Results 11 to 20 of about 3,566 (133)

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin. [PDF]

Clin Pharmacol Ther
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Shaul C, Mujahed W, Idries I, Wanounou M, Bialer M, Caraco Y.   +5 more
europepmc   +2 more sources

Distribution and frequency of Vkorc1 polymorphisms in house mice and Norway rats in the northeastern United States. [PDF]

Pest Manag Sci
This study assesses the distribution and frequency of Vkorc1 polymorphisms in house mice and Norway rats in northeastern USA. House mice showed higher frequency of Vkorc1 mutations than Norway rats. The A32V and Y139F mutations are first reported in mice, and the L128V is newly reported in Norway rats.
Yu JJ, Toledo A, Kasprowicz AE, Phifer-Rixey MV, Pan X, Daramola B, Wang C.   +6 more
europepmc   +2 more sources

Challenging Anticoagulation With Warfarin and Heparin Following Mechanical Mitral Valve Replacement in a Patient With Infective Endocarditis: A Case Report Highlighting Diagnostic Difficulties. [PDF]

Clin Case Rep
ABSTRACT Warfarin remains the cornerstone of anticoagulation therapy following mechanical heart valve replacement. However, challenging anticoagulation responses, resistance to warfarin, and even more rarely to both warfarin and heparin pose significant clinical challenges and complicate management strategies.
Khan M, Ahmad A, Khan M, Zainullah FNU, Khan N, Nazir F, Ahmed W, Ullah N, Anees M, Kamil KA.   +9 more
europepmc   +2 more sources

Genetic Warfarin-Resistance Resulting in Surgery to Change a Prosthetic Valve

European Journal of Case Reports in Internal Medicine, 2020
Warfarin is a readily available anticoagulant used worldwide in a variety of clinical scenarios. Patients who need more than 15 mg/day are considered to be warfarin resistant.
Jahanzeb Malik, Uzma Ishaq, Nismat Javed, Mirza Adnan Baig, Muhammad Javaid   +4 more
doaj   +1 more source

Effects of CYP2C9 and VKORC1 polymorphisms on warfarin sensitivity and responsiveness during the stabilization phase of therapy

Saudi Pharmaceutical Journal, 2019
The main objective of this study is to assess the effects of CYP2C9 and VKORC1 polymorphisms on warfarin sensitivity and responsiveness in a Jordanian population during the stabilization phase of treatment.
Laith N. AL-Eitan, Ayah Y. Almasri, Rame H. Khasawneh   +2 more
doaj   +1 more source

Analysis of vkorc1 polymorphisms in Norway rats using the roof rat as outgroup

BMC Genetics, 2010
Background Certain mutations in the vitamin K epoxide reductase subcomponent 1 gene (vkorc1) mediate rodent resistance to warfarin and other anticoagulants. Testing for resistance often involves analysis of the vkorc1.
Borchert Jeff N, Moore Anthony, Song Ying, Díaz Juan C, Kohn Michael H   +4 more
doaj   +1 more source

A cardiovascular phenotype in warfarin-resistant Vkorc1 mutant rats☆

Artery Research, 2008
Background: The inhibition of the vitamin K cycle by warfarin promotes arterial calcification in the rat. Conceivably, genetically determined vitamin K deficiency owing to a mutant epoxide reductase subcomponent 1 (Vkorc1) gene, a key component of the ...
Michael H. Kohn, Roger E. Price, Hans-Joachim Pelz   +2 more
doaj   +1 more source

The efficacy of low-dose warfarin initiation (3 mg versus 5 mg) in newly diagnosed venous thromboembolism patients among a population with a high prevalence of warfarin-sensitive haplotype of the VKORC1 gene: a randomized controlled trial

Hematology, 2022
Objectives The fact that a lower warfarin maintenance dose is required by Asian populations is well-known. Currently, the American College of Chest Physicians recommends commencing warfarin at a dose between 5 and 10 mg for venous thromboembolism (VTE ...
Bundarika Suwanawiboon, Wannaphorn Rotchanapanya, Komkrit Mahaprom, Wanna Thongnoppakhun, Yupaporn Lalerd, Chanin Limwongse, Nuttawut Sermsathanasawadi, Weerapat Owattanapanich   +7 more
doaj   +1 more source

VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey.

PLoS ONE, 2010
Osteoporosis, defined by low bone mineral density (BMD), is common among postmenopausal women. The distribution of BMD varies across populations and is shaped by both environmental and genetic factors.
Dana C Crawford, Kristin Brown-Gentry, Mark J Rieder   +2 more
doaj   +1 more source

The Effect of CYP2C9 and VKORC1 Genetic Polymorphism on Warfarin Dose Requirements in a Sample of Iraqi Patients [PDF]

Journal of Kerman University of Medical Sciences, 2021
Background: Warfarin is the most widely used oral anticoagulant for the prevention and treatment of thromboembolic disorders. Because of narrow therapeutic index and various genetic and non-genetic factors that influence the disposition of the drug, its ...
Maha Ali Saleh, Haitham Mahmood Kadhim, Ahmed Sahib, Ahmed S Abdulamir, Rafed Altawil   +4 more
doaj   +1 more source