Results 51 to 60 of about 623,412 (262)

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Aerosol generation with various approaches to oxygenation in healthy volunteers in the emergency department

Journal of the American College of Emergency Physicians Open, 2021
Objectives Health care workers experience an uncertain risk of aerosol exposure during patient oxygenation. To improve our understanding of these risks, we sought to measure aerosol production during various approaches to oxygenation in healthy ...
Emily Pearce, Matthew J. Campen, Justin T. Baca, John P. Blewett, Jon Femling, David T. Hanson, Erik Kraai, Pavan Muttil, Blair Wolf, Michael Lauria, Darren Braude   +10 more
doaj   +1 more source

An optimal washout filter for motion platform using neural network and fuzzy logic

, 2023
An optimal washout filter for motion platform using neural network and fuzzy ...
M R C Qazani (13309968), Houshyar Asadi (13073715), Shady Mohamed (13094061), Chee Peng Lim (13063809), Saeid Nahavandi (13086675)   +4 more
core  

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Advanced Science, EarlyView.
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin, Kang Duan, Rui Wan, Tao Jiang, Jinzhe Wei, Miao Sun, Mariia A. Skryl'nikova, Maxim A. Gureev, Zhi‐Min Zhang, Zhang Zhang, Ke Ding, Nan Ma, Tongzheng Liu, Yi Tan, Zhengqiu Li   +14 more
wiley   +1 more source

Artificial Intelligence‐Empowered Single‐Cell Phenotyping for Rapid, Automated Pathogen Diagnostics

Advanced Science, EarlyView.
This work presents an integrated diagnostic platform that combines microfluidic single‐cell bacterial detection with artificial intelligence‐driven analysis for rapid antimicrobial susceptibility testing. Single‐cell phenotyping enables assessment of antibiotic response in only a few cell replication cycles, while AI analysis supports precise bacterial
Sabita Khadka, Bushra Raahat, Spyros Tragoudas, Hui Li   +3 more
wiley   +1 more source

Hyper‐Intense Tumor Peripheral Accumulation of Antibody‐Conjugated Iron Oxide Nanoparticles can Enable Breast Cancer Detection by Magnetic Particle Imaging

Advanced Science, EarlyView.
Tumor‐associated inflammation retains antibody‐targeted or non‐specific antibody conjugated nanoparticles within the tumor microenvironment. Magnetic Particle Imaging (MPI) enables non‐invasive detection and differentiation of tumors from other organs, owing to higher nanoparticle retention by inflammatory cells in the tumor periphery.
Preethi Korangath, Hayden Carlton, Theresa Wong, Sean Healy, Toby Sanders, Mason Song, Patrick W. Goodwill, Cordula Grüttner, Kathleen Gabrielson, Robert Ivkov   +9 more
wiley   +1 more source

On the Design of Oversampled Filter Banks for Channel Coding [PDF]

, 2004
Oversampled filter banks have been considered for channel coding, because they introduce redundancy into the subband representation of signals and permit more freedom in their design than critically sampled structures.
Weiss, S, Weiss, S.
core   +2 more sources

Washout filter based control for the Hodgkin-Huxley nerve cell dynamics

, 2010
In this work we present a washout filler based control approach for stabilizing the oscillations in Hodgkin-Huxley type neurons. The oscillations occur due to the bifurcations that arise from the potassium and sodium channel conductance deviations.
Doruk, Resat Oezguer
core   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Enhanced Three-Phase Inverter Control: Robust Sliding Mode Control with Washout Filter for Low Harmonics

Energies
This paper presents a robust control strategy for three-phase inverters that combines Sliding Mode Control with a Washout Filter (SMC-w) to achieve low harmonic distortion and high dynamic stability. The proposed approach addresses the critical challenge
Fredy E. Hoyos, John E. Candelo-Becerra, Alejandro Rincón   +2 more
doaj   +1 more source