Results 21 to 30 of about 3,496 (176)

VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites

Blood Advances, 2018
: Vitamin K reduction is catalyzed by 2 enzymes in vitro: the vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) and its isozyme VKORC1-like1 (VKORC1L1). In vivo, VKORC1 reduces vitamin K to sustain γ-carboxylation of vitamin K-dependent proteins,
Katrin J. Czogalla, Kerstin Liphardt, Klara Höning, Veit Hornung, Arijit Biswas, Matthias Watzka, Johannes Oldenburg   +6 more
doaj   +1 more source

Effects of CYP2C9 and VKORC1 polymorphisms on warfarin sensitivity and responsiveness during the stabilization phase of therapy

Saudi Pharmaceutical Journal, 2019
The main objective of this study is to assess the effects of CYP2C9 and VKORC1 polymorphisms on warfarin sensitivity and responsiveness in a Jordanian population during the stabilization phase of treatment.
Laith N. AL-Eitan, Ayah Y. Almasri, Rame H. Khasawneh   +2 more
doaj   +1 more source

Analysis of vkorc1 polymorphisms in Norway rats using the roof rat as outgroup

BMC Genetics, 2010
Background Certain mutations in the vitamin K epoxide reductase subcomponent 1 gene (vkorc1) mediate rodent resistance to warfarin and other anticoagulants. Testing for resistance often involves analysis of the vkorc1.
Borchert Jeff N, Moore Anthony, Song Ying, Díaz Juan C, Kohn Michael H   +4 more
doaj   +1 more source

A cardiovascular phenotype in warfarin-resistant Vkorc1 mutant rats☆

Artery Research, 2008
Background: The inhibition of the vitamin K cycle by warfarin promotes arterial calcification in the rat. Conceivably, genetically determined vitamin K deficiency owing to a mutant epoxide reductase subcomponent 1 (Vkorc1) gene, a key component of the ...
Michael H. Kohn, Roger E. Price, Hans-Joachim Pelz   +2 more
doaj   +1 more source

Structural Modeling Insights into Human VKORC1 Phenotypes [PDF]

Nutrients, 2015
Vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) catalyses the reduction of vitamin K and its 2,3-epoxide essential to sustain γ-carboxylation of vitamin K-dependent proteins. Two different phenotypes are associated with mutations in human VKORC1.
Czogalla, Katrin J., Watzka, Matthias, Oldenburg, Johannes   +2 more
openaire   +2 more sources

The efficacy of low-dose warfarin initiation (3 mg versus 5 mg) in newly diagnosed venous thromboembolism patients among a population with a high prevalence of warfarin-sensitive haplotype of the VKORC1 gene: a randomized controlled trial

Hematology, 2022
Objectives The fact that a lower warfarin maintenance dose is required by Asian populations is well-known. Currently, the American College of Chest Physicians recommends commencing warfarin at a dose between 5 and 10 mg for venous thromboembolism (VTE ...
Bundarika Suwanawiboon, Wannaphorn Rotchanapanya, Komkrit Mahaprom, Wanna Thongnoppakhun, Yupaporn Lalerd, Chanin Limwongse, Nuttawut Sermsathanasawadi, Weerapat Owattanapanich   +7 more
doaj   +1 more source

Characterization of the VKORC1 and CYP2C9 genotypes v2

, 2023
Vitamin K antagonists are anticoagulants which represent widely prescribed drugs for prevention and treatment of thromboembolic disorders. The molecular target of these drugs is vitamin K epoxide reductase enzyme and their metabolism is performed by the cytochrome P-450 2C9 enzyme, both of which are encoded by polymorphic genes - vitamin K epoxide ...
Mirsada Causevic, Honours BSc, PhD, Edin Begic   +1 more
openaire   +1 more source

The Effect of CYP2C9 and VKORC1 Genetic Polymorphism on Warfarin Dose Requirements in a Sample of Iraqi Patients [PDF]

Journal of Kerman University of Medical Sciences, 2021
Background: Warfarin is the most widely used oral anticoagulant for the prevention and treatment of thromboembolic disorders. Because of narrow therapeutic index and various genetic and non-genetic factors that influence the disposition of the drug, its ...
Maha Ali Saleh, Haitham Mahmood Kadhim, Ahmed Sahib, Ahmed S Abdulamir, Rafed Altawil   +4 more
doaj   +1 more source

VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey.

PLoS ONE, 2010
Osteoporosis, defined by low bone mineral density (BMD), is common among postmenopausal women. The distribution of BMD varies across populations and is shaped by both environmental and genetic factors.
Dana C Crawford, Kristin Brown-Gentry, Mark J Rieder   +2 more
doaj   +1 more source

Implications of Polymorphisms in the BCKDK and GATA‐4 Gene Regions on Stable Warfarin Dose in African Americans

Clinical and Translational Science, 2021
VKORC1 and CYP2C9 genotypes explain less variability in warfarin dose requirements in African Americans compared with Europeans. Variants in BCKDK and GATA‐4 gene regions, purported to regulate VKORC1 and CYP2C9 expression, have been shown to play an ...
Salma A. Bargal, Jennifer N. Kight, Felipe Augusto de Oliveira, Mohamed H. Shahin, Taimour Langaee, Yan Gong, Issam S. Hamadeh, Rhonda M. Cooper-DeHoff, Larisa H. Cavallari   +8 more
doaj   +1 more source