Results 61 to 70 of about 3,566 (133)

VKORC1 and Novel CYP2C9 Variation Predict Warfarin Response in Alaska Native and American Indian People

Clinical and Translational Science, 2019
Alaska Native and American Indian (AN/AI) people have unique pharmacogene variation that may affect warfarin disposition and therapeutic response. We performed targeted genotyping for cytochrome P450 (CYP)2C9, vitamin K epoxide oxidase reductase complex ...
Lindsay M. Henderson, Renee F. Robinson, Lily Ray, Burhan A. Khan, Tianran Li, Denise A. Dillard, Brian D. Schilling, Mike Mosley, Patricia L. Janssen, Alison E. Fohner, Allan E. Rettie, Kenneth E. Thummel, Timothy A. Thornton, David L. Veenstra   +13 more
doaj   +1 more source

The allele frequency of CYP2C9 and VKORC1 in the Southern Khorasan population

Research in Pharmaceutical Sciences, 2017
The genetic factors are determinants in required dosage changes of warfarin among which are polymorphisms of CYP2C9 and VKORC1 genes. The present study aimed to determine the allele and genotype frequency of CYP2C9 and VKORC1 genes in Birjand population.
Fariba Emadian Razavi, Asghar Zarban, Fatemeh Hajipoor, Mohsen Naseri   +3 more
doaj   +1 more source

Genetic factors associated with patient-specific warfarin dose in ethnic Indonesians

BMC Medical Genetics, 2011
Background CYP2C9 and VKORC1 are two major genetic factors associated with inter-individual variability in warfarin dose. Additionally, genes in the warfarin metabolism pathway have also been associated with dose variance.
Utama Andi, Raharjo Sunu B, Wang Tingliang, Tjong Wen, Suriapranata Ivet M, Yuniadi Yoga, Tai Susan SW   +6 more
doaj   +1 more source

Identification of CYP2C9 and VKORC1 polymorphisms in Iranian patients who are under warfarin therapy

International Journal of Hematology-Oncology and Stem Cell Research, 2016
Background: Although catalytic properties of different genetic polymorphisms of VKORC1 and CYP2C9 products have been identified, there is limited study available regarding warfarin dose requirement in Iranian patient population.
Behzad Poopak, Saghar Rabieipoor, Nazila Safari, Emadedin Naraghi, Fatemeh Sheikhsofla, Gelareh Khosravipoor   +5 more
doaj  

Establishment of Acenocoumarol Pharmacogenetic Algorithm Including CYP2C9 and VKORC1 Genotypes in Bulgarian Patients Treated with Coumarin Anticoagulants

Acta Medica Bulgarica
Acenocoumarol, a 4-hydroxycoumarin derivative, is widely prescribed for the primary and secondary prevention of thromboembolic disorders. Maintenance dosing of acenocoumarol is significantly influenced by polymorphic variants in the CYP2C9 and VKORC1 ...
Tzveova R., Saraeva R., Dimitrova-Karamfilova A., Nachev G., Mitev V., Kaneva R., Pendicheva-Duhlenska D.   +6 more
doaj   +1 more source

Polymorphisms of VKORC1 and CYP2C9 are associated with warfarin sensitivity in Chinese population

Therapeutics and Clinical Risk Management, 2017
LiQun Jia,1 Zanxin Wang,1,2 Jianlong Men,3 Heng Cai,4 Minxin Wei2 1Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, 2Department of Cardiac Surgery, Shenzhen Sun Yat-sen Cardiovascular Hospital, Shenzhen ...
Jia LQ, Wang Z, Men J, Cai H, Wei M
doaj  

The role of pharmacogenetics in personalizing anticoagulant therapy: data from the Astrakhan region

Фармация и фармакология (Пятигорск)
The metabolic characteristics of anticoagulants largely depend on the patient’s genetic profile, determining the variability of pharmacological response to drugs and the risk of adverse reactions.
A. N. Romanova, B. I. Kantemirova, O. V. Komarova, N. V. Timofeeva   +3 more
doaj   +1 more source

Gene expression of anticoagulant rodenticide target genes (vkorc1 and vkorc1l1) in a non-target wildlife species: The eagle owl (Bubo bubo)

Ecotoxicology and Environmental Safety
Anticoagulant rodenticides (ARs) are globally used for rodent control, posing significant risks to non-target predators and scavengers through secondary poisoning.
Livia Spadetto, Pilar Gómez-Ramírez, Antonio Juan García-Fernández, Mario León-Ortega, José Manuel Zamora-Marín, Antonio Zamora-López, José Francisco Calvo, José Antonio Rodríguez-Martín, José María Navas, Azucena Bermejo-Nogales   +9 more
doaj   +1 more source

Association between Cytochrome P450 2 C9 and Vitamin K Epoxide Reductase Complex Subunit 1 Polymorphisms with Warfarin dose among Iranian Patients

Research in Molecular Medicine, 2016
Background: Warfarin is a common anticoagulant drug that has a narrow therapeutic index; higher dose causes excessive bleeding and lower dose leads to cerebrovascular clotting and stroke in patients.
Reyhaneh Kameli, Mandana Hasanzad, Zahra Tahmasebi Fard, Mojgan Babanejad, Mahdieh Imeni, Lotfollah Feizi Barnaji, Atoosa Madadkar, Seyed Hamid Jamaldini   +7 more
doaj  

From Frequencies to Priorities: Interethnic Distribution of Pharmacogenetic Phenotypes as a Basis for Prioritizing Preemptive Testing in Russia's Multiethnic Population. [PDF]

Genes (Basel)
Mirzaev KB, Abdullaev SP, Tuchkova SN, Turaev FK, Selivanova LV, Fedorinov DS, Sychev DA.   +6 more
europepmc   +1 more source