The Effect of Rivaroxaban on CYP4F2 and Transcription Factors’ Activity in HUVECs
Applied Sciences (Switzerland), 2021 Interindividual variabilities between patients taking the anticoagulant rivaroxaban are a result of hepatic metabolism by CYP 450 enzymes. The objective of this study was to evaluate the impact of rivaroxaban on CYP4F2 and transcription factors’ activity
Vaiva Lesauskaite +2 more
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The impact of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin dose requirement in Saudi patients [PDF]
Frontiers in PharmacologyBackgroundLimited data are available on factors that affect warfarin dose requirement in Saudi patients. Saudis are among the underrepresented ethnic groups in warfarin pharmacogenetics research.
Salha Jokhab +5 more
doaj +2 more sources
Exploratory plasma ctDNA genomic biomarkers identified by whole-exome sequencing and a novel bioinformatics pipeline in advanced driver-negative NSCLC [PDF]
Scientific ReportsImmune checkpoint inhibitors (ICIs) have improved outcomes in advanced non-small-cell lung cancer (NSCLC), but predictive biomarkers remain suboptimal. Blood-based tumour mutational burden (bTMB) captures part of the signal, yet its clinical performance ...
Luis Posado-Domínguez +14 more
doaj +2 more sources
Simvastatin inhibits 20-Hydroxyeicosatetraenoic acid formation: docking and in vitro assay [PDF]
BMC Pharmacology and ToxicologyIntroduction 20-Hydroxyeicosatetraenoic acid (20-HETE), a metabolite of arachidonic acid catalyzed mainly by cytochrome P450 (CYP) enzymes CYP4A11 and CYP4F2, plays a role in cardiovascular homeostasis.
Yazun Jarrar +6 more
doaj +2 more sources
The curious family of cytochrome P450 4F fatty acid ω-hydroxylases: recent developments in their function and relevance for human health [PDF]
Open BiologyCytochrome P450 enzymes (CYP, P450) are indispensable for human health and catalyse a plethora of reactions contributing to the clearance of xenobiotics, steroid and bile acid biosynthesis, and the functionalization of vitamins in the human body.
Brisa Caroline Alves Chagas +3 more
doaj +2 more sources
Predictor Role of VKORC1 rs9923231, CYP4F2 rs2108622, and GGCX rs11676382 Polymorphisms of 5 Years Mortality of Patients with Acute Ischemic Stroke [PDF]
MedicinaBackground and Objectives: The aim of this study was to evaluate the potential predictive value of VKORC1, CYP4F2, and GGCX polymorphisms, as well as other clinical and demographic factors, for 5-year mortality in patients with acute ischemic stroke (AIS)
Silvina Iluţ +11 more
doaj +2 more sources
Integrated analysis identifies key genes underlying the bidirectional association between depression and renal failure [PDF]
Scientific ReportsDepression is a common psychiatric comorbidity in individuals with end-stage renal disease (ESRD). However, the underlying biological mechanisms and the precise relationship between depression and renal failure remain unclear. While interventions such as
Zhengqi Qiu +5 more
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Application of rapid genotyping of Warfarin individualized pharmacogenetic variants in Warfarin therapy [PDF]
Scientific ReportsWarfarin is the most widely used oral anticoagulant in clinical practice. The cytochrome P450 2C9 (CYP2C9), vitamin K epoxide reductase complex 1 (VKORC1), and cytochrome P450 4F2 (CYP4F2) genotypes are associated with warfarin dose requirements in China.
Defa Huang +10 more
doaj +2 more sources
Pharmacodynamic Modeling of Warfarin Dosing Algorithm for Cardiovascular Patients in Indonesia: A Tailored Method to Anticoagulation Therapy [PDF]
Drug Design, Development and TherapyNorisca Aliza Putriana,1 Irma Rahayu Latarissa,2 Taofik Rusdiana,1 Tina Rostinawati,3 Mohammad Rizki Akbar4 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia; 2Department of ...
Putriana NA +4 more
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BMC Molecular and Cell Biology, 2023 Background Cytochrome P450 4F2 (CYP4F2) enzyme is a member of the CYP4 family responsible for the metabolism of fatty acids, therapeutic drugs, and signaling molecules such as arachidonic acid, tocopherols, and vitamin K.
Mahvash Farajzadeh-Dehkordi +3 more
doaj +1 more source