remains challenging due to narrow therapeutic index and highly individual variability. Incorrect warfarin dosing is associated with devastating adverse events.
Zhiyuan Ma, Ping Wang, Zehui Gao, Ruobing Wang, K. Khalighi   +4 more
semanticscholar   +1 more source

Visible‐Light Photocatalysis for Sustainable Chromene Synthesis and Functionalization

Chemistry – A European Journal, EarlyView.
Visible‐light photocatalysis provides sustainable and versatile methods for the synthesis and functionalization of chromene derivatives. This review compiles cutting‐edge methodologies, highlighting transformations such as multicomponent reactions, cross‐dehydrogenative coupling reactions, diverse cascade processes, and Giese‐type additions.
Paula Pérez‐Ramos, Georgia Biniari, Raquel G. Soengas, Humberto Rodríguez‐Solla, Carmen Simal   +4 more
wiley   +1 more source

Online Learning to Estimate Warfarin Dose with Contextual Linear Bandits [PDF]

arXiv, 2019
Warfarin is one of the most commonly used oral blood anticoagulant agent in the world, the proper dose of Warfarin is difficult to establish not only because it is substantially variant among patients, but also adverse even severe consequences of taking an incorrect dose.
arxiv  

Semi-Markov Offline Reinforcement Learning for Healthcare [PDF]

arXiv, 2022
Reinforcement learning (RL) tasks are typically framed as Markov Decision Processes (MDPs), assuming that decisions are made at fixed time intervals. However, many applications of great importance, including healthcare, do not satisfy this assumption, yet they are commonly modelled as MDPs after an artificial reshaping of the data.
arxiv  

Analysis of free analyte fractions by rapid affinity chromatography [PDF]

, 2004
The invention is generally directed toward an analytical method to determine the concentration of the free analyte fraction in a sample. More particularly, the method encompasses applying a sample comprising a free and bound analyte fraction to an ...
Clarke, William A., Hage, David S.
core   +1 more source

Stroke genetics: prospects for personalized medicine. [PDF]

, 2012
Epidemiologic evidence supports a genetic predisposition to stroke. Recent advances, primarily using the genome-wide association study approach, are transforming what we know about the genetics of multifactorial stroke, and are identifying novel stroke ...
A Gschwendtner, A Hassan, A Helgadottir, A Helgadottir, A Joutel, A Viswanathan, AB Singleton, AJ Bowes, AV Shirodkar, B Rohrer, C Bellenguez, CAPRIE Steering Committee, CS Ku, D Sibbing, DF Gudbjartsson, DJ Klionsky, DK Wysowski, DL Bhatt, DR Holmes Jr, DS Budnitz, E Flossmann, G Paré, HC Diener, HS Markus, HS Markus, Hugh S Markus, J Hardy, JA Johnson, JB Olesen, JF Meschia, JL Mega, JN Hirschhorn, JT O'Brien, L Wang, M Dichgans, M Kubo, M Serizawa, MA Ikram, MV Holmes, P Jerrard-Dunne, P Kraft, P Polychronopoulos, PC Ng, RL Sacco, RS Epstein, S Bevan, S Gretarsdottir, S Gretarsdottir, S Lanfranconi, S Olsson, S Seshadri, S Seshadri, SE Nissen, The International Warfarin Pharmacogenetics Consortium, VG Manolopoulos, VL Roger   +55 more
core   +2 more sources

Non-greedy Tree-based Learning for Estimating Global Optimal Dynamic Treatment Decision Rules with Continuous Treatment Dosage [PDF]

arXiv, 2023
Dynamic treatment regime (DTR) plays a critical role in precision medicine when assigning patient-specific treatments at multiple stages and optimizing a long term clinical outcome. However, most of existing work about DTRs have been focused on categorical treatment scenarios, instead of continuous treatment options.
arxiv