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Exacerbation of Hereditary Warfarin Resistance by Azathioprine
A 39-year-old Afro-Caribbean man with Crohn disease with recurrent deep vein thromboses and pulmonary emboli was commenced on lifelong warfarin treatment.
William G Newman +2 more
exaly +5 more sources
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Comparative genetics of warfarin resistance
Hamostaseologie, 2014SummaryWarfarin and other 4-hydroxycoumarinbased oral anticoagulants targeting vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) are administered to humans, mice and rats with different purposes in mind – to act as pesticides in high-dosage baits for killing rodents, but also to save lives when administered in low dosages as antithrombotic ...
Johannes Oldenburg +2 more
exaly +3 more sources
Drug Intelligence & Clinical Pharmacy, 1983
Warfarin, a coumarin anticoagulant, acts by interfering with the hepatic synthesis of the vitamin-K-dependent clotting factors. It is used clinically in the treatment or prophylaxis of venous thrombosis and embolisms. Resistance to the effects of the coumarin and indanedione anticoagulants has been reported in rats and man, but its ...
R J, Holt, C O, Freytes
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Warfarin, a coumarin anticoagulant, acts by interfering with the hepatic synthesis of the vitamin-K-dependent clotting factors. It is used clinically in the treatment or prophylaxis of venous thrombosis and embolisms. Resistance to the effects of the coumarin and indanedione anticoagulants has been reported in rats and man, but its ...
R J, Holt, C O, Freytes
openaire +2 more sources
Hereditary Warfarin Resistance
Southern Medical Journal, 1994We report on a case of hereditary warfarin resistance in a 27-year-old black man. Hereditary warfarin resistance is a rare disorder transmitted as autosomal dominant. It should be suspected in patients who require high doses of warfarin, achieve high plasma warfarin levels, and have a normal plasma warfarin clearance.
F, Diab, S, Feffer
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Warfarin resistance: biochemical evaluation of a warfarin-resistant wild brown rat
Biochemical Pharmacology, 1989We investigated the in vitro characteristics of the hepatic vitamin KO reductase of these rats to elucidate the type of ...
H H, Thijssen +2 more
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Warfarin resistance due to malabsorption
Journal of Internal Medicine, 1994Abstract. A female patient developed warfarin resistance after 2 years of satisfactory therapy. Only a third of orally administered warfarin was absorbed, the clearance of warfarin was normal. The patient was also resistant for dicoumarol, while phenindione had satisfactory effect on the prothrombin time (PT).
I, Talstad, O N, Gamst
exaly +3 more sources
Malabsorption-associated warfarin resistance
American Journal of Health-System Pharmacy, 2009A case of malabsorption- associated warfarin resistance is reported.A 42-year-old, 111-kg, Caucasian man arrived at the emergency department with atypical pleuritic chest pain. The chest pain was associated with shortness of breath, diaphoresis, nausea, vomiting, and tachycardia.
Brian J, Sabol +2 more
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Warfarin Resistance Due to Sulfasalazine
Annals of Pharmacotherapy, 2000OBJECTIVE: To report a case of warfarin resistance associated with the use of sulfasalazine. CASE SUMMARY: A 37-year-old white woman on oral anticoagulant therapy with warfarin was being evaluated for complaints of joint pains.
A M, Teefy, J E, Martin, M J, Kovacs
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