Julius-Kühn-Archiv, 2011 The Westphalian resistant Norway rat strain is characterised by the possession of the Y139C variant of the vkorc1 gene, and practical resistance occurs in rat infestations at different frequencies to the anticoagulants warfarin, coumatetralyl ...
Klemann, N., Esther, A., Endepols, S.
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Missense VKOR mutants exhibit severe warfarin resistance but lack VKCFD via shifting to an aberrantly reduced state. [PDF]
Blood Adv, 2023 Li S +5 more
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[Hereditary warfarin resistance].
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2001 Warfarin is the major oral anticoagulant drug used in Norway. The effect is monitored by measuring the patient's prothrombin time expressed as international normalized ratio (INR). The dose necessary to achieve a therapeutic INR varies. A few patients require extremely high doses, and hereditary warfarin resistance has been reported.The present paper ...
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Warfarin resistance in Japanese population
Nosotchu, 2010 ワルファリンは用量に著しい個人差があり，様々な薬物，食品との相互作用以外にも個々で様々な程度の耐性が存在しているといっても過言ではない．逆にアジア人種ではワルファリンが効きやすく，出血合併症を起こしやすいという意見もある．通常ワルファリン耐性とは1日15 mg以上必要な場合と定義され，その原因はコンプライアンス不良やビタミンK過剰摂取などのよく知られた要因と，先天的および外因による肝代謝活性の差(pharmacokinetic resistance)，感受性の差(pharmacodynamic resistance)に大別される．そしてワルファリンの効果の個人差および人種差の原因が近年の遺伝子解析により判明しつつある．ワルファリンは消化管から速やかに吸収され，ほぼ100%肝臓でcytochrome ...
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Frontiers in NutritionNutraceuticals-including resveratrol (RSV), curcumin (CUR), piperine (PPR), and quercetin (QUE)-exhibit dual therapeutic and toxicological profiles, are necessitating balanced risk–benefit evaluation.
Sahand Ashrafpour +2 more
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HeliyonIntroduction: The coronavirus disease 2019 (COVID-19) pandemic has triggered a rise in the global phenomenon of self-medication. The use of medicines with unsubstantiated claims of benefit for the prevention and/or treatment of infected people has been ...
Christian R. Mejia +11 more
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Personalized therapeutics for levofloxacin: a focus on pharmacokinetic concerns
Therapeutics and Clinical Risk Management, 2014 Chu-Han Gao,1 Lu-Shan Yu,2 Su Zeng,2 Yu-Wen Huang,1 Quan Zhou11Department of Pharmacy, the Second Affiliated Hospital, School of Medicine, 2Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University,
Gao CH, Yu LS, Zeng S, Huang YW, Zhou Q
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Pharmacokinetic interactions of Hypericum perforatum L. (St John's wort) with conventional drugs: a review of clinical studies [PDF]
Research Journal of Pharmacognosy, 2017 Background and objectives: Hypericum perforatum L., commonly known as St. John’s wort (SJW) from the family Hypericaceae is a famous medicinal plant used to treat mild to moderate depression; so, it might affect the pharmacokinetics of numerous drugs ...
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Warfarin and bevacizumab suppress tumor progression in pancreatic ductal adenocarcinoma by targeting EGFR-PI3K-Akt signaling: inhibition of proliferation/migration and apoptosis induction. [PDF]
Transl Cancer ResChen J, Ju J, Wang J, Yang L.
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Complexities in pediatric tuberculosis: a case of advanced disease complicated by deep vein thrombosis and enterocutaneous fistula from Ethiopia. [PDF]
BMC Infect DisBogale A, Toma T, Baramo DD.
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