Association Between VKORC1 Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis [PDF]
MedicinaBackground and Objectives: The vitamin K epoxide reductase complex subunit 1 (VKORC1) plays a central role in the vitamin K cycle, which is essential for γ-carboxylation of multiple bone-related proteins.
Ştefan Cristian Vesa +9 more
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Predictor Role of VKORC1 rs9923231, CYP4F2 rs2108622, and GGCX rs11676382 Polymorphisms of 5 Years Mortality of Patients with Acute Ischemic Stroke [PDF]
MedicinaBackground and Objectives: The aim of this study was to evaluate the potential predictive value of VKORC1, CYP4F2, and GGCX polymorphisms, as well as other clinical and demographic factors, for 5-year mortality in patients with acute ischemic stroke (AIS)
Silvina Iluţ +11 more
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The impact of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin dose requirement in Saudi patients [PDF]
Frontiers in PharmacologyBackgroundLimited data are available on factors that affect warfarin dose requirement in Saudi patients. Saudis are among the underrepresented ethnic groups in warfarin pharmacogenetics research.
Salha Jokhab +5 more
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INVESTIGATING THE GENETIC EFFECT OF VKORC1 GENE POLYMORPHISM ON WARFARIN RESPONSE IN EGYPTIAN HEART PATIENTS [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2023 Warfarin is a common oral anticoagulant, but the dose needed for each patient can vary by as much as 20 times due to both environmental and genetic factors.
Hassan Donkol +4 more
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The VKORC1 and CYP2C9 gene variants as pharmacogenetic factors in acenocoumarol therapy in Serbian patients - consideration of hypersensitivity and resistance [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2022 Introduction/Objective. Coumarin therapy represents one of the best models for applying pharmacogenetics. The contribution of factors influencing coumarin therapy can vary significantly between ethnic groups, which justifies conducting population ...
Rakićević Ljiljana +3 more
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Lack of Association of Clinical Factors (SAMe-TTR) with / Genotype and Anticoagulation Control Quality [PDF]
Journal of Stroke, 2015 Background and PurposeAdvantages of new oral anticoagulations may be greater in atrial fibrillation (AF) patients of poor anticoagulation control with warfarin.
Yun Kyung Park +6 more
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Poultry Science, 2023 : Sodium dehydroacetate (S-DHA) is used widely as a preservative in several products, including poultry feed. The anticoagulation effect of 200 mg/kg S-DHA in rats has been reported to accompany a reduction in hepatic expression of vitamin K epoxide ...
Jinge Xu +6 more
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بررسی فارماکوژنتیک وارفارین با ژنوتیپ پلی‌مورفیسم ژن‌های CYP2C9 و VKORC1 و تعیین حساسیت و مقاومت به وارفارین در جمعیت جنوب ایران [PDF]
مجله دانشکده پزشکی اصفهان, 2023 مقاله پژوهشیمقدمه: از سال ۱۹۵۰، وارفارین به‌عنوان ضد انعقاد برای درمان و پیشگیری از شرایط ترومبوآمبولی استفاده می‌شود. عوامل مختلفی همچون سن، وزن، رژیم غذایی و عوامل ژنتیکی مثل ژن CYP2C9وVKORC1 در تعیین دوز وارفارین مؤثر هستند.
جواد جهانگیری +2 more
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Novel associations of VKORC1 variants with higher acenocoumarol requirements. [PDF]
PLoS ONE, 2013 Algorithms combining both clinical and genetic data have been developed to improve oral anticoagulant therapy. Three polymorphisms in two genes, VKORC1 and CYP2C9, are the main coumarin dose determinants and no additional polymorphisms of any relevant ...
Ana Isabel Anton +7 more
doaj +1 more source
Blood Advances, 2018 : Vitamin K reduction is catalyzed by 2 enzymes in vitro: the vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) and its isozyme VKORC1-like1 (VKORC1L1). In vivo, VKORC1 reduces vitamin K to sustain γ-carboxylation of vitamin K-dependent proteins,
Katrin J. Czogalla +6 more
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