Results 111 to 120 of about 5,241,192 (308)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Vacuum drying of red currant (Ribes rubrum L.): Physical and chemical properties and kinetic modeling [PDF]

Food and Feed Research, 2019
Red currants (Ribes rubrum L.) were dried by vacuum drying on different drying temperatures (30, 40, 50, 60 and 70 °C) at constant pressure (20 mbar).
Vakula Anita S., Drašković-Berger Mirna V., Daničić Tatjana N., Tepić-Horecki Aleksandra N., Pavlić Branimir M., Jokanović Marija R., Šumić Zdravko M.   +6 more
doaj  

Solid-state fermentation of paper sludge to obtain spores of the fungus Trichoderma asperellum

The EuroBiotech Journal, 2019
Paper production generates large quantities of a solid waste known as papermaking sludge (PS), which needs to be handled properly for final disposal.
Dorta-Vásquez Rosa, Valbuena Oscar, Pavone-Maniscalco Domenico   +2 more
doaj   +1 more source

Comparação de modelos matemáticos para descrição das curvas de dessorção de sementes de milho-doce Comparison of mathematical models for description of desorption curves of sweet corn seeds

Pesquisa Agropecuária Brasileira, 2001
Este trabalho teve como objetivo determinar as curvas de dessorção das sementes de milho-doce (Zea mays L.), cultivares Superdoce e Doce Cristal, e ajustar diferentes modelos matemáticos aos dados obtidos. As sementes das duas cultivares foram submetidas
Eduardo Fontes Araújo, Paulo César Corrêa, Roberto Ferreira da Silva   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Water sorption properties of Dutch type semi-hard cheese edge in the range of common storing temperatures

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2011
Moisture sorption isotherms of Dutch type semi-hard cheese edge in the temperature range of 10–25 ºC and water activity (Aw) from 0.11 to 0.98 were determined using manometric method. The sorption curves had a sigmoid shape.
Maria Carolina Soares Pereira, Jiří Štencl, Bohumíra Janštová, Václav Vlášek   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Uso de cal virgem para o controle de Salmonella spp. e Clostridium spp. em camas de aviário Quicklime for controlling Salmonella spp. and Clostridium spp in litter from floor pens of broilers

Ciência Rural, 2009
O objetivo deste trabalho foi avaliar a eficácia do uso de cal virgem (CaO) para a redução de Salmonella spp. e Clostridium spp. em cama de aviário. Foram aplicados quatro tratamentos: T1- sem adição de cal virgem (controle), T2- aplicação de cal virgem ...
Marcos Antonio Dai Pra, Érico Kunde Corrêa, Victor Fernando Roll, Eduardo Gonçalves Xavier, Débora Cristina Nichelle Lopes, Fernanda Fernandes Lourenço, Jerri Teixeira Zanusso, Aline Piccini Roll   +7 more
doaj  

Thirstin's Groundwater Movement Activity [PDF]

This activity demonstrates how different sizes of rock materials that make up an aquifer affect water movement. Students discover that ground water must be able to move through underground materials at rates fast enough to supply useful amounts of water ...

core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source