Results 11 to 20 of about 2,623 (125)
Benchmark of Open-Access Star-Allele Callers to Accurately Assess Haplotypes and Phenotypes in Pharmacogenetic Studies. [PDF]
Clin Pharmacol TherGenetic polymorphisms are common in pharmacogenes, with sometimes important implications for drug metabolism. Assessing the correct enzyme phenotype from genetic data is thus a crucial step into the development of personalized medicine. Many bioinformatics star‐allele callers have been developed for this purpose of identifying the correct star alleles ...
Gros-La-Faige MB, Génin E, Herzig AF.
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Flavonoids as Modulators of Lipid Mediator Signaling: A Narrative Review on Mechanisms, Current Evidence, and Gaps in the Literature. [PDF]
Mol Nutr Food ResFlavonoid consumption may modulate phospholipase activity and COX‐, LOX‐, and CYP450‐dependent oxylipin biosynthesis, reshaping lipid mediator networks. Emerging evidence suggests these shifts may favor inflammatory resolution over propagation, with implications for metabolic, cardiovascular, and neuroinflammatory disease risk.
Arballo J, Lila MA.
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Zaporožskij Medicinskij Žurnal, 2022 The aim. To evaluate the efficacy and safety of warfarin (WF) therapy in patients with atrial fibrillation (AF) using pharmacogenetic dosing method at an anticoagulant monitoring office according to the results of a one-year prospective follow-up ...
M. Yu. Kolesnyk, Ya. M. Mykhailovskyi
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Challenging Anticoagulation With Warfarin and Heparin Following Mechanical Mitral Valve Replacement in a Patient With Infective Endocarditis: A Case Report Highlighting Diagnostic Difficulties. [PDF]
Clin Case RepABSTRACT Warfarin remains the cornerstone of anticoagulation therapy following mechanical heart valve replacement. However, challenging anticoagulation responses, resistance to warfarin, and even more rarely to both warfarin and heparin pose significant clinical challenges and complicate management strategies.
Khan M +9 more
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Respiratory Research, 2020 Background Chronic obstructive pulmonary disease (COPD) is a complex pulmonary disease. Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) belongs to cytochrome P450 superfamily of enzymes responsible for metabolism, its single nucleotide ...
Yipeng Ding +11 more
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Patologìâ, 2022 The aim. To investigate the influence of clinical and genetic factors on the stability of warfarin’s anticoagulant effect in patients with atrial fibrillation (AF) during the year. Materials and methods.
Ya. M. Mykhailovskyi
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Frontiers in Oncology, 2023 BackgroundOur study aimed to explore the potential association of CYP4F2 gene polymorphisms with lung cancer (LC) risk.MethodsThe five variants in CYP4F2 were genotyped using Agena MassARRAY in 507 cases and 505 controls.
Hongyang Shi +4 more
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PLoS ONE, 2023 High altitude pulmonary edema (HAPE) is a common respiratory disease in the high altitude area, which is rapid and harmful. We firstly conducted a case-control study to assess the potential association of CYP4F2 gene polymorphisms with HAPE ...
Lining Si +7 more
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PLoS ONE, 2014 Vitamin E improved liver histology in children and adults with NAFLD who participated in TONIC and PIVENS clinical trials, but with significant inter-individual variability in its efficacy.
Shaminie Athinarayanan +9 more
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EFFECT OF HIGH SALT ON RENAL NKCC2 IN CYP4F2 transgenic mice
Kidney Research and Clinical Practice, 2012 Cytochrome P450 4F2 (CYP4F2) catalyzes the ω-hydroxylation of arachidonic acid (AA) to 20-HETE. We previously generated a CYP4F2 transgenic (TG) mouse model, and demonstrated that overexpressed CYP4F2 elevates 20-HETE production and blood pressure in the
Yanyan Zhao, Jingjing Wu, Guangrei Lai
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