Results 41 to 50 of about 593,375 (206)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Alcohol warning labels: unlikely to affect alcohol‐related beliefs and behaviours in adolescents

Australian and New Zealand Journal of Public Health, 2012
Objective: In Australia, many health researchers and policy makers are advocating for mandated warning labels on alcoholic beverages. Alcohol‐related harms are of particular concern among adolescents.
Kirsty E. Scholes‐Balog, Jessica A. Heerde, Sheryl A. Hemphill   +2 more
doaj   +1 more source

Development of the Chilean front-of-package food warning label

BMC Public Health, 2019
Background Front-of package (FoP) nutrition labels are an option to guide consumer’s decision at the point of food purchase. Chile was the first country worldwide to implement a FoP warning label and thereafter several countries have followed this model.
Marcela Reyes, María Luisa Garmendia, Sonia Olivares, Claudio Aqueveque, Isabel Zacarías, Camila Corvalán   +5 more
doaj   +1 more source

National Hydrological Warning Council - flood warning systems 101

, 2020
2013 Flood Risk Management Silver Jackets Webinar Week Session H1 August 23, 2013 3:00-4:30 EDT National Hydrological Warning Council Flood Warning Systems 101PRESENTERS August 23, 2013 Silver Jackets – Flood Warning Webinar Page 2AGENDA August 23, 2013 ...
National Hydrologic Warning Council; Harris County Flood Control District; Urban Drainage and Flood Control District (Colo.);
core  

Multi-label classification using ensembles of pruned sets [PDF]

, 2008
This paper presents a Pruned Sets method (PS) for multi-label classification. It is centred on the concept of treating sets of labels as single labels. This allows the classification process to inherently take into account correlations between labels. By
Pfahringer, Bernhard, Bernhard Pfahringer, Geoff Holmes, Holmes, Geoffrey, Jesse Read, Read, Jesse   +5 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

People adhere to content warning labels even when they are wrong due to ecologically rational adaptations

Scientific Reports
In this paper, we build on the theory of ecologically rational heuristics to demonstrate the effect of erroneously placed warning labels on news headlines.
Benjamin D. Horne, Dorit Nevo
doaj   +1 more source

Compliance With the US Food and Drug Administration’s Guidelines for Health Warning Labels and Engagement in Little Cigar and Cigarillo Content: Computer Vision Analysis of Instagram Posts

JMIR Infodemiology, 2023
BackgroundHealth warnings in tobacco advertisements provide health information while also increasing the perceived risks of tobacco use.
Jiaxi Wu, Juan Manuel Origgi, Lynsie R Ranker, Aruni Bhatnagar, Rose Marie Robertson, Ziming Xuan, Derry Wijaya, Traci Hong, Jessica L Fetterman   +8 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source