Results 51 to 60 of about 39,109 (309)

Sex‐specific activation of SK current by isoproterenol facilitates action potential triangulation and arrhythmogenesis in rabbit ventricles [PDF]

, 2018
Sex has a large influence on cardiac electrophysiological properties. Whether sex differences exist in apamin‐sensitive small conductance Ca2+‐activated K+ (SK) current (IKAS) remains unknown.
Chen, Mu, Chen, Peng-Sheng, Chen, Zhenhui, Everett, Thomas H., IV, Guo, Shuai, Lin, Shien-Fong, Rubart-von der Lohe, Michael, Wang, Zhuo, Weiss, James N., Xu, Dong-Zhu, Yin, Dechun   +10 more
core   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Aerosol generation with various approaches to oxygenation in healthy volunteers in the emergency department

Journal of the American College of Emergency Physicians Open, 2021
Objectives Health care workers experience an uncertain risk of aerosol exposure during patient oxygenation. To improve our understanding of these risks, we sought to measure aerosol production during various approaches to oxygenation in healthy ...
Emily Pearce, Matthew J. Campen, Justin T. Baca, John P. Blewett, Jon Femling, David T. Hanson, Erik Kraai, Pavan Muttil, Blair Wolf, Michael Lauria, Darren Braude   +10 more
doaj   +1 more source

Cold adaptation and replicable microbial community development during long-term low temperature anaerobic digestion treatment of synthetic sewage [PDF]

, 2018
The development and, activity of a cold-adapting microbial community was monitored during low temperature anaerobic digestion (LtAD) treatment of wastewater.
Cysneiros, D., Hughes, D., Ijaz, U.Z., Keating, C., Mahony, T., O‘Flaherty, V., Smith, C.J.   +6 more
core   +2 more sources

Tailored Organogel Systems for Optimized Pesticide Delivery: Mechanistic Insights and Agricultural Applications

Advanced Science, EarlyView.
Utilizing molecular engineering for network design, three pesticide‐loaded organogels (PLOs) carriers exhibiting varying degrees of flexibility were prepared. The mechanical properties of these carriers, tunable via their network molecular structures, enhance their structural adaptability and retention stability at biological interfaces, thereby ...
Yue Wang, SiYu Xv, Chao Wu, Nan Li, GuoPeng Teng, XuePing Huang, Jian Luo   +6 more
wiley   +1 more source

Velocity vector control system augmented with direct lift control [PDF]

, 1981
A pilot-controlled stability control system that employs direct lift control (spoiler control) with elevator control to control the flight path angle of an aircraft is described.
Kelly, W. W., Tisdale, H. F., Sr.
core   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Self‐Adaptive Allantoin@ZIF8 Nanocomposite Hydrogel with Resveratrol Synergy for MRSA‐Infected Wound Regeneration

Advanced Science, EarlyView.
Based on allantoin‐loaded ZIF8 nanoparticles (Alla@ZIF8) and methacrylated quaternary ammonium carboxymethyl chitosan/resveratrol composite hydrogels (RMQCC), an adaptive multifunctional hydrogel system (Alla@ZIF8‐Gel) was constructed and confirmed to induce the healing of MRSA‐infected wounds via suppressing bacterial proliferation, alleviating ...
Yongjie Zhu, Dun Liu, Mengran Zhao, Xinyi Jian, Enuo Peng, Xingping Zhao, Zezhang Zhu, Bolin Tang, Benlong Shi   +8 more
wiley   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source