Results 121 to 130 of about 192,309 (409)
Clinical Pharmacology in Drug Development, EarlyView.Abstract Soticlestat (TAK‐935) is a cholesterol 24‐hydroxylase inhibitor. A physiologically‐based pharmacokinetic model has been developed to predict potential soticlestat drug–drug interactions (DDIs) using the Simcyp v20 Population‐based Simulator and verified with data from single‐/multiple‐rising‐dose and clinical DDI studies.
Hongxia Jia +7 more
wiley +1 more source
Estimate the Warfarin Dose by Ensemble of Machine Learning Algorithms [PDF]
arXiv, 2018 Warfarin dosing remains challenging due to narrow therapeutic index and highly individual variability. Incorrect warfarin dosing is associated with devastating adverse events. Remarkable efforts have been made to develop the machine learning based warfarin dosing algorithms incorporating clinical factors and genetic variants such as polymorphisms in ...
arxiv
Optimally weighted average derivative effects [PDF]
arXiv, 2023 Weighted average derivative effects (WADEs) are nonparametric estimands with uses in economics and causal inference. Debiased WADE estimators typically require learning the conditional mean outcome as well as a Riesz representer (RR) that characterises the requisite debiasing corrections.
arxiv
Thrombosis and Haemostasis, 2016 Summary In addition to warfarin, there are four non-vitamin K antagonist oral anticoagulants (NOACs) available for stroke prevention in non valvular atrial fibrillation (NVAF). There are limited data on the comparative risks of major bleeding among newly
G. Lip +6 more
semanticscholar +1 more source
Coexisting Cardiac and Hematologic Disorders. [PDF]
, 2016 Patients with concomitant cardiac and hematologic disorders presenting for noncardiac surgery are challenging. Anemic patients with cardiac disease should be approached in a methodical fashion.
Goldhammer, Jordan E., Kohl, Benjamin A.
core +3 more sources
Journal of Cardiovascular Electrophysiology, Volume 34, Issue 1, Page 7-13, January 2023., 2023 Abstract Introduction Transesophageal echocardiography (TEE) is recommended to rule out endocarditis in patients with cardiac implantable electronic devices (CIED). A lead‐based echodensity (LBE), however, is often found on TEE in patients with a CIED and may not represent an infection.
Neel J. Patel +4 more
wiley +1 more source
Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.
New England Journal of Medicine, 2005 BACKGROUND The management of warfarin therapy is complicated by a wide variation among patients in drug response. Variants in the gene encoding vitamin K epoxide reductase complex 1 (VKORC1) may affect the response to warfarin.
M. Rieder +9 more
semanticscholar +1 more source
Legal and professional implications of shared care: a case study in oral anticoagulation stroke prevention therapy. [PDF]
, 2015 Policy initiatives and technological advances enable the use of integrated shared care models of healthcare delivery whereby the focus of care is moved from the hospital to the community, and also of models where patients take increasing responsibility ...
Coleman, B +3 more
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Real‐world evidence involving healthcare database studies is well established for making causal inferences in post‐market drug safety studies and methods, data, and research infrastructure for evaluating effectiveness have advanced in recent years. The rapidly expanding field of etiologic research using insurance claims and electronic health records ...
Shirley V. Wang +6 more
wiley +1 more source
Patient Preference and Adherence, 2010 Patrick P Kneeland, Margaret C FangThe University of California, San Francisco Division of Hospital Medicine, San Francisco, CA, USAAbstract: Warfarin therapy reduces morbidity and mortality related to thromboembolism. Yet adherence to long-term warfarin
Patrick P Kneeland, Margaret C Fang
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