Results 11 to 20 of about 3,496 (176)

Challenging Anticoagulation With Warfarin and Heparin Following Mechanical Mitral Valve Replacement in a Patient With Infective Endocarditis: A Case Report Highlighting Diagnostic Difficulties. [PDF]

Clin Case Rep
ABSTRACT Warfarin remains the cornerstone of anticoagulation therapy following mechanical heart valve replacement. However, challenging anticoagulation responses, resistance to warfarin, and even more rarely to both warfarin and heparin pose significant clinical challenges and complicate management strategies.
Khan M, Ahmad A, Khan M, Zainullah FNU, Khan N, Nazir F, Ahmed W, Ullah N, Anees M, Kamil KA.   +9 more
europepmc   +2 more sources

Systematic Druggable Genome-Wide Analysis Identifies Therapeutic Targets for Aging: A Mendelian Randomization Study. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Currently, there are no effective drug treatments for aging. Mendelian randomization (MR) has been widely applied to repurpose existing drugs and identify new therapeutic targets. Our aim is to identify aging‐related therapeutic targets and evaluate their potential adverse effects, underlying mechanisms, and actionable ...
Zhang Y, Wang M, Li H, Jin T, Peng S, Dong Y, Deng C, Li H, Li X, Qin J, Ye X.   +10 more
europepmc   +2 more sources

The VKORC1 and CYP2C9 gene variants as pharmacogenetic factors in acenocoumarol therapy in Serbian patients - consideration of hypersensitivity and resistance [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2022
Introduction/Objective. Coumarin therapy represents one of the best models for applying pharmacogenetics. The contribution of factors influencing coumarin therapy can vary significantly between ethnic groups, which justifies conducting population ...
Rakićević Ljiljana, Kovač Mirjana, Radojković Dragica, Radojković Milica   +3 more
doaj   +1 more source

VKORC1 Pharmacogenomics Summary [PDF]

Pharmacogenetics and Genomics, 2010
The VKORC1 gene encodes the VKORC1 (vitamin K epoxide reductase) protein, which is a key enzyme in the vitamin K cycle [1,2]. VKORC1 is a 163 amino acid integral membrane protein associated with the endoplasmic reticulum and VKORC1 mRNA is broadly expressed in many different tissues [3].
Ryan P, Owen, Li, Gong, Hersh, Sagreiya, Teri E, Klein, Russ B, Altman   +4 more
openaire   +2 more sources

Lack of Association of Clinical Factors (SAMe-TTR) with / Genotype and Anticoagulation Control Quality [PDF]

Journal of Stroke, 2015
Background and PurposeAdvantages of new oral anticoagulations may be greater in atrial fibrillation (AF) patients of poor anticoagulation control with warfarin.
Yun Kyung Park, Mi ji Lee, Jae Ha Kim, Suk Jae Kim, June Soo Kim, Soo-Youn Lee, Oh Young Bang   +6 more
doaj   +1 more source

VKORC1 single nucleotide polymorphisms in rodents in Spain

Chemosphere, 2022
Rodents are considered one of the animal pests with the greatest impact on agricultural production and public health. Anticoagulant rodenticides (ARs), used as one of the most effective ways to control rodent populations worldwide, inhibit the vitamin K 2,3-epoxide reductase (VKORC1) enzyme involved in blood coagulation.
Azucena Bermejo-Nogales, José A. Rodríguez Martín, Julio Coll, José M. Navas   +3 more
openaire   +3 more sources

Sodium dehydroacetate-induced disorder of coagulation function in broiler chickens and the protective effect afforded by vitamin K

Poultry Science, 2023
: Sodium dehydroacetate (S-DHA) is used widely as a preservative in several products, including poultry feed. The anticoagulation effect of 200 mg/kg S-DHA in rats has been reported to accompany a reduction in hepatic expression of vitamin K epoxide ...
Jinge Xu, Fuxing Hao, Cunkai Wang, Zeting Zhao, Meng Zhang, Xin Chen, Yumei Zhang   +6 more
doaj   +1 more source

Improving Genotype Imputation in High-Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches. [PDF]

Clin Pharmacol Ther
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Asiimwe IG, You T, Carr DF, Pirmohamed M, Davies G, Jorgensen AL, UNITE4TB Consortium.   +6 more
europepmc   +2 more sources

بررسی فارماکوژنتیک وارفارین با ژنوتیپ پلی‌مورفیسم ژن‌های CYP2C9 و VKORC1 و تعیین حساسیت و مقاومت به وارفارین در جمعیت جنوب ایران [PDF]

مجله دانشکده پزشکی اصفهان, 2023
مقاله پژوهشیمقدمه: از سال ۱۹۵۰، وارفارین به‌عنوان ضد انعقاد برای درمان و پیشگیری از شرایط ترومبوآمبولی استفاده می‌شود. عوامل مختلفی همچون سن، وزن، رژیم غذایی و عوامل ژنتیکی مثل ژن  CYP2C9وVKORC1 در تعیین دوز وارفارین مؤثر هستند.
جواد جهانگیری, بابک شیرازی یگانه, اردشیر بهمنی   +2 more
doaj   +1 more source

Genetic Warfarin-Resistance Resulting in Surgery to Change a Prosthetic Valve

European Journal of Case Reports in Internal Medicine, 2020
Warfarin is a readily available anticoagulant used worldwide in a variety of clinical scenarios. Patients who need more than 15 mg/day are considered to be warfarin resistant.
Jahanzeb Malik, Uzma Ishaq, Nismat Javed, Mirza Adnan Baig, Muhammad Javaid   +4 more
doaj   +1 more source