Results 51 to 60 of about 515,316 (299)

Chandra Observations of "The Antennae" Galaxies (NGC 4038/39) [PDF]

, 2001
We report the results of a deep Chandra ACIS pointing at the merging system NGC 4038/39. We detect an extraordinarily luminous population of X-ray sources, with luminosity well above that of XRBs in M31 and the Milky Way.
A. Zezas, Amram P., G. Fabbiano, Garmire G. P., Hummel E., Read A. M., S. S. Murray, Sansom A. E., Zezas A.   +8 more
core   +2 more sources

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Effect of temperature and strain rate fluctuation on forming limit curve of 5083 Al-Mg alloy sheet

Advances in Mechanical Engineering, 2022
The temperature and strain rate have significant effect on the formability of Al-Mg alloy sheet during warm forming process. Forming limit curve (FLC) is widely used for predicting sheet failure in warm forming simulation. However, the current simulation
Bo Hou, Yong Huang, Mingming Ding, Hongji Dong   +3 more
doaj   +1 more source

Stars were born in significantly denser regions in the early Universe [PDF]

, 2014
The density of the warm ionized gas in high-redshift galaxies is known to be higher than what is typical in local galaxies on similar scales. At the same time, the mean global properties of the high- and low-redshift galaxies are quite different.
Brinchmann, Jarle, Rahmati, Alireza, Shirazi, Maryam   +2 more
core   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Importance of far-infrared mapping in a spiral galaxy: AKARI observation of M81

, 2010
The importance of the far-infrared (FIR) mapping is demonstrated for a face-on spiral galaxy, M81, by analyzing its imaging data at 65, 90, and 140 {\mu}m taken by AKARI.
Aannestad, Ai-Lei Sun, Baggett, Bendo, Braun, Buat, Cheng, Dale, Dale, Draine, Draine, Draine, Freedman, Harper, Hibi, Hirashita, Hirashita, Hirashita, Hiroyuki Hirashita, Inoue, Kawada, Kennicutt, Li, Lowe, Mathis, Mathis, Murakami, Nagata, Pilbratt, Poglitsch, Pollo, Pérez-González, Reach, Rice, Rots, Sauvage, Shibai, Shirahata, Suzuki, Suzuki, Takeuchi, Walterbos, Weingartner, Yamamura   +43 more
core   +1 more source

NRO M33 All-Disk Survey of Giant Molecular Clouds (NRO MAGiC): II. Dense Gas Formation within Giant Molecular Clouds in M33 [PDF]

, 2012
We report the results of our observations of the 12CO (J=1-0) and 12CO (J=3-2) line emission of 74 major giant molecular clouds (GMCs) within the galactocentric distance of 5.1 kpc in the Local Group galaxy M33.
Hirota, Akihiko, Kaneko, Hiroyuki, Kawabe, Ryohei, Kohno, Kotaro, Komugi, Shinya, Kuno, Nario, Miura, Rie, Muraoka, Kazuyuki, Nakanishi, Kouichiro, Onodera, Sachiko, Sawada, Tsuyoshi, Tosaki, Tomoka   +11 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source