Results 61 to 70 of about 18,795 (241)

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

British Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert, Carl M. J. Kirkpatrick, Rory Marriott, Siladitya Ray Chaudhuri, David Polidori, Bart Remmerie, Michelle P. McIntosh   +6 more
wiley   +1 more source

Improving Active Resonance Damping and Unbalanced Voltage Mitigation Based on Combined DDSRF and Washout Filter in Islanded Microgrids

IEEE Access
The existence of imbalanced single- and two-phase loads, coupled with short-circuit faults, contributes to voltage imbalance. It is inevitable to use LCL filters to remove harmonics caused by converter switching.
Ehsan Akbari, Mahan Fakhrooeian, Mostafa Jabari, Hamidreza Banazadeh, Monireh Ahmadi, S. M. Muyeen   +5 more
doaj   +1 more source

Active surveillance of drug safety in healthcare data: Sequential monitoring of bacterial and serious urinary tract infection risk in sodium‐glucose cotransporter 2 inhibitor users

British Journal of Clinical Pharmacology, EarlyView.
Abstract Introduction Active surveillance of adverse events using healthcare data is emerging as complementary to the monitoring of spontaneous reports and stand‐alone pharmacoepidemiologic studies. The risk of urinary tract infections (UTIs) was listed as a special warning for sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) when marketed in Europe
Haoxin Le, Dilsad Simay Peker, Lukas Frederic Westphal, Nikolai Brun, Christine Erikstrup Hallgreen, Morten Andersen   +5 more
wiley   +1 more source

Evaluation of a pantoprazole and 4‐desmethylpantoprazole‐sulfate metabolic ratio as a novel CYP2C19 phenotyping method

British Journal of Clinical Pharmacology, EarlyView.
Aims CYP2C19 is one of the most important pharmacogenes, and its activity is highly variable due to factors such as genetics or drug–drug interactions. Due to the lack of an appropriate endogenous CYP2C19 biomarker, surrogate methods to assess its activity are warranted.
Julian Peter Müller, Vladimir N. Belov, Sabrina Yamoune, Bob Miller, Mohammed Hasoumi, Jolanta Tupiec, Thea Laurentius, L. Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

Análisis de un Proceso de Tratamiento de Efluentes para Producción de Metano

Revista Iberoamericana de Automática e Informática Industrial RIAI, 2014
Resumen: En este trabajo se presenta un análisis dinámico de un reactor anaeróbico a escala laboratorio, el cual es empleado para la obtención de biogás a partir del tratamiento de aguas residuales.
Salvador Carlos-Hernández, Edgar N. Sanchez, Jean-François Béteau, Lordes Díaz Jiménez   +3 more
doaj   +1 more source

Drug‐coated balloons: From conventional designs to next‐generation innovations in vascular therapy

BMEMat, EarlyView.
This review traces the evolution of drug‐coated balloons (DCBs) from conventional designs to next‐generation platforms. We highlight innovations in balloon engineering, coating technologies, and therapeutic agents that enhance localized drug delivery while addressing challenges in efficiency, safety, and biocompatibility for vascular and emerging non ...
Lu Zhang, Jiawei Cui, Jin Wang, Manfred F. Maitz, Rifang Luo, Yunbing Wang   +5 more
wiley   +1 more source

Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release

Chemistry – A European Journal, EarlyView.
Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka, Marek Chovanec, Rastislav Dzijak, Michal Rahm, Jachym Hrusak, Paul E. Reyes‐Gutierrez, Milan Vrabel   +6 more
wiley   +1 more source

Assessment of the pharmacological effects of alprazolam on electroencephalography using connectivity indexes not affected by volume conduction

Frontiers in Systems Neuroscience, 2015
Introduction Electroencephalographic analysis techniques have become a very useful tool to assess brain activity and interactions between cerebral regions, that is, the so-called cerebral connectivity analysis.
Joan Francesc Alonso, Joan Francesc Alonso, Joan Francesc Alonso, Jordi Riba   +3 more
doaj   +1 more source

Isoform Specificity of a Compound Targeting Actin Filaments Containing Tropomyosin Tpm1.8/1.9

Cytoskeleton, EarlyView.
ABSTRACT The unbranched actin filaments in mammalian cells are usually composed of co‐polymers of a specific tropomyosin isoform with actin. Genetic manipulation has revealed that the tropomyosins largely define the functional properties of actin filaments in an isoform‐specific, non‐redundant manner.
Jeff Hook, Edna C. Hardeman, Peter W. Gunning   +2 more
wiley   +1 more source

PLL-Current Controller Stabilizer for Weak Grid-Connected Mixed-Domain Controlled Converters

IEEE Access
Instability issues arising from the interaction of Phase-Locked Loops (PLLs) and weak grids have become relevant research topics due to the increasing penetration of inverter-based resources in distribution systems.
Andre G. P. Alves, Cleiton M. Freitas, Oscar C. Zevallos, Lais F. Crispino, Marcello S. Neves, Luis G. B. Rolim   +5 more
doaj   +1 more source