Results 41 to 50 of about 13,036,972 (301)

Effect of Forming Temperature on Linear Roll Forming of 6011 Aluminum Sheets: An Analysis Based on Experimental Design

Journal of Manufacturing and Materials Processing
This study analyzed the effect of forming temperature on the roller hemming process of AA6011-T4 aluminum alloy sheets, using a 2K factorial design to also evaluate the influence of roller diameter and flange height. A total of 24 experimental tests were
Luis Andrés García Velásquez, Pablo Alberto Limon-Leyva, Ian Sosa-Tinoco, Eusebio Jiménez López, Antonio de J. Balvantin-Garcia   +4 more
doaj   +1 more source

Research on Al-alloy sheet forming formability during warm/hot sheet hydroforming based on elliptical warm bulging test

AIP Advances, 2018
An elliptical warm/hot sheet bulging test under different temperatures and pressure rates was carried out to predict Al-alloy sheet forming limit during warm/hot sheet hydroforming.
Gaoshen Cai, Chuanyu Wu, Zepu Gao, Lihui Lang, Sergei Alexandrov   +4 more
doaj   +1 more source

A Microstructure-Integrated Ductile Fracture Criterion and FE-Based Framework for Predicting Warm Formability of AA7075 Sheets

Metals
Variations in the warm formability of AA7075 sheets are primarily attributed to differences in precipitate morphology resulting from distinct thermal histories.
Wan-Ling Chen, Rong-Shean Lee
doaj   +1 more source

Effect of Process Variables on Interface Friction Characteristics in Strip Drawing of AA 5182 Alloy and Its Formability in Warm Deep Drawing

Journal of Manufacturing and Materials Processing, 2023
Warm forming is widely used to enhance the formability of aluminum alloy sheets. In warm deep drawing, the process variables significantly affect frictional characteristics at the tool–blank interface.
Archit Shrivastava, Ravi Kumar Digavalli
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Properties of B-pillar made of aluminium 7075 in warm forming process

Procedia Manufacturing, 2019
This paper presents the properties of warm forming of a B-pillar from 7075 aluminum alloy in state T6. Based on preliminary mathematical modeling, it was determined that the greatest strains and risk of aluminum cracking occur in the foot of B-pillar ...
Z. Gronostajski, S. Polak, K. Jaśkiewicz, Paweł Kaczyńskia, Matuesz Skwarski, J. Krawczyk, W. Chorzępa, K. Sliz, S. Uzar   +8 more
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source