Association Between VKORC1 Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis [PDF]
MedicinaBackground and Objectives: The vitamin K epoxide reductase complex subunit 1 (VKORC1) plays a central role in the vitamin K cycle, which is essential for γ-carboxylation of multiple bone-related proteins.
Ştefan Cristian Vesa +9 more
doaj +2 more sources
VKORC1: molecular target of coumarins [PDF]
Journal of Thrombosis and Haemostasis, 2007 The genetic diagnosis of a single family with combined vitamin K-dependent clotting factor deficiency (VKCFD2, OMIM #607473) finally led to the identification and molecular characterization of vitamin K epoxide reductase (VKORC1). VKORC1 is the key enzyme of the vitamin K cycle and the molecular target of coumarins, which represent the most commonly ...
J, Oldenburg +3 more
exaly +3 more sources
GGCX and VKORC1 inhibit osteocalcin endocrine functions [PDF]
Journal of Cell Biology, 2015 Osteocalcin (OCN) is an osteoblast-derived hormone favoring glucose homeostasis, energy expenditure, male fertility, brain development, and cognition. Before being secreted by osteoblasts in the bone extracellular matrix, OCN is γ-carboxylated by the γ-carboxylase (GGCX) on three glutamic acid residues, a cellular process requiring reduction of vitamin
Mathieu Ferron +2 more
exaly +3 more sources
The impact of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin dose requirement in Saudi patients [PDF]
Frontiers in PharmacologyBackgroundLimited data are available on factors that affect warfarin dose requirement in Saudi patients. Saudis are among the underrepresented ethnic groups in warfarin pharmacogenetics research.
Salha Jokhab +5 more
doaj +2 more sources
Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin [PDF]
Genetics in Medicine, 2008 American College of Medical Genetics statements and guidelines are designed primarily as an educational resource for medical geneticists and other health care professionals to help them provide quality medical genetic services. Adherence to these standards and guidelines does not necessarily ensure a successful medical outcome.
Elaine Lyon +2 more
exaly +3 more sources
Predictor Role of VKORC1 rs9923231, CYP4F2 rs2108622, and GGCX rs11676382 Polymorphisms of 5 Years Mortality of Patients with Acute Ischemic Stroke [PDF]
MedicinaBackground and Objectives: The aim of this study was to evaluate the potential predictive value of VKORC1, CYP4F2, and GGCX polymorphisms, as well as other clinical and demographic factors, for 5-year mortality in patients with acute ischemic stroke (AIS)
Silvina Iluţ +11 more
doaj +2 more sources
Novel associations of VKORC1 variants with higher acenocoumarol requirements. [PDF]
PLoS ONE, 2013 Algorithms combining both clinical and genetic data have been developed to improve oral anticoagulant therapy. Three polymorphisms in two genes, VKORC1 and CYP2C9, are the main coumarin dose determinants and no additional polymorphisms of any relevant ...
Ana Isabel Anton +7 more
doaj +4 more sources
Common VKORC1 and GGCX polymorphisms associated with warfarin dose [PDF]
Pharmacogenomics Journal, 2005 We report a novel combination of factors that explains almost 60% of variable response to warfarin. Warfarin is a widely used anticoagulant, which acts through interference with vitamin K epoxide reductase that is encoded by VKORC1. In the next step of the vitamin K cycle, gamma-glutamyl carboxylase encoded by GGCX uses reduced vitamin K to activate ...
Panos Deloukas +2 more
exaly +3 more sources
INVESTIGATING THE GENETIC EFFECT OF VKORC1 GENE POLYMORPHISM ON WARFARIN RESPONSE IN EGYPTIAN HEART PATIENTS [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2023 Warfarin is a common oral anticoagulant, but the dose needed for each patient can vary by as much as 20 times due to both environmental and genetic factors.
Hassan Donkol +4 more
doaj +1 more source
Variation in VKORC1 Is Associated with Vascular Dementia [PDF]
Journal of Alzheimer’s Disease, 2020 Background: The genetic variant rs9923231 ( VKORC1) is associated with differences in the coagulation of blood and consequentially with sensitivity to the drug warfarin. Variation in VKORC1 has been linked in a gene-based test to dementia/Alzheimer’s disease in the parents of participants,
Jure Mur +7 more
openaire +5 more sources