Results 301 to 310 of about 192,309 (409)

Lack of Pharmacokinetic Drug–Drug Interactions Between Bepirovirsen and Nucleos(t)ide Analogs

Clinical Pharmacology in Drug Development, Volume 14, Issue 4, Page 281-291, April 2025.
Abstract Bepirovirsen is an antisense oligonucleotide currently in Phase 3 development to treat chronic hepatitis B virus (HBV) infection. Given the importance of coadministration of bepirovirsen and standard‐of‐care nucleos(t)ide analogs (NAs), we evaluated drug–drug interactions (DDIs) between bepirovirsen, entecavir (ETV), and tenofovir (TFV) using ...
Kelong Han, Amir S. Youssef, Mindy Magee, Steve Hood, Helen Tracey, Jesse Kwoh, Dickens Theodore, Melanie Paff, Ahmed Nader   +8 more
wiley   +1 more source

Secondary prevention with antiplatelet medications in patients with antiphospholipid antibody-related stroke. [PDF]

Sci Rep
Yang W, Chung M, Ha J, Kang DW, Lee EJ, Jeong HY, Kim JM, Jung KH, Lee SH.   +8 more
europepmc   +1 more source

Concomitant Use of Oral Anticoagulants With Oral Dipeptidyl Peptidase‐4 Inhibitors and Serious Bleeding Events

Clinical Pharmacology &Therapeutics, Volume 117, Issue 4, Page 1012-1016, April 2025.
In a prior screening study, saxagliptin, a dipeptidyl peptidase‐4 inhibitor (DPP‐4i), was found to have an increased rate of serious bleeding when used concomitantly with several oral anticoagulants (OACs). We aimed to confirm or refute the associations between concomitant use of individual OACs and DPP‐4is and serious bleeding in a large US database ...
Thanh Phuong Pham Nguyen, Charles E. Leonard, Colleen M. Brensinger, Warren B. Bilker, Sophie P. Chung, John R. Horn, Kacie Bogar, Todd A. Miano, Sean Hennessy   +8 more
wiley   +1 more source

Prolonged Prothrombin Time due to Drug-Drug Interaction of Warfarin after the Change from Bosentan to Macitentan: A Case of Pharmacist Intervention in the Outpatient Clinic. [PDF]

Kobe J Med Sci
Kurimura T, Omura T, Yamamoto K, Tanaka H, Kimura T, Itohara K, Kitahiro Y, Habu Y, Sakane T, Yano I.   +9 more
europepmc   +1 more source

Discovering Severe Adverse Reactions From Pharmacokinetic Drug–Drug Interactions Through Literature Analysis and Electronic Health Record Verification

Clinical Pharmacology &Therapeutics, Volume 117, Issue 4, Page 1078-1087, April 2025.
While drug–drug interactions (DDIs) and their pharmacokinetic (PK) mechanisms are well‐studied prior to drug approval, severe adverse drug reactions (SADRs) caused by DDIs often remain underrecognized due to limitations in pre‐marketing clinical trials.
Eugene Jeong, Yu Su, Lang Li, You Chen
wiley   +1 more source

Comparing the post-operative complications following surgery for hip fracture of patients who were on warfarin versus patients who were on novel oral anticoagulants: a meta-analysis. [PDF]

Perioper Med (Lond)
Wei Y, Chen C, Yu Z, Guo J.
europepmc   +1 more source

Safety and efficacy of low‐power pure‐cut hot snare polypectomy for small nonpedunculated colorectal polyps compared with conventional resection methods: A propensity score matching analysis

DEN Open, Volume 5, Issue 1, April 2025.
Abstract Objectives Cold snare polypectomy (CSP) is widely performed for small colorectal polyps. However, small colorectal polyps sometimes include high‐grade adenomas or carcinomas that require endoscopic resection with electrocautery. This study aimed to evaluate the efficacy and safety of a novel resection technique, hot snare polypectomy with low ...
Hidenori Kimura, Masayuki Oi, Kenichiro Imai, Takayuki Imai, Yukihiro Morita, Atsushi Nishida, Shigeki Bamba, Osamu Inatomi, Akira Andoh   +8 more
wiley   +1 more source

Naoxintong Is Involved in the Coagulation Regulation of Warfarin Through the MAPK Pathway. [PDF]

Pharmgenomics Pers Med
Luo X, Chen L, Xu J, Li J.
europepmc   +1 more source

Establishment of a swine model of delayed bleeding after endoscopic procedure

DEN Open, Volume 5, Issue 1, April 2025.
Abstract Objectives Although delayed bleeding after endoscopic procedures has become a problem, currently, there are no appropriate animal models to validate methods for preventing it. This study aimed to establish an animal model of delayed bleeding after endoscopic procedures of the gastrointestinal tract. Methods Activated coagulation time (ACT) was
Shohei Uehara, Fumisato Sasaki, Hisashi Sahara, Akihito Tanaka, Makoto Hinokuchi, Hidehito Maeda, Shiho Arima, Shinichi Hashimoto, Shuji Kanmura, Akio Ido   +9 more
wiley   +1 more source

Pharmacodynamic Modeling of Warfarin Dosing Algorithm for Cardiovascular Patients in Indonesia: A Tailored Method to Anticoagulation Therapy. [PDF]

Drug Des Devel Ther
Putriana NA, Latarissa IR, Rusdiana T, Rostinawati T, Akbar MR.   +4 more
europepmc   +1 more source