Results 81 to 90 of about 39,109 (309)

Safety, Pharmacokinetics, and Dose Recommendations for Nirmatrelvir/Ritonavir in Individuals with Mild to Moderate COVID‐19 and Severe Renal Impairment

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Patients with severe renal impairment and COVID‐19 are at high risk for severe disease and death. Nirmatrelvir/ritonavir, an antiviral therapy for COVID‐19, is eliminated by renal excretion and can accumulate in patients with severe renal impairment.
Jacqueline Gerhart   +7 more
wiley   +1 more source

Evaluation of a linear washout for simulator motion cue presentation during landing approach [PDF]

open access: yes
The comparison of a fixed-base versus a five-degree-of-freedom motion base simulation of a 737 conventional take-off and landing (CTOL) aircraft performing instrument landing system (ILS) landing approaches was used to evaluate a linear motion washout ...
Martin, D. J., Jr., Parrish, R. V.
core   +1 more source

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer   +24 more
wiley   +1 more source

Assessment of the pharmacological effects of alprazolam on electroencephalography using connectivity indexes not affected by volume conduction

open access: yesFrontiers in Systems Neuroscience, 2015
Introduction Electroencephalographic analysis techniques have become a very useful tool to assess brain activity and interactions between cerebral regions, that is, the so-called cerebral connectivity analysis.
Joan Francesc Alonso   +3 more
doaj   +1 more source

A method motion simulator design based on modeling characteristics of the human operator [PDF]

open access: yes, 1978
A design criteria is obtained to compare two simulators and evaluate their equivalence or credibility. In the subsequent analysis the comparison of two simulators can be considered as the same problem as the comparison of a real world situation and a ...
Junker, A. M., Repperger, D. W.
core   +1 more source

Implementation of guideline‐recommended medical therapy for patients with heart failure in Europe

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 790-798, April 2025.
Abstract Physicians' adherence to guideline‐recommended heart failure (HF) treatment remains suboptimal, especially regarding the target doses. In particular, there is evidence that non‐cardiologists are less compliant with HF guideline recommendations. This is likely to have a detrimental impact on patients' survival, readmissions and quality of life.
Maurizio Volterrani   +11 more
wiley   +1 more source

Modulation of a sustained calcium current by intracellular pH in horizontal cells of fish retina. [PDF]

open access: yes, 1993
A sustained high voltage-activated (HVA), nifedipine- and cadmium-sensitive calcium current and a sustained calcium action potential (AP) were recorded from horizontal cells isolated from catfish retina.
Copenhagen, DR, Dixon, DB, Takahashi, K
core  

Prediction and Simulator Verification of Roll/Lateral Adverse Aeroservoelastic Rotorcraft–Pilot Couplings [PDF]

open access: yes, 2015
The involuntary interaction of a pilot with an aircraft can be described as pilot-assisted oscillations. Such phenomena are usually only addressed late in the design process when they manifest themselves during ground/flight testing. Methods to be able
Battipede M.   +14 more
core   +2 more sources

Biomass‐derived hydrochars as eco‐friendly adsorbents for wastewater treatment applications

open access: yesEnvironmental Progress &Sustainable Energy, EarlyView.
Abstract Emerging organic pollutants (EOPs), such as diethyl phthalate (DEP), bisphenol A (BPA), and methylene blue (MB), are only partially removed in conventional wastewater treatment plants. This study assesses hydrochars produced by hydrothermal carbonization (HTC) of spruce bark (SB), vine shoots (VSs), and wheat straw (WSs) for removing three ...
Emanuel Gheorghita Armanu   +6 more
wiley   +1 more source

Computed Responses of Several Aircraft to Atmospheric Turbulence and Discrete Wind Shears [PDF]

open access: yes
The computed RMS and peak responses due to atmospheric turbulence and discrete wind shears, respectively, are presented for several aircraft in different flight conditions.
Heffley, R. K.   +2 more
core   +1 more source

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