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Comparative genetics of warfarin resistance
Hämostaseologie, 2014SummaryWarfarin and other 4-hydroxycoumarinbased oral anticoagulants targeting vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) are administered to humans, mice and rats with different purposes in mind – to act as pesticides in high-dosage baits for killing rodents, but also to save lives when administered in low dosages as antithrombotic ...
J, Oldenburg +4 more
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Warfarin Resistance with Nafcillin Therapy
Annals of Internal Medicine, 1984Drug-induced warfarin resistance may be mediated by the direct effect of a drug on warfarin's absorption, excretion, distribution, or metabolism. A 29-year-old man on long-term stable anticoagulation therapy with warfarin sodium developed resistance to warfarin while receiving nafcillin.
G D, Qureshi +3 more
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Warfarin Resistance Due to Sulfasalazine
Annals of Pharmacotherapy, 2000OBJECTIVE: To report a case of warfarin resistance associated with the use of sulfasalazine. CASE SUMMARY: A 37-year-old white woman on oral anticoagulant therapy with warfarin was being evaluated for complaints of joint pains. Her past medical history consisted of recurrent deep-vein thrombosis, asthma, and ulcerative colitis.
A M, Teefy, J E, Martin, M J, Kovacs
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Warfarin Resistance Associated With Parenteral Nutrition
The American Journal of the Medical Sciences, 2012Warfarin is widely used as an oral anticoagulant for the prevention and long-term treatment of venous thromboembolism and for the prevention of thromboembolic complications associated with atrial fibrillation, heart valve replacement and myocardial infarction.
Lily K, Cheung +2 more
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Hereditary Warfarin Resistance
Archives of Internal Medicine, 1985• A 57-year-old black woman required a daily dosage of 50 mg of warfarin sodium to maintain her prothrombin time in a therapeutic range. The central volume of distribution and clearance of warfarin were normal for this patient. These findings, combined with the patient's requirement for plasma warfarin levels four times greater than those usually ...
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Cardiovascular journal of Africa, 2008
Warfarin, the only available oral coumarin anticoagulant in South Africa, is widely prescribed for the prevention and management of arterial and venous thrombo-embolism. It has a narrow therapeutic index and a wide inter-individual variability in therapeutic response. Genetic polymorphism of the VKORC1 and CYP2C9 genes, as well as clinical factors such
P, Sinxadi, M, Blockman
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Warfarin, the only available oral coumarin anticoagulant in South Africa, is widely prescribed for the prevention and management of arterial and venous thrombo-embolism. It has a narrow therapeutic index and a wide inter-individual variability in therapeutic response. Genetic polymorphism of the VKORC1 and CYP2C9 genes, as well as clinical factors such
P, Sinxadi, M, Blockman
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Warfarin resistance associated with nafcillin therapy
The American Journal of Medicine, 1989A woman with a history of diabetes mellitus, peptic ulcer disease, hypothyroidism, systemic lupus erythematous, and myasthenia gravis was admitted to the hospital for an elective thymectomy. She had a past history of deep venous thrombosis and received long-term anticoagulation therapy with warfarin.
G L, Fraser, M, Miller, K, Kane
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Warfarin Resistance and Vitamin K
Annals of Internal Medicine, 1981Excerpt To the editor: Recently, cases of warfarin resistance due to unrecognized vitamin K supplementation in liquid nutrition products have been described (1, 2).
MARY LEE +2 more
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Warfarin Resistance: Diagnosis and Therapeutic Alternatives
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1996Warfarin resistance is a rare phenomenon, and most of the related literature obtained in a MEDLINE search from 1964–1995 consists of case reports. Warfarin resistance may develop as a result of noncompliance, exogenous consumption of vitamin K, and concurrent ingestion of other agents known to decrease warfarin's effects.
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Warfarin Resistance Associated with Intravenous Lipid Administration
Journal of Parenteral and Enteral Nutrition, 1987Intravenous lipids have been shown to have varying effects on coagulation parameters. A patient with short bowel syndrome and recurrent thrombotic episodes who required both intravenous lipids and anticoagulation is described. A constant infusion of a soybean oil emulsion (Intralipid) in his parenteral nutrient solution was demonstrated to interfere ...
D M, Lutomski, J E, Palascak, R H, Bower
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