Results 61 to 70 of about 18,116,413 (332)

Melatonin modulates the Notch1 signaling pathway and Sirt3 in the hippocampus of hypoxic-ischemic neonatal rats

Scientific Reports
The Notch1 signaling pathway plays a crucial role in the development of the central nervous system, governing pivotal functional activities in the brain, such as neurogenesis.
Atefeh Mohammadi, Water Balduini, Silvia Carloni   +2 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Key components of developing midwifery preceptors: a pathway to strengthen midwifery education and care in low resource settings

BMC Global and Public Health
Strengthening midwifery education and the quality of midwifery care is one of the most impactful interventions to address maternal and newborn morbidity and mortality.
Brittney J. van de Water, Julie Mann
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Influence of temperature on the volumetric properties of ethanol + water + 1–pentanol [PDF]

Journal of the Serbian Chemical Society, 2004
Knowledge of physical properties and phase equilibria is necessary for the design and optimization of the equipment for the production of distilled alcoholic beverages.
M. IGLESIAS, C. GONZALEZ, J. M. GOENAGA, J. M. RESA   +3 more
doaj  

Potential of condensate as a water source from air conditioning systems: A thermodynamic analysis [PDF]

Journal of Applied Research in Water and Wastewater
A considerable amount of water condensate produced through the cooling coils of air conditioning systems is usually directed to municipal sewage systems and wasted along with the energy it contains.
Koorosh Goudarzi
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Assessing Parents' Perception of Children's Risk for Recreational Water Illnesses

Emerging Infectious Diseases, 2005
Understanding people's risk perceptions and motivations to adopt preventive behavior is important in preventing the spread of recreational water illnesses (RWI) and other emerging infectious diseases. We developed a comprehensive scale measuring parents'
Jacquelyn McClain, Jay M. Bernhardt, Michael J. Beach   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Reassessing the projections of the World Water Development Report

npj Clean Water, 2019
The 2018 edition of the United Nations World Water Development Report stated that nearly 6 billion peoples will suffer from clean water scarcity by 2050.
A. Boretti, L. Rosa
semanticscholar   +1 more source