Results 101 to 110 of about 8,838,195 (361)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Concepts d'efficience et de productivité de l'eau (synthèse bibliographique)

open access: yesBiotechnologie, Agronomie, Société et Environnement, 2014
Water efficiency and productivity concepts. A review. Water efficiency and productivity indicators are used in many scientific disciplines, usually to account for water losses that occur during its use, or products generated per unit of water consumed ...
Kambou, D.   +3 more
doaj  

Improving Intrinsic Water-Use Efficiency and Crop Yield

open access: yesCrop Science, 2002
Greater yield per unit rainfall is one of the most important challenges in dryland agriculture. Improving intrinsic water‐use efficiency (WT), the ratio of CO2 assimilation rate to transpiration rate at the stomata, may be one means of achieving this goal.
Condon, Anthony G   +3 more
openaire   +2 more sources

Productive Efficiency in Water Usage: An Analysis of Differences among Farm Types and Sizes in Georgia [PDF]

open access: yes
In Georgia, the price of irrigation water is equal to the cost of extraction, including pumping and diversion, storage, treatment, and delivery costs. These water-pricing conditions are repeated in locales around the world.
Moore, Rebecca, Price, Joseph
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Critical review on improving irrigation water use efficiency: Advances, challenges, and opportunities in the Ethiopia context

open access: yes, 2020
The demand for fresh water is constantly increasing among all water users. Irrigation in Ethiopia consumes a large amount of water extracted from various sources.
Daniel G. Eshete   +2 more
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Water use efficiency of tomatoes - in greenhouses and hydroponics [PDF]

open access: yes
Massive amounts of water are required for the production of our food, varying from several cubic metres per kilogram of beef to as low as 4 litres per kilogram for tomatoes grown in high-tech glasshouses.
Nederhoff, E.M., Stanghellini, C.
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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