Results 111 to 120 of about 102,210 (307)

Advances in Unconventional and Sustainable Synthetic Approaches to Benzopyran Scaffolds

The Chemical Record, EarlyView.
This review provides a comprehensive and critical analysis of low‐impact synthetic methodologies reported in the last 8 years (2018–2026) for the construction of benzopyran‐derived scaffolds, such as coumarins, flavones, chromones, chromenes, and chromanes. The benzopyran scaffold is a versatile family of heterocycles found in a wide range of bioactive
Nathalia B. Sá, Patrick C. Nobre, Isabelly O. Ferreira, Juliano B. Azeredo, Vanessa Nascimento   +4 more
wiley   +1 more source

Association between Cytochrome P450 2 C9 and Vitamin K Epoxide Reductase Complex Subunit 1 Polymorphisms with Warfarin dose among Iranian Patients

Research in Molecular Medicine, 2016
Background: Warfarin is a common anticoagulant drug that has a narrow therapeutic index; higher dose causes excessive bleeding and lower dose leads to cerebrovascular clotting and stroke in patients.
Reyhaneh Kameli, Mandana Hasanzad, Zahra Tahmasebi Fard, Mojgan Babanejad, Mahdieh Imeni, Lotfollah Feizi Barnaji, Atoosa Madadkar, Seyed Hamid Jamaldini   +7 more
doaj  

Effects of formulation types on pharmacodynamics of warfarin in patients with cerebral infarction and dysphagia

, 2019
Young-Ji Kim,1,2 Jong-Woo Jeong,1 Youngshin Song,3 Tae-Sung Koo1 1Graduate School of New Drug Discovey and Development, Chungnam National University, Daejeon 305-764, Republic of Korea; 2Chungnam National University Hospital, Daejeon 305-764, Republic of
Jeong JW, Kim YJ, Koo TS, Song Y
core  

Addressing Long‐Tailed Drug–Drug Interactions Through Minimisation of Predictive Uncertainty and Loss Sharpness

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Drug–Drug Interaction (DDI) prediction is critical for ensuring patient safety, particularly under long‐tailed distributions, where frequent (head) interactions dominate whereas rare (tail) interactions remain underrepresented. Conventional loss functions such as cross‐entropy often tend to overfit head classes while they underperform on rare ...
Chao Liu, Xizhao Wang, Farhad Pourpanah, Sam Kwong   +3 more
wiley   +1 more source

PID and MPC Algorithms for Automatic Warfarin Dosing

reservedAl giorno d’oggi il warfarin è il farmaco anticoagulante più diffuso per il trattamento di pazienti soggetti a rischio tromboembolico. La propensione del sangue a coagulare si misura tramite un parametro, detto INR (International Normalized ...
FENIO, LINDA
core  

Extinction Debt Paid Off: The Demise of the European Polecat (Mustela putorius) in NE Iberia

Integrative Zoology, EarlyView.
We studied a vanishing polecat population for a decade, until its ultimate demise, using camera trap and roadkill data, landscape descriptors and dietary and toxicological analyses.Polecat favoured farmland and avoided forests and water bodies occupied by the invasive American mink.
Salvador Salvador, Roger Puig‐Gironès, Xavier Llopart, Santiago Palazón, Miguel Clavero   +4 more
wiley   +1 more source

Comparison of Temporary Interruption of Warfarin Therapy for 3 and 5 days before Surgery in Thailand: A Randomized Controlled Trial

Siriraj Medical Journal, 2017
Objective: The ACCP guideline 2008 recommended cessation of warfarin five days before surgery. However, based on the observation of the clinical practice at Siriraj Hospital, we suggested a shorter period of three days before surgery.
Angsu Chartrungsan, Pansak Laksanabunsong, Akarin Nimmannit, Bundarika Bundarika Suwanawiboon, Naravat Poungvarin, Wanchai Wongkornrat, Kriangkrai Tantiwongkosri, Worawong Slisatkorn, Pranya Sakiyalak, Punnarerk Thongcharoen, Thaworn Subtaweesin, Somchai Sriyoschati, Teeravit Phanchaipetch   +12 more
doaj  

Whole‐Body CT Utilisation in Adult Trauma: Guideline Compliance, Incidental Findings, and the Role of Anticoagulation in Low‐Energy Falls at a Regional New Zealand Centre

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Introduction Whole‐body CT (WBCT) is central to major trauma assessment, but indiscriminate use carries a substantial radiation burden. The Central Region Trauma Network's Early Radiological Imaging in Major Trauma Guideline (CPG154), adopted at this centre, specifies criteria for WBCT and excludes low‐energy falls from standing height.
Vamsi Thammandra, Jonny Russell
wiley   +1 more source

THE IL-6 DEPENDENT EFFECT OF ORAL WARFARIN IN HEART VALVE REPLACEMENT PATIENTS BY MEASURING INTERACTING CLINICAL AND DEMOGRAPHIC VARIABLES

Pakistan Armed Forces Medical Journal, 2016
Objective: To examine an inflammatory effect of warfarin and comparing with IL-6 levels along with different demographic and clinical variables. Study Design: Qusai experimental study.
Huma Shafiq, Imran Asghar, Amir Rashid, Asifa Majeed, Suhail Razak   +4 more
doaj   +2 more sources

Number needed to treat for net clinical benefit of oral anticoagulants in Asian patients with atrial fibrillation

Journal of Arrhythmia
Background Oral anticoagulants (OAC) can reduce ischemic stroke/systemic embolism (SSE) in patients with non‐valvular atrial fibrillation (AF) while increasing the risk of major bleeding. We aimed to analyze the number needed to treat for the net benefit
Rungroj Krittayaphong, Satchana Pumprueg, Ahthit Yindeengam, Gregory Y. H. Lip   +3 more
doaj   +1 more source