Results 71 to 80 of about 3,496 (176)
Clinical and Translational Science, 2019 Alaska Native and American Indian (AN/AI) people have unique pharmacogene variation that may affect warfarin disposition and therapeutic response. We performed targeted genotyping for cytochrome P450 (CYP)2C9, vitamin K epoxide oxidase reductase complex ...
Lindsay M. Henderson +13 more
doaj +1 more source
Pharmacogenetics of warfarin: A literature review [PDF]
КардиоСоматикаWarfarin is an oral indirect anticoagulant that is widely used for the prevention of thromboembolic events. Pharmacogenetic testing is the most promising approach to personalizing warfarin treatment. In this review, we aimed to summarize how the patients’
Nadezhda V. Izmozherova +4 more
doaj +1 more source
Clinician Satisfaction With Pharmacogenomics Clinical Services at a Multistate Health System
Clinical and Translational Science, Volume 19, Issue 3, March 2026.ABSTRACT Pharmacogenomics (PGx) utilizes genetic information to optimize medication management. Barriers to PGx implementation include limited confidence and knowledge in applying results, time constraints, and financial barriers. Clinical services across health systems vary greatly with differing consultative PGx service models.
Kristen Jacobsen +4 more
wiley +1 more source
Romanian Journal of Laboratory Medicine, 2015 Antagoniștii vitaminei K (AVK) sunt utilizați pe scară largă pentru profilaxia primară și secundară a trombembolismului, efectul lor anticoagulant fiind monitorizat prin intermediul INR.
Brudașcă Ioana
doaj +1 more source
Screening and prevention of anticoagulant resistance development in house mice: A review [PDF]
Pesticidi i Fitomedicina, 2020 Unrestricted use of anticoagulants has resulted in rodents developing resistance to them. This has caused a series of problems regarding reduction in rodent populations, which has further implicated great economic losses and a serious threat to the ...
Blažić Tanja +2 more
doaj
Detection of vkorc1 polymorphism
, 2013 Purpose: The VKORC1 polymorphism is an important genetic factor affecting warfarin dose requirement. Patients require different warfarin doses in order to achieve the target therapeutic anticoagulation. The aim of our study was to determine the frequency of single nucleotide polymorphisms (SNP) in the VKORC1gene in the general population, using a ...
Stangler Herodež, Špela +4 more
openaire +1 more source
Евразийский Кардиологический Журнал, 2019 Анализ взаимосвязи между носительством определенных аллелей полиморфизмов CYP2C9*2 гена CYP2C9 и полиморфного маркера VKORC1 G(-1639)A гена VKORC1 с развитием ЧГ у пациентов узбекской национальности на фоне терапии варфарином (Вф).
doaj
One Rare Warfarin Resistance Case and Possible Mechanism Exploration
Pharmacogenomics and Personalized Medicine, 2023 Li Zhao,1 Zhenguo Zhai,2 Pengmei Li1 1Pharmacy Department, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, People’s Republic of ...
Zhao L, Zhai Z, Li P
doaj
BMC Cardiovascular Disorders, 2018 Background The anticoagulation of atrial fibrillation catheter ablation during the perioperative stage does matter and should be treated with discretion. We aimed to assess impact of three important genes participating in vitamin K cycle (i.e.
Jiao Li +5 more
doaj +1 more source
VKORC1 variants as significant predictors of warfarin dose in Emiratis.
Pharmacogenomics and personalized medicine, 2019 Purpose: Variability in response to warfarin is one of the main obstacles challenging its use in clinical practice. Vitamin K epoxide reductase complex (VKORC) is the target enzyme of warfarin, and variations in the form of single nucleotide polymorphisms (SNPs) in VKORC1, coding for this enzyme, are known to cause resistance to warfarin treatment ...
Al-Mahayri,Zeina N +6 more
openaire +3 more sources