Results 41 to 50 of about 1,672,401 (290)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Respiratory muscle specific warm-up and elite swimming performance [PDF]

, 2013
Background: Inspiratory muscle training has been shown to improve performance in elite swimmers, when used as part of routine training, but its use as a respiratory warm-up has yet to be investigated.
Gupta, Luke, Hearson, Glenn, Lindley, Martin R., Lobb, Claire, Martin, Neil, McKeever, Tricia M., Shaw, Dominick E., Sherriff, Tom, Wilson, Emma Elizabeth   +8 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The Basketball warms-ups - theoretical assumptions and practical solutions

Journal of Education, Health and Sport, 2017
Many authors emphasize the importance of warm-up. Warm-up in team games aims at enhancing the body adaptation to the physical activity and to activate physiological functions from the rest state to the active state. Warm-up brings many different benefits,
Sebastian Łubiński, Jan Kosendiak
doaj   +3 more sources

RAMP vs. Traditional Warm-Up: How Different Strategies Influence Sprint, Jump, and Change of Direction Performance?

Research in Sports Science
This study aimed to compare the acute effects of Raise, Activate, Mobilize, Potentiate and traditional warm-up protocols on performance parameters. Sprint, jump, and change of direction abilities, which are critical components of sports performance ...
Selman Kaya
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Heat Attainment and Retention in Surfers with and without a Land-Based Warm-Up and Accompanying Passive Heat Retention

Sports
Surfing is a growing, high-participation recreational and competitive activity. It is relatively unique, being performed on, in, and through water with a range of temperatures.
Christian J. Cook, Benjamin G. Serpell, Lauren J. Hanna, Aaron Fox, Phillip J. Fourie   +4 more
doaj   +1 more source

Warming up the fibres

Journal of High Energy Physics
Abstract Fibre inflationary models are constructed in type-IIB string flux compactification. These models have been shown to be in agreement with the cosmological observations under appropriate choices of parameters, which originate from their string theory construction. In the present work, we embed such models, originally studied
Dibya Chakraborty, Rudnei O. Ramos
openaire   +2 more sources

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

The Effects of Different Stretching Techniques Used in Warm-Up on the Triggering of Post-Activation Performance Enhancement in Soccer Players

Applied Sciences
The aim of this research was to investigate the effects of different stretching techniques used during warm-up exercises prior to post-activation performance enhancement (PAPE) on the explosive lower extremity strength performance of soccer players. This
Kemal Kurak, İsmail İlbak, Stefan Stojanović, Ramazan Bayer, Tijana Purenović-Ivanović, Tomasz Pałka, Tadeusz Ambroży, Krzysztof Kasicki, Wojciech Czarny, Łukasz Rydzik   +9 more
doaj   +1 more source