Results 171 to 180 of about 94,071 (310)

Challenging Anticoagulation With Warfarin and Heparin Following Mechanical Mitral Valve Replacement in a Patient With Infective Endocarditis: A Case Report Highlighting Diagnostic Difficulties. [PDF]

Clin Case Rep
Khan M, Ahmad A, Khan M, Zainullah FNU, Khan N, Nazir F, Ahmed W, Ullah N, Anees M, Kamil KA.   +9 more
europepmc   +1 more source

Early Versus Late Wake‐Up Call After Out‐Of‐Hospital Cardiac Arrest: Protocol for a Multicenter Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest (DANOHCA) Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Survivors of out‐of‐hospital cardiac arrest (OHCA) who remain comatose after return of spontaneous circulation are routinely sedated and mechanically ventilated during early post‐resuscitation care. Although prolonged sedation has traditionally been considered necessary, contemporary normothermia‐based temperature control allows ...
Anders Morten Grejs, Jesper Kjaergaard, Jo Bønding Andreasen, Bodil Steen Rasmussen, Christian Hassager, Martin Abild Stengaard Meyer, Lars Peter Kloster Andersen, Henrik Schmidt, Simon Moelstroem, Sören Möller, Christhopher Torp, Steffen Christensen, Jacob Eifer Moeller   +12 more
wiley   +1 more source

Taste-Masked Microparticles of Sodium Warfarin Prepared by Hot Melt Extrusion and Thermal Postprocessing. [PDF]

Pharmaceutics
Kaufelde P, Aniskevich A, Sevcenko J, Žogota M, Horváth ZM, Mohylyuk V.   +5 more
europepmc   +1 more source

Genomic and Sex Contributions to Interindividual Variability in Pitavastatin Bioavailability

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT Aim This study investigates pharmacogenetic determinants of pitavastatin disposition using a candidate‐gene approach. Methods In 48 healthy volunteers, 138 variants across 40 genes involved in drug metabolism and transport were analysed to assess their relationship with pitavastatin pharmacokinetics, alongside the influence of sex and ...
Eva González‐Iglesias, Sofía Moreno‐Pérez de Villar, Dolores Ochoa, Manuel Román, Jesús Novalbos, Samuel Martín‐Vilchez, Alejandro de Miguel, Francisco Abad‐Santos   +7 more
wiley   +1 more source

Association of SGLT2 Inhibitor With Stroke in Type 2 Diabetes With Diabetic Retinopathy: A Multicenter Electronic Health Record Data Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5614-5626, July 2026.
ABSTRACT Aims Diabetic retinopathy (DR) is linked to elevated risks of cerebrovascular diseases. Whether sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) reduce stroke risk in patients with type 2 diabetes (T2D) and DR remains uncertain. Materials and Methods We conducted a retrospective cohort study using the TriNetX Research Network.
Kuo‐En Chen, Po‐Chun Wang, Hui‐An Lin, Sheng‐Feng Lin   +3 more
wiley   +1 more source

From "negative" trial to positive clinical impact: mitigating eligibility criteria-induced temporal selection bias in emulated clinical trials. [PDF]

Npj Health Syst
Li X, Rajaganapathy S, Hu X, Lee M, Feng J, Li J, Yu Y, Fiero P, Boroumand S, Larsen R, Chen J, Li P, James J, Liu X, Tao C, Zong N.   +15 more
europepmc   +1 more source

A Descriptive Analysis of Potential Warfarin-NSAID Interactions in Dental Prescribing in Minas Gerais, Brazil, 2011-2021. [PDF]

Healthcare (Basel)
Reis-Oliveira J, Cruz AJSD, Garcez WEPB, Santos JS, Martins MAP, Abreu MHNG.   +5 more
europepmc   +1 more source

Anticoagulation associated intracerebral haemorrhage trends, treatment and outcomes in a metropolitan cohort: analysed by availability of specific versus non-specific reversal agents. [PDF]

BMJ Neurol Open
El-Masri S, Goh R, Bacchi S, Tamlin L, Sulley-Beales N, Chen S, Howson S, Stretton B, Zweck D, Willcourt M, Moey A, Jannes J, Kleinig T.   +12 more
europepmc   +1 more source

Infrared Spectroscopy of Amide Modes in Peptides: Experimental FTIR and QM/MM Protocol Insights

ChemPhysChem, Volume 27, Issue 11, 15 June 2026.
A multiscale QM/MM framework unlocks the structural code hidden in peptide IR spectra. By treating the sensitive amide vibrations quantum‐mechanically within a realistic protein environment, we accurately simulate spectral features, directly linking vibrational fingerprints to secondary structure and conformational dynamics.
Valdecir F. Ximenes, Carmen R. de Souza, Aguinaldo R. de Souza, Nelson H. Morgon   +3 more
wiley   +1 more source

Hofmann Degradation of Asparagine and Glutamine as an Efficient Approach for the Synthesis of Derivatized Lysine Homologs

European Journal of Organic Chemistry, Volume 29, Issue 21, 4 June 2026.
A practical and scalable route to C1 and C2 lysine homologs has been developed using Hofmann degradation of N‐protected L‐asparagine and L‐glutamine as the key step. These short‐tether scaffolds enable efficient synthesis of diverse Fmoc‐protected noncanonical amino acids (ncAAs) bearing donor, acceptor, redox‐active, and fluorescent residues.
Adelaide R. Mashweu, François J. De Beer, Jolien Bertouille, Steven Ballet, Charlotte Martin, Ulrich Hennecke, Charlene Marais, Vladimir A. Azov   +7 more
wiley   +1 more source