Results 41 to 50 of about 3,566 (133)

Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study

Clinics, 2019
OBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with ...
Merih Ozgen, Didem Turgut Cosan, Fulya Doganer, Ahu Soyocak, Onur Armagan, Selen Kuzgun, Ayse Merve Aydogan, Hasan Veysi Gunes, Irfan Degirmenci, Fezan Mutlu   +9 more
doaj   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, Volume 13, Issue 53, 24 September 2026.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Polymorphisms of genes CYP2C9 and VKORC1 in patients with venous thromboembolic complications in Moscow population: effects on stability of anticoagulant therapy and frequency of hemorrhage

Терапевтический архив, 2011
Aim. To investigate frequency of carriage of genetic polymorphisms CYP2C9 and VKORC1 in patients with venous thromboembolic complications (VTEC) in Moscow population given warfarin treatment and effects of this carriage on stability of anticoagulation ...
Natal'ya Mikhaylovna Vorob'eva, Elizaveta Pavlovna Panchenko, Anatoliy Borisovich Dobrovol'skiy, Elena Vladimirovna Titaeva, Zukhra Bilyalovna Khasaeva, Nina Valer'evna Konovalova, Anton Yuvenal'evich Postnov, Aleksandr Ivanovich Kirienko, N M Vorobyeva, E P Panchenko, A B Dobrovolsky, E V Titaeva, Z B Khasaeva, N V Konovalova, A Yu Postnov, A I Kirienko   +15 more
doaj  

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 510-519, August 2026.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction

Thrombosis Journal, 2008
Background Warfarin treatment has a narrow therapeutic range, requiring meticulous monitoring and dosage titration. Individual dosage requirement has recently partly been explained by genetic variation of the warfarin metabolizing enzyme CYP2C9 and the ...
Seljeflot Ingebjørg, Kierulf Peter, Johansen Per, Sjaatil Stine T, Narum Sigrid, Kringen Marianne K, Sharikabad Mohammad N, Haug Kari, Arnesen Harald, Brørs Odd   +9 more
doaj   +1 more source

Next‐Generation Surgery: Integrating Artificial Intelligence, Genetic Technologies, Bioengineering and Rehabilitation Into Modern Practices

Exploration, Volume 6, Issue 3, June 2026.
This graphic abstract depicts the convergence of artificial intelligence, genetic technologies, bioengineering, and rehabilitation as the core pillars of next‐generation surgery. These domains collectively enhance preoperative planning, intraoperative precision, tissue reconstruction, and postoperative recovery, driving a paradigm shift toward ...
Dengxiong Li, Jie Wang, Zhipeng Wang, Ruicheng Wu, Zhouting Tuo, Fanglin Shao, Wenjing Ge, Ziyu Shu, Yubo Yang, Dilinaer Wusiman, Qingxin Yu, Luxia Ye, Alisha Pati‐Alam, Facai Zhang, Koo Han Yoo, Susan Heavey, William C. Cho, Dechao Feng   +17 more
wiley   +1 more source

Risk of hemorrhagic stroke in warfarin‐treated patients following heart valve replacement: Findings from the MAGPIE study

Ibrain, Volume 12, Issue 2, Page 250-258, Summer 2026.
Among 568 mechanical heart valve replacement patients in Bangladesh, hemorrhagic stroke occurred in 4.4% with 52% mortality. Severe pulmonary hypertension increased risk 4.4‐fold, and warfarin therapy ≥104 months nearly doubled the risk, highlighting the need for long‐term risk monitoring in anticoagulated valve patients.
Dipannita Adhikary, Md. Abdullah Yusuf, AM Nayeem Parvez, Sheikh M. B. Faruque, Santo Barman, Adneen Moureen, Luke J. Rogers, Aziz Momin, Venkatachalam Chandrasekaran, Asit B. Adhikary, Redoy Ranjan   +10 more
wiley   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Field trials to assess resistance to warfarin and difenacoum of house mice in relation to the occurrence of variants in the vkorc1-gene before and after the treatments

Julius-Kühn-Archiv, 2011
House mice (Mus musculus domesticus) vary considerably in their susceptibility to anticoagulants, and several non-synonymous sequence variants in the coding region of the vitamin K epoxide reductase subcomponent 1 gene (vkorc1) were found in Germany ...
Endepols, S., Klemann, N., Song, Y., Kohn, M. H.   +3 more
doaj   +1 more source

Single‐Cell Transcriptome‐Wide Mendelian Randomization and Colocalization Uncover Potential Immunocytes‐Related Therapeutic Targets for Obesity

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Weight‐loss treatment is crucial for individuals with obesity to prevent various complications. The role of Immune cells in obesity has been recently recognized, whereas its translation into therapy requires identifying key target genes. We performed Mendelian randomization (MR) analysis to assess causal relationships between expression ...
Xingjian Zhang, Yong Tian, Xiaoying Ren, Juan Tian, Jia Liu, Guang Wang   +5 more
wiley   +1 more source