Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods
Chirality, Volume 38, Issue 7, July 2026.Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz +1 more
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Anticoagulant Procedure in Hospital Environment
, 2019 Different anticoagulants are given depending on many factors. usually warfarin is preferred in long term treatment specially if there is atrial fibrillation or prosthetic vavlve, if not direct thrombin inhibitor or factor Xa inhibitor can be given ...
El Orra, Youssef
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Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 168-177, July 2026.Target trial emulation of a multi‐institutional electronic health record network showed comparable cardiorenal effectiveness and safety of dapagliflozin versus empagliflozin in adults with type 2 diabetes and advanced‐stage chronic kidney disease.
Shih‐Hsuan Lin +6 more
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Prescribing Caution: A Critique of OpenEvidence to Answer Medication‐Related Questions
JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 7, July 2026.ABSTRACT OpenEvidence is a newer medical large language model (LLM) that is growing in use among health professionals and students for clinical care and research. This paper provides an overview of existing literature on the accuracy of using OpenEvidence to answer clinical questions.
Jessica M. Bergsbaken +4 more
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Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
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Absence of pharmacovigilance signals for bleeding events associated with warfarin-SSRI drug interactions: a comparative analysis of FAERS and CVARD databases. [PDF]
Ther Adv Drug SafZhang P, Cheng S, Diao J, Zhu H.
europepmc +1 more source
Naoxintong Is Involved in the Coagulation Regulation of Warfarin Through the MAPK Pathway
Xiao Luo,1,2,* Ling Chen,2,* Jingsong Xu,1 Juxiang Li1 1Department of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330000, People’s Republic of China; 2Department of ...
Li J, Chen L, Luo X, Xu J
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Airway Involvement in Conradi–Hünermann–Happle Syndrome: A Novel Clinical Manifestation
The Laryngoscope, Volume 136, Issue 7, Page 3240-3245, July 2026.We report the first documented case of airway involvement in Conradi–Hünermann–Happle syndrome (CDPX2), an X‐linked dominant form of chondrodysplasia punctata caused by pathogenic variants in EBP. A 2‐month‐old female with genetically confirmed CDPX2 developed severe subglottic stenosis and persistent respiratory distress requiring CPAP; cross ...
Enrique G. Villarreal +3 more
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Divergent Small Vessel Disease Burden in Warfarin-Associated and Direct Oral Anticoagulant-Associated Intracerebral Hemorrhage. [PDF]
J StrokeTang SC +8 more
europepmc +1 more source
Protein and Peptide Inhibitors of Mineralization: A Systematic Review of In Vitro Studies
Journal of Peptide Science, Volume 32, Issue 7, July 2026.In vitro evidence from crystallization assays demonstrates that peptides inhibit mineral nucleation and crystal growth through sequence‐dependent interactions (acidic residues and phosphorylation) with mineral surfaces. In cell cultures, these molecules reduce calcium deposition and ALP activity and modulate the expression of biomineralization‐related ...
Alberto Mimila‐Cortes +7 more
wiley +1 more source