Results 41 to 50 of about 64,384 (262)

Warm forming of 7075 aluminum alloys

open access: yesProcedia Engineering, 2017
Abstract The paper presents forming results of the drawpiece made of T6 temper 7075 aluminum alloy. The development of new, state-of-the-art forming methods by scientific and research centers is mainly driven by increasing demand for lightweight construction materials characterized by superior mechanical properties. As an example, new forming methods
Sławomir Polak   +7 more
openaire   +1 more source

INVESTIGATION OF THE HEATING TEMPERATURE INFLUENCE ON MECHANICAL CHARACTERISTICS AND DEFORM ABILITY OF STEEL OF TYPE 18HG AT NON-FULL HOT DEFORMATION

open access: yesЛитьë и металлургия, 2006
Steel forming technology in conditions of warm forming is a process, which is very attractive for technological practice in term of lower energy consumption, higher quality of the surfase and dimensional precision of gorged pieces.
М. Kapustova, V. Tittel
doaj  

The Influence of Heat and Holding Time on the Warm Forming of Al–Mg–Si Alloys

open access: yesJournal of Manufacturing and Materials Processing
Warm forming of heat-treatable aluminium alloys can induce significant changes in their initial heat treatment, affecting both the forming process and the final in-service properties.
Vasco Simões   +3 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Effect of temperature and strain rate fluctuation on forming limit curve of 5083 Al-Mg alloy sheet

open access: yesAdvances in Mechanical Engineering, 2022
The temperature and strain rate have significant effect on the formability of Al-Mg alloy sheet during warm forming process. Forming limit curve (FLC) is widely used for predicting sheet failure in warm forming simulation. However, the current simulation
Bo Hou   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Warm Spray Forming of Ti-6Al-4V [PDF]

open access: yesJournal of Thermal Spray Technology, 2013
Warm spray (WS) is a modification of high-velocity oxy-fuel spraying, in which the temperature of the supersonic gas flow generated by the combustion of kerosene and oxygen is controlled by diluting the combustion flame with an inert gas such as nitrogen.
Molak, R. M.   +5 more
openaire   +1 more source

Warm-forming of pre-aged Al-Zn-Mg-Cu alloy sheet

open access: yesMaterials & Design, 2020
Aluminium alloys of the 7xxx series are attracting the attention of automakers due to their high specific strength. However, widespread use of 7xxx series alloys for the production of car parts from sheet metal has so far been prevented due to their low ...
Johannes A. Österreicher   +6 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

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