Results 161 to 170 of about 185,181 (328)

Opportunities and Challenges of Population Pharmacogenomics

Annals of Human Genetics, EarlyView.
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou, Yoomi Park, Mahamadou D. Camara, Volker M. Lauschke   +3 more
wiley   +1 more source

Alternative therapy interaction with warfarin: what doctors should know

Кардиоваскулярная терапия и профилактика, 2010
Warfarin effectiveness and safety is substantially affected by concurrent therapy. This paper reviews the main mechanisms of warfarin interactions with other agents, which underlie adverse effect development: platelet dysfunction, gastro-intestinal ...
T. B. Kozlova, T. V. Taratuta, M. B. Aksenova, T. V. Khlevchuk   +3 more
doaj  

Embedding Pharmacogenetics Into Clinical Practice to Improve Patient Outcomes

Annals of Human Genetics, EarlyView.
ABSTRACT Pharmacogenomics, the use of germline genomic data to guide prescription to improve effective and safer medication, holds promise as a clinical intervention. To date in most health systems, there has been limited uptake of pharmacogenomic testing confined to a few single drug–gene associations.
John Henry McDermott, Videha Sharma, Jessica Keen, William Gerard Newman   +3 more
wiley   +1 more source

Early use of non‐vitamin K antagonist oral anticoagulants after cardiac surgery compared with warfarin for postoperative atrial fibrillation

ANZ Journal of Surgery, EarlyView.
With the increasing use of NOAC and the availability of reversal agents, there remains sparse evidence regarding its use in POAF. The use of a NOAC in patients with POAF did not appear to increase short‐term postoperative complications, including bleeding, stroke, readmission rates and mortality, compared with warfarin.
Shantel Chang, Alexander Lombardo, Ian Smith, Samuel Lawler, Cheng He, Andrie Stroebel   +5 more
wiley   +1 more source

Influence of Preoperative Anatomical Characteristics on the Direction of Inflow Cannula in HeartMate 3

Artificial Organs, EarlyView.
The IC direction in HM3 was influenced by the mitral valve height from the LV apex, distance between the LV apex and chest wall, and thoracic depth from the LV apex. Moreover, the IC direction in HM3 had little influence on the flow, PAWP and the survival rate of patients.
Shusuke Imaoka, Daisuke Yoshioka, Shunsuke Saito, Takuji Kawamura, Ai Kawamura, Ryohei Matsuura, Yusuke Misumi, Koichi Toda, Shigeru Miyagawa   +8 more
wiley   +1 more source

Impact of age and time since diagnosis on thrombosis risk in myeloproliferative neoplasm patients: A nationwide register‐based matched cohort study

British Journal of Haematology, EarlyView.
This study investigates the rate of thrombosis in patients with myeloproliferative neoplasms (MPNs) using population‐based data from Swedish registers. The research focuses on whether attained age or time since diagnosis plays a more significant role in thrombosis risk.
Nurgul Batyrbekova, Malin Hultcrantz, Anna Ravn Landtblom, Robert Szulkin, Paul W. Dickman, Therese M.‐L. Andersson, Elisavet Syriopoulou   +6 more
wiley   +1 more source

Warfarin and extraction [PDF]

British Dental Journal, 2003
openaire   +2 more sources

Magnetic resonance imaging‐guided transurethral ultrasound ablation for benign prostatic obstruction: 1‐year clinical outcomes of a phase II study

BJU International, EarlyView.
Objectives To evaluate the safety and efficacy of magnetic resonance imaging (MRI)‐guided transurethral ultrasound ablation (TULSA) as a minimally invasive alternative for benign prostatic obstruction (BPO). Patients and Methods This prospective, single‐centre, early phase II study (NCT03350529) included 30 men with BPO scheduled for primary ...
Antti Viitala, Mikael Anttinen, Pietari Mäkelä, Heikki Pärssinen, Pertti Nurminen, Teija Sainio, Jani Saunavaara, Pekka Taimen, Roberto Blanco Sequeiros, Peter J. Boström   +9 more
wiley   +1 more source

Correlation between Metabolic Parameters and Warfarin Dose in Patients with Heart Valve Replacement of Different Genotypes

Reviews in Cardiovascular Medicine
Background: Warfarin has become the first choice for anticoagulation in patients who need lifelong anticoagulation due to its clinical efficacy and low price.
Xiaowu Wang, Diancai Zhao, Jipeng Ma, Xia Wang, Jincheng Liu   +4 more
doaj   +1 more source

Pathogenic variants in chromatin‐related genes: Linking immune dysregulation to neuroregression and acute neuropsychiatric disorders

Developmental Medicine &Child Neurology, EarlyView.
Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐related genes: MORC2, CHD7, KANSL1, KMT2D, ZMYND11, HIST1HIE, EP300, and KMT2B.
Russell C. Dale, Shekeeb Mohammad, Velda X. Han, Hiroya Nishida, Himanshu Goel, Stuart G. Tangye, Georgina Hollway, Esther Tantsis, Deepak Gill, Shrujna Patel, Chromatin Immune‐Brain Group, Michael Lonergan, Melanie Wong, Kavitha Kothur, Erica Tsang   +14 more
wiley   +1 more source