Results 21 to 30 of about 2,623 (125)

Pharmacogenomic Calling From Whole-Exome Sequencing in the Taiwanese Population-A Real-World Experience. [PDF]

Mol Genet Genomic Med
This study evaluated pharmacogenomic (PGx) calling from whole‐exome sequencing (WES) in 3562 Taiwanese individuals. Fourteen pharmacogenes were reliably identified, with each person carrying an average of ~2.4 actionable phenotypes. The high actionable frequencies of G6PD deficiency and HLA‐B*58:01 highlight ethnic differences and support WES as a ...
Lin HH, Tsai MM, Chen HA, Hsu RH, Lin YS, Lin YL, Hsu C, Chien YH, Hwu WL, Lee NC.   +9 more
europepmc   +2 more sources

Pleiotropic Effects of Ticagrelor: Influence on CYP4F2 Gene and Protein Expression in HUVEC and HepG2, and Escherichia coli Bacterial Survival

Drug Design, Development and Therapy, 2022
Ugne Meskauskaite,1 Silvija Andruskeviciute,1 Ieva Ciapiene,1 Agne Giedraitiene,2 Vaiva Lesauskaite,1 Vacis Tatarunas1 1Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania; 2Institute of Microbiology and Virology ...
Meskauskaite U, Andruskeviciute S, Ciapiene I, Giedraitiene A, Lesauskaite V, Tatarunas V   +5 more
doaj  

Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke

BMC Medical Genetics, 2019
Background Ischemic stroke (IS) is a serious cardiovascular disease and is associated with several single nucleotide polymorphisms (SNPs). However, the role of Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) gene in IS remains unknown.
Yuan Wu, Junjie Zhao, Yonglin Zhao, Tingqin Huang, Xudong Ma, Honggang Pang, Ming Zhang   +6 more
doaj   +1 more source

Frequencies of polymorphisms in genes affecting the pharmacokinetics of warfarin in the Zaporizhzhia region

Zaporožskij Medicinskij Žurnal, 2021
The aim of the study: to establish the frequencies of polymorphisms in VKORC1, CYP2C9 and CYP4F2 genes among residents of the Zaporizhzhia region. Materials and methods. A total of 150 persons (62 male, 88 female) with a median age of 46 years (26; 58)
M. Yu. Kolesnik, Yа. М. Mykhailovskyi
doaj   +1 more source

NFLUENCE OF CYP4F2*3 ON RESPONSE TO CLOPIDOGREL IN PATIENTS WITH ACUTE CORONARY SYNDROME

Рациональная фармакотерапия в кардиологии, 2018
Background. Carriership of CYP4F2*3 (rs2108622, Val433Met) allelic variant can affect antiplatelet effect of clopidogrel, thus changing efficacy and safety of its standard dose.Aim.
K. B. Mirzaev, O. D. Konova, E. A. Grishina, K. A. Ryzhikova, Zh. A. Sozaeva, D. A. Andreev, M. Y. Gilyarov, D. A. Sychev   +7 more
doaj   +1 more source

Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response

Frontiers in Pharmacology, 2017
Genetic polymorphisms in the gene encoding cytochrome P450 (CYP) 4F2, a vitamin K oxidase, affect stable warfarin dose requirements and time to therapeutic INR.
J. E. Zhang, Kathrin Klein, Kathrin Klein, Andrea L. Jorgensen, Ben Francis, Ana Alfirevic, Stephane Bourgeois, Panagiotis Deloukas, Panagiotis Deloukas, Panagiotis Deloukas, Ulrich M. Zanger, Ulrich M. Zanger, Munir Pirmohamed   +12 more
doaj   +1 more source

Computational Insight Into Vitamin K1 ω-Hydroxylation by Cytochrome P450 4F2

Frontiers in Pharmacology, 2018
Vitamin K1 (VK1) plays an important role in the modulation of bleeding disorders. It has been reported that ω-hydroxylation on the VK1 aliphatic chain is catalyzed by cytochrome P450 4F2 (CYP4F2), an enzyme responsible for the metabolism of eicosanoids ...
Junhao Li, Junhao Li, Hongxiao Zhang, Guixia Liu, Yun Tang, Yaoquan Tu, Weihua Li   +6 more
doaj   +1 more source

Multi‐site Investigation of Genetic Determinants of Warfarin Dose Variability in Latinos

Clinical and Translational Science, 2021
We conducted a multi‐site investigation of genetic determinants of warfarin dose variability in Latinos from the U.S. and Brazil. Patients from four institutions in the United States (n = 411) and Brazil (n = 663) were genotyped for VKORC1 c.‐1639G> A ...
Nihal El Rouby, Leiliane Rodrigues Marcatto, Karla Claudio, Letícia Camargo Tavares, Heidi Steiner, Marianna R. Botton, Steve A. Lubitz, Echo N. Fallon, Kevin Yee, Justin Kaye, Stuart A. Scott, Jason Karnes, Paulo Caleb Junior de Lima Santos, Jorge Duconge, Larisa H. Cavallari   +14 more
doaj   +1 more source

Involvement of CYP4F2 in the Metabolism of a Novel Monophosphate Ester Prodrug of Gemcitabine and Its Interaction Potential In Vitro

Molecules, 2018
Compound-3 is an oral monophosphate prodrug of gemcitabine. Previous data showed that Compound-3 was more potent than gemcitabine and it was orally active in a tumor xenograft model.
Yedong Wang, Yuan Li, Jia Lu, Huixin Qi, Isabel Cheng, Hongjian Zhang   +5 more
doaj   +1 more source

The prevalence of allelic variants of VKORC1, CYP2C9 and CYP4F2 genes in Zaporizhzhia region population

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019
Objective – to determine the allele frequency of VKORC1, CYP2C9 and CYP4F2 genes in Zaporizhzhia region population. Materials and methods. We investigated 94 individuals at the age of 56 (47; 62) years (men – 23, women – 71) who underwent preventive ...
M. Yu. Kolesnik, Ya. M. Mykhailovskyi
doaj   +1 more source