Results 51 to 60 of about 3,496 (176)

Positive selection in the chromosome 16 VKORC1 genomic region has contributed to the variability of anticoagulant response in humans. [PDF]

PLoS ONE, 2012
VKORC1 (vitamin K epoxide reductase complex subunit 1, 16p11.2) is the main genetic determinant of human response to oral anticoagulants of antivitamin K type (AVK).
Blandine Patillon, Pierre Luisi, Hélène Blanché, Etienne Patin, Howard M Cann, Emmanuelle Génin, Audrey Sabbagh   +6 more
doaj   +1 more source

Distribution and frequency of Vkorc1 polymorphisms in house mice and Norway rats in the northeastern United States

Pest Management Science, Volume 82, Issue 8, Page 7700-7710, August 2026.
This study assesses the distribution and frequency of Vkorc1 polymorphisms in house mice and Norway rats in northeastern USA. House mice showed higher frequency of Vkorc1 mutations than Norway rats. The A32V and Y139F mutations are first reported in mice, and the L128V is newly reported in Norway rats.
Jin‐Jia Yu, Alvaro Toledo, Adrienne E Kasprowicz, Megan V Phifer‐Rixey, Xiaodan Pan, Babatunji Daramola, Changlu Wang   +6 more
wiley   +1 more source

Missense mutation of VKORC1 leads to medial arterial calcification in rats

Scientific Reports, 2018
Vitamin K plays a crucial role in the regulation of vascular calcifications by allowing activation of matrix Gla protein. The dietary requirement for vitamin K is low because of an efficient recycling of vitamin K by vitamin K epoxide reductase (VKORC1).
Arnaud Michaux, Benjamin Matagrin, Jean-Valéry Debaux, Leon J. Schurgers, Etienne Benoit, Virginie Lattard   +5 more
doaj   +1 more source

Polymorphism of the CYP2C9 and VKORC1 genes: a comment [PDF]

Jornal Vascular Brasileiro, 2021
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit, Christiane de Fátima Colet   +2 more
openaire   +4 more sources

Characterization of the VKORC1 and CYP2C9 genotypes v6

, 2023
Vitamin K antagonists (e.g. warfarin) are anticoagulants which represent widely prescribed drugs for prevention and treatment of thromboembolic disorders. Warfarin's molecular target is vitamin K epoxide reductase enzyme and its metabolism is performed by the cytochrome P-450 2C9 enzyme, both of which are encoded by polymorphic genes - vitamin K ...
Mirsada Causevic, Honours BSc, PhD, Edin Begic   +1 more
openaire   +1 more source

Next‐Generation Surgery: Integrating Artificial Intelligence, Genetic Technologies, Bioengineering and Rehabilitation Into Modern Practices

Exploration, Volume 6, Issue 3, June 2026.
This graphic abstract depicts the convergence of artificial intelligence, genetic technologies, bioengineering, and rehabilitation as the core pillars of next‐generation surgery. These domains collectively enhance preoperative planning, intraoperative precision, tissue reconstruction, and postoperative recovery, driving a paradigm shift toward ...
Dengxiong Li, Jie Wang, Zhipeng Wang, Ruicheng Wu, Zhouting Tuo, Fanglin Shao, Wenjing Ge, Ziyu Shu, Yubo Yang, Dilinaer Wusiman, Qingxin Yu, Luxia Ye, Alisha Pati‐Alam, Facai Zhang, Koo Han Yoo, Susan Heavey, William C. Cho, Dechao Feng   +17 more
wiley   +1 more source

Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study

Clinics, 2019
OBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with ...
Merih Ozgen, Didem Turgut Cosan, Fulya Doganer, Ahu Soyocak, Onur Armagan, Selen Kuzgun, Ayse Merve Aydogan, Hasan Veysi Gunes, Irfan Degirmenci, Fezan Mutlu   +9 more
doaj   +1 more source

The prevalence of VKORC1 alleles in the population of the Republic of Srpska, Bosnia and Herzegovina [PDF]

Scripta Medica, 2023
Background/Aim: Warfarin is one of the most common orally prescribed anticoagulant in patients with deep venous thrombosis, myocardial or cerebral infarctions. The main side effects of non-adequate dose of these drugs are prolonged peripheral or internal
Vidović Vanja, Bećarević Jelena, Radić-Savić Žana, Marić Aljoša, Vidović Stojko, Milovac Irina, Maksimović Nela   +6 more
doaj  

Risk of hemorrhagic stroke in warfarin‐treated patients following heart valve replacement: Findings from the MAGPIE study

Ibrain, Volume 12, Issue 2, Page 250-258, Summer 2026.
Among 568 mechanical heart valve replacement patients in Bangladesh, hemorrhagic stroke occurred in 4.4% with 52% mortality. Severe pulmonary hypertension increased risk 4.4‐fold, and warfarin therapy ≥104 months nearly doubled the risk, highlighting the need for long‐term risk monitoring in anticoagulated valve patients.
Dipannita Adhikary, Md. Abdullah Yusuf, AM Nayeem Parvez, Sheikh M. B. Faruque, Santo Barman, Adneen Moureen, Luke J. Rogers, Aziz Momin, Venkatachalam Chandrasekaran, Asit B. Adhikary, Redoy Ranjan   +10 more
wiley   +1 more source

Polymorphisms of genes CYP2C9 and VKORC1 in patients with venous thromboembolic complications in Moscow population: effects on stability of anticoagulant therapy and frequency of hemorrhage

Терапевтический архив, 2011
Aim. To investigate frequency of carriage of genetic polymorphisms CYP2C9 and VKORC1 in patients with venous thromboembolic complications (VTEC) in Moscow population given warfarin treatment and effects of this carriage on stability of anticoagulation ...
Natal'ya Mikhaylovna Vorob'eva, Elizaveta Pavlovna Panchenko, Anatoliy Borisovich Dobrovol'skiy, Elena Vladimirovna Titaeva, Zukhra Bilyalovna Khasaeva, Nina Valer'evna Konovalova, Anton Yuvenal'evich Postnov, Aleksandr Ivanovich Kirienko, N M Vorobyeva, E P Panchenko, A B Dobrovolsky, E V Titaeva, Z B Khasaeva, N V Konovalova, A Yu Postnov, A I Kirienko   +15 more
doaj