Results 61 to 70 of about 3,496 (176)

Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction

Thrombosis Journal, 2008
Background Warfarin treatment has a narrow therapeutic range, requiring meticulous monitoring and dosage titration. Individual dosage requirement has recently partly been explained by genetic variation of the warfarin metabolizing enzyme CYP2C9 and the ...
Seljeflot Ingebjørg, Kierulf Peter, Johansen Per, Sjaatil Stine T, Narum Sigrid, Kringen Marianne K, Sharikabad Mohammad N, Haug Kari, Arnesen Harald, Brørs Odd   +9 more
doaj   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Correction: GGCX and VKORC1 inhibit osteocalcin endocrine functions [PDF]

Journal of Cell Biology, 2019
Vol. 208, No. 6, March 16, 2015. [10.1083/jcb.201409111][1]. The authors noticed a mistake in the labeling of the genotyping primers in Fig. S1 A and Table S1. In Fig. S1 A, the primers P1 and P2 are actually flanking the 5′loxP site region.
Ferron, Mathieu, Lacombe, Julie, Germain, Amélie, Oury, Franck, Karsenty, Gérard   +4 more
openaire   +2 more sources

Single‐Cell Transcriptome‐Wide Mendelian Randomization and Colocalization Uncover Potential Immunocytes‐Related Therapeutic Targets for Obesity

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Weight‐loss treatment is crucial for individuals with obesity to prevent various complications. The role of Immune cells in obesity has been recently recognized, whereas its translation into therapy requires identifying key target genes. We performed Mendelian randomization (MR) analysis to assess causal relationships between expression ...
Xingjian Zhang, Yong Tian, Xiaoying Ren, Juan Tian, Jia Liu, Guang Wang   +5 more
wiley   +1 more source

Identifying the Best Predictive Biomarker in Pharmacogenomics Through Multiple Comparisons With the Best

Biometrical Journal, Volume 68, Issue 2, April 2026.
ABSTRACT Single gene mutations are increasingly being adopted as clinical biomarkers for the optimal application of various therapeutic areas (such as cancer and cardiovascular disease). A single nucleotide polymorphism (SNP), the most common type of genetic variation in human populations, can affect the abundance and function of gene products at the ...
Song Zhai, Judong Shen, Jason C. Hsu, Xinping Cui   +3 more
wiley   +1 more source

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 953-963, April 2026.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Field trials to assess resistance to warfarin and difenacoum of house mice in relation to the occurrence of variants in the vkorc1-gene before and after the treatments

Julius-Kühn-Archiv, 2011
House mice (Mus musculus domesticus) vary considerably in their susceptibility to anticoagulants, and several non-synonymous sequence variants in the coding region of the vitamin K epoxide reductase subcomponent 1 gene (vkorc1) were found in Germany ...
Endepols, S., Klemann, N., Song, Y., Kohn, M. H.   +3 more
doaj   +1 more source

VKORC1 ER mislocalization causes rare disease

Blood, 2014
In this issue of Blood , Czogalla et al identify that the rare heritable hemorrhaging disease, vitamin K–dependent clotting factor deficiency type 2 (VKCFD2), is caused by mislocalization of vitamin K epoxide reductase (VKORC1) in the endoplasmic reticulum (ER).[1][1] ![Figure][2 ...
openaire   +3 more sources

Genotype-phenotype correlations in patients treated with acenocoumarol / Corelaţii genotip-fenotip la pacienţii trataţi cu acenocumarol

Romanian Journal of Laboratory Medicine, 2014
Scop: Această cercetare are drept scop stabilirea unei corelaţii genotip-fenotip la pacienţii trataţi cu acenocumarol şi studierea factoriilor genetici (polimorfismele VKORC1 şi CYP2C9), care ar putea influenţa valorile INR în timpul iniţierii terapiei ...
Militaru Florentina Claudia, Vesa Ştefan Cristian, Crişan Sorin, Militaru Valentin, Trifa Adrian Pavel, Buzoianu Anca Dana   +5 more
doaj   +1 more source

Clinical, manometric, genetic, and histologic associations in pediatric intestinal pseudo‐obstruction: A case series

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 3, Page 660-671, March 2026.
Abstract Objectives Pediatric intestinal pseudo‐obstruction (PIPO) is a severe bowel motility disorder characterized by impaired propulsion of gastrointestinal contents without mechanical obstruction. PIPO encompasses congenital and acquired disorders, including neuropathies, myopathies, and mesenchymopathies.
Sharon Wolfson, Myra Butrviengpunt, Naomi Tjaden, Alain J. Benitez, Archana S. Kota, Jennifer Webster, Prasanna Kapavarapu, Hayat Mousa, Robert O. Heuckeroth   +8 more
wiley   +1 more source