Results 171 to 180 of about 185,181 (328)
In a cohort of 155,152 patients with atrial fibrillation, heart failure and low body weight, patients weighting <60 kg faced a higher risk of adverse events compared to those in the reference BW (60–100 kg), regardless of treatment. Apixaban demonstrated a lower risk of ischaemic stroke/systemic embolism, bleedings (including intracranial hemorrhage ...
Luca Monzo+6 more
wiley +1 more source
Economic burden of adverse drug reactions and potential for pharmacogenomic testing in Singaporean adults. [PDF]
Adverse drug reactions (ADRs) contribute to hospitalization but data on its economic burden is scant. Pre-emptive pharmacogenetic (PGx) testing can potentially reduce ADRs and its associated costs.
Brunham, Liam R+6 more
core +1 more source
ABSTRACT Introduction Patients with severe Factor XI deficiency face unique challenges during urological procedures due to an elevated risk of bleeding, balanced against the use of tranexamic acid (TXA), which may form blood clots. Given the limitations associated with plasma‐based treatment, there have been reports of successful and safe off‐label use
Neta Sternbach+7 more
wiley +1 more source
Abstract Aim Antithrombin (AT), a plasma protein with anticoagulant properties, has a long‐standing medical history, primarily for treatment of congenital AT deficiency. Accumulated clinical experiences suggest AT is a potential anticoagulant for thrombotic diseases. This study aimed to clarify the effectiveness, safety, and clinical significance of AT
Shoichi Matsutani+2 more
wiley +1 more source
Activated Protein C Resistance Testing: An Update From Australasia/Asia‐Pacific
ABSTRACT Introduction Activated protein C resistance (APCR) represents a risk factor for thrombosis and is usually due to factor V Leiden (FVL). Clinicians may order either test (i.e., APCR or FVL) to help assess ‘thrombophilia’ in patients who present with thrombosis. APCR testing is usually achieved using clot‐based assays, whereas FVL is assessed by
Emmanuel J. Favaloro+8 more
wiley +1 more source
Bound to bleed: How altered albumin binding may dictate warfarin treatment outcome
Although non-vitamin-K anticoagulants are now the preferred option for stroke prevention in atrial fibrillation (AF), warfarin is still used in a significant number of patients.
Anke C. Fender, Dobromir Dobrev
doaj
Measuring Direct Oral Anticoagulant (DOAC) Levels: Applications, Limitations, and Future Directions
ABSTRACT Introduction There are important challenges with the measurement and interpretation of direct oral anticoagulant (DOAC) anticoagulant effect including a lack of therapeutic ranges, inaccuracy of routinely available coagulation assays, lack of established thresholds for clinically significant effect, and uncertainty about how to apply the ...
Siraj Mithoowani+2 more
wiley +1 more source