Results 31 to 40 of about 2,623 (125)

Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice

Kidney & Blood Pressure Research, 2021
Introduction: 20-Hydroxyeicosatetraenoic acid (20-HETE) is the metabolite of cytochrome P450, which modulates blood pressure by inhibiting renal sodium transport.
Jingjing Wu, Guangrui Lai, Fangjie Chen, Bijun Zhang, Yanyan Zhao   +4 more
doaj   +1 more source

FREQUENCIES OF POLYMORPHISMS IN THE CYTOCHROME’S P450 GENES OF WARFARIN TRANSFORMATION IN A EUROPEAN POPULATION OF EASTERN SIBERIA

Acta Biomedica Scientifica, 2018
Background. Genotypes of the cytochrome p450 isoform (CYP2C9 and CYP4F2) determine warfarin dose requirements. Frequencies of risk alleles and genotypes of CYP2C9 and CYP4F2 gene vary in different races and ethnic groups.Aim.
T. A. Bairova, E. A. Novikova, F. I. Belyalov, E. A. Shchedreeva, K. D. Ievleva, O. V. Kalyuzhnaya, O. A. Ershova, V. G. Pustozerov, O. A. Kovaleva, I. V. Rasputina, I. A. Noskova, T. V. Batogova, O. V. Kuznetsova, O. Yu. Bogoslova, S. I. Kolesnikov   +14 more
doaj   +1 more source

Impact of VKORC1, CYP4F2 and NQO1 gene variants on warfarin dose requirement in Han Chinese patients with catheter ablation for atrial fibrillation

BMC Cardiovascular Disorders, 2018
Background The anticoagulation of atrial fibrillation catheter ablation during the perioperative stage does matter and should be treated with discretion. We aimed to assess impact of three important genes participating in vitamin K cycle (i.e.
Jiao Li, Wenlong Yang, Zhonghui Xie, Kun Yu, Yuhua Chen, Kaijun Cui   +5 more
doaj   +1 more source

GENETICS OF CLOPIDOGREL RESISTANCE: RECENT DATA

Российский кардиологический журнал, 2015
Antiplatelet therapy is one of the most importance in therapy of patients with injured coronary, cerebral and peripheral arteries. The standard of acute coronary syndrome patients treatment is double antiplatelet therapy: acetylsalicylic acid with ...
K. B. Mirzaev, D. A. Sychev, D. A. Andreev   +2 more
doaj   +1 more source

Pharmacogenetic Warfarin Dosing Algorithm in the Russian Population

Acta Biomedica Scientifica, 2019
Background. To date, there are many pharmacogenetic algorithms for selecting the dose of warfarin. However, there is very little information about the predictive accuracy of the algorithms.
T. A. Bairova, A. Yu. Sambyalova, L. V. Rychkova, E. A. Novikova, F. I. Belyalov, D. S. Sargaeva, E. A. Shchedreeva, T. G. Ignatyeva, O. A. Ershova, V. G. Pustozerov, O. A. Kovaleva, I. V. Rasputina, I. A. Noskova, T. V. Batogova, O. V. Kuznetsova, O. Yu. Bogoslova, S. I. Kolesnikov   +16 more
doaj   +1 more source

Increased α‐tocopherol metabolism in horses with equine neuroaxonal dystrophy

Journal of Veterinary Internal Medicine, 2021
Background Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is an inherited neurodegenerative disorder associated with a vitamin E deficiency within the first year of life.
Erin N. Hales, Hadi Habib, Gianna Favro, Scott Katzman, R. Russell Sakai, Sabin Marquardt, Matthew H. Bordbari, Brittni Ming‐Whitfield, Janel Peterson, Anna R. Dahlgren, Victor Rivas, Carolina Alanis Ramirez, Sichong Peng, Callum G. Donnelly, Bobbi‐Sue Dizmang, Angelica Kallenberg, Robert Grahn, Andrew D. Miller, Kevin Woolard, Benjamin Moeller, Birgit Puschner, Carrie J. Finno   +21 more
doaj   +1 more source

Dispensing of actionable pharmacogenetic drugs among adults receiving cardiovascular disease medications in the Northern Netherlands: A serial cross‐sectional study

Clinical Pharmacology &Therapeutics, EarlyView.
The extent of pharmacogenetic (PGx) drug dispensing among Dutch adults receiving medications for cardiovascular disease (CVD) is unknown. Using the University of Groningen IADB.nl pharmacy database, we performed a serial cross‐sectional study (2019–2023) to estimate the annual prevalence of PGx drug dispensing and annual rates of initiation.
Zhuolin Zhang, Guiling Zhou, Jens H. J. Bos, Eelko Hak, Talitha Feenstra, Frank Klont   +5 more
wiley   +1 more source

Patients with Chronic Inflammatory Diseases Can Experience Higher Exposure of Small Molecule Drugs than Healthy Volunteers: An Analysis of Recently Approved Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Chronic inflammation has long been known to downregulate the activity of certain cytochrome P450 (CYP) enzymes—the main enzymes responsible for the phase I metabolism of many small molecule drugs—potentially leading to higher exposures in patients with chronic inflammatory diseases compared to healthy volunteers. Neglecting this potential difference in
Johannes Tillil, Sathej Gopalakrishnan, Jennifer Dong, Karthik Venkatakrishnan, Charlotte Kloft, Wilhelm Huisinga, Lena Klopp‐Schulze   +6 more
wiley   +1 more source

Pharmacogenetics of warfarin: A literature review [PDF]

КардиоСоматика
Warfarin is an oral indirect anticoagulant that is widely used for the prevention of thromboembolic events. Pharmacogenetic testing is the most promising approach to personalizing warfarin treatment. In this review, we aimed to summarize how the patients’
Nadezhda V. Izmozherova, Muraz A. Shambatov, Artem A. Popov, Daria E. Zhuk, Viktoria A. Solodchenko   +4 more
doaj   +1 more source

EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect

Cancer Science, EarlyView.
Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu, Jingjia Chang, Zhiyong Li, Jin Wu, Pengfei Yu, Jingjing Zheng, Li Li, Jia Tao, Hao Wu, Yintao Li, Ming Liu   +10 more
wiley   +1 more source