Results 51 to 60 of about 2,357,394 (215)

Dual Genotoxic and Antigenotoxic Effects of 3‐Benzoylcoumarins in Mammalian Cells

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Coumarins are phenolic compounds widely recognized for their diverse pharmacological activities and have attracted increasing attention as potential chemopreventive agents. In the present study, four known 3‐benzoylcoumarin derivatives [(1), (2), (3), and (4)] were evaluated for their cytotoxic, mutagenic, and antigenotoxic effects in Chinese ...
Leticia Helena Parreira   +7 more
wiley   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

open access: yesPhytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia   +1 more
wiley   +1 more source

Maternal and Fetal Outcomes in Pregnant Women with a Prosthetic Mechanical Heart Valve

open access: yesClinical Medicine Insights: Cardiology, 2016
Background Pregnancy is associated with several cardiocirculatory changes that can significantly impact underlying cardiac disease. These changes include an increase in cardiac output, sodium, and water retention leading to blood volume expansion, and ...
Sherif W. Ayad   +3 more
doaj   +1 more source

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit   +5 more
wiley   +1 more source

Advances in Unconventional and Sustainable Synthetic Approaches to Benzopyran Scaffolds

open access: yesThe Chemical Record, EarlyView.
This review provides a comprehensive and critical analysis of low‐impact synthetic methodologies reported in the last 8 years (2018–2026) for the construction of benzopyran‐derived scaffolds, such as coumarins, flavones, chromones, chromenes, and chromanes. The benzopyran scaffold is a versatile family of heterocycles found in a wide range of bioactive
Nathalia B. Sá   +4 more
wiley   +1 more source

Impact of PCSK9, WDR12, CDKN2A, and CXCL12 Polymorphisms in Jordanian Cardiovascular Patients on Warfarin Responsiveness and Sensitivity

open access: yesInternational Journal of General Medicine, 2021
Rasheed K Ibdah,1 Laith N AL-Eitan,2 Nasr N Alrabadi,3 Ayah Y Almasri,2 Adan H Alnaamneh,2 Rame H Khasawneh,4 Mansour A Alghamdi5,6 1Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology,
Ibdah RK   +6 more
doaj  

Addressing Long‐Tailed Drug–Drug Interactions Through Minimisation of Predictive Uncertainty and Loss Sharpness

open access: yesCAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Drug–Drug Interaction (DDI) prediction is critical for ensuring patient safety, particularly under long‐tailed distributions, where frequent (head) interactions dominate whereas rare (tail) interactions remain underrepresented. Conventional loss functions such as cross‐entropy often tend to overfit head classes while they underperform on rare ...
Chao Liu   +3 more
wiley   +1 more source

Anticoagulant Rodenticides Contribute to a Decline in an Urban Carnivore

open access: yesAnimal Conservation, EarlyView.
Anticoagulant rodenticides (ARs) have been shown to negatively affect carnivores globally and are closely tied to human activity and development. We examined drivers of annual survival in bobcats persisting on a residentially developed barrier island over 16 years.
Meghan P. Keating   +7 more
wiley   +1 more source

Warfarin Resisance and Recurrent Thrombosis in an Iranian Patient

open access: yesCase Reports in Clinical Practice, 2019
Warfarin resisance was known as subtherapeutic INR (International Normalized Ratio) in spite of normally prescribed doses of warfarin. There are few reports of warfarin resisance from Iran.
Masuod Malekzadeh, Marzieh Pazoki
doaj  

Continuous‐Flow Left Ventricular Assist Devices in Biventricular Configuration: A Systematic Review and Comparative Meta‐Analysis of HeartMate 3 and HeartWare Biventricular Assist Devices

open access: yesArtificial Organs, EarlyView.
HeartWare‐BiVAD was associated with more frequent right ventricular cannulation, whereas HM3‐BiVAD demonstrated a trend toward improved survival despite a more severe preimplant clinical profile, suggesting a potential device‐related advantage of HM3 in biventricular support.
Daler Rahimov   +10 more
wiley   +1 more source

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