Results 31 to 40 of about 3,566 (133)

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3716-3732, November 2026.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

Stability of Anticoagulation Following Acenocoumarin in Stroke Patients: Role of Pharmacogenomics and Acquired Factors

Annals of Indian Academy of Neurology
Objective: Pharmacogenomics plays an important role in drug metabolism. A stable anticoagulation is important for primary and secondary prevention of cardioembolic stroke and cerebral venous sinus thrombosis (CVST). We report the role of cytochrome P450 (
Ashish Kant Dubey, Jayantee Kalita, Mohammad Firoz Nizami, Surendra Kumar, Usha Kant Misra   +4 more
doaj   +1 more source

Genetic Polymorphism Effect on Warfarin–Rifampin Interaction: A Case Report and Review of Literature

Pharmacogenomics and Personalized Medicine, 2021
Muhammad Salem,1 Islam Eljilany,2 Ahmed El-Bardissy,1 Hazem Elewa2,3 1Department of Pharmacy, Hamad General Hospital, Doha, Qatar; 2College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 3Biomedical and Pharmaceutical Research Unit, QU Health ...
Salem M, Eljilany I, El-Bardissy A, Elewa H   +3 more
doaj  

Integrated scRNA‐Seq and Spatial Transcriptomics Reveal CHPF and GPC1 as Markers of Cancer‐Associated Fibroblast–Dominant Domains in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Spatial heterogeneity in the colorectal cancer (CRC) tumor microenvironment (TME) is closely related to stromal organization and may influence treatment‐related features. In this study, we integrated single‐cell RNA sequencing and spatial transcriptomic data from CRC tissues to examine cancer‐associated fibroblast (CAF)‐dominant spatial ...
Yuan‐jie Liu, Qian‐wen Ye, Hui Zhang, Ning Yang, Yang Li, Jie‐pin Li   +5 more
wiley   +1 more source

From Genomics to Precision Cardiology: A Comprehensive Review of Clinical Applications and Challenges in Cardiovascular Diseases

Clinical Cardiology, Volume 49, Issue 10, October 2026.
Genomic medicine in cardiovascular care is progressing from established diagnostic applications toward integrated risk prediction, multiomics, and emerging therapeutic strategies. ABSTRACT Background Genomic cardiology is an emerging field integrating genetic, molecular, imaging, and digital health data to improve cardiovascular disease (CVD ...
Neda Mohsen‐Pour, Shiva Esmaeili, Aydin Feyzi, Ali Sharafi, Majid Maleki, Samira Kalayinia   +5 more
wiley   +1 more source

Missense mutation of VKORC1 leads to medial arterial calcification in rats

Scientific Reports, 2018
Vitamin K plays a crucial role in the regulation of vascular calcifications by allowing activation of matrix Gla protein. The dietary requirement for vitamin K is low because of an efficient recycling of vitamin K by vitamin K epoxide reductase (VKORC1).
Arnaud Michaux, Benjamin Matagrin, Jean-Valéry Debaux, Leon J. Schurgers, Etienne Benoit, Virginie Lattard   +5 more
doaj   +1 more source

Warfarin anticoagulant therapy: a Southern Italy pharmacogenetics-based dosing model.

PLoS ONE, 2013
Background and aimWarfarin is the most frequently prescribed anticoagulant worldwide. However, warfarin therapy is associated with a high risk of bleeding and thromboembolic events because of a large interindividual dose-response variability.
Cristina Mazzaccara, Valeria Conti, Rosario Liguori, Vittorio Simeon, Mario Toriello, Angelo Severini, Corrado Perricone, Alfonso Meccariello, Pasquale Meccariello, Dino Franco Vitale, Amelia Filippelli, Lucia Sacchetti   +11 more
doaj   +1 more source

The prevalence of VKORC1 alleles in the population of the Republic of Srpska, Bosnia and Herzegovina [PDF]

Scripta Medica, 2023
Background/Aim: Warfarin is one of the most common orally prescribed anticoagulant in patients with deep venous thrombosis, myocardial or cerebral infarctions. The main side effects of non-adequate dose of these drugs are prolonged peripheral or internal
Vidović Vanja, Bećarević Jelena, Radić-Savić Žana, Marić Aljoša, Vidović Stojko, Milovac Irina, Maksimović Nela   +6 more
doaj  

Positive selection in the chromosome 16 VKORC1 genomic region has contributed to the variability of anticoagulant response in humans. [PDF]

PLoS ONE, 2012
VKORC1 (vitamin K epoxide reductase complex subunit 1, 16p11.2) is the main genetic determinant of human response to oral anticoagulants of antivitamin K type (AVK).
Blandine Patillon, Pierre Luisi, Hélène Blanché, Etienne Patin, Howard M Cann, Emmanuelle Génin, Audrey Sabbagh   +6 more
doaj   +1 more source

Comparison of pharmacogenomic guidance in Australian prescribing resources and international pharmacogenomic guidelines

Internal Medicine Journal, Volume 56, Issue 10, Page 1765-1774, October 2026.
Abstract Background Pharmacogenomic‐guided medication management optimises drug therapy to enhance patient outcomes. Despite clinical utility, implementation in Australia remains limited, partly due to the lack of clear and consistent guidance. Aim This study evaluated the presence and consistency of pharmacogenomic testing indication categories and ...
Ruby Soueid, Jackson L. A. Thomas, Luke B. Hesson, Stephen Hughes, Sophie L. Stocker   +4 more
wiley   +1 more source