Results 131 to 140 of about 5,241,192 (308)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

A Study on Ajuga bracteosa wall ex. Benth for analgesic activity [PDF]

open access: yes, 2011
Ethnopharmacological relevance: Ajuga bracteosa wall ex. Benth (Labiatae) is traditionally used medicine in the treatment of malaria and gout. The plant is substitute of cinchona. Its allied species Ajuga Parviflora is also found sporadically.
Akriti Pal , RS Pawar, Int J Cur Bio Med Sci.
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Measurement of the thorium-228 activity in solutions cavitated by ultrasonic sound

open access: yes, 2009
We show that cavitation of a solution of thorium-228 in water does not induce its transformation at a faster rate than the natural radioactive decay. We measured the activity of a thorium-228 solution in water before, and after, it was subjected to a ...
Andersen   +9 more
core   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

open access: yesMolecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Water quality evaluation in Mediterranean Lagoons using the Multimetric Phytoplankton Index (MPI): study cases from Sardinia [PDF]

open access: yes, 2013
1 - Water quality in four Sardinian lagoons (western Mediterranean Sea) was assessed using the Multimetric Phytoplankton Index (MPI), which is consistent with the EU Water Framework Directive.
Bazzoni, Anna Maria   +6 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

BBS/BBF ENCAPSULATED MICROORGANISMS TECHNOLOGY FOR SOLID INOCULATION, THE NEXT STEP TO NOT USE WATER IN BIOLEACHING PROCESSES WITH HIGH PERFORMANCE [PDF]

open access: yes, 2018
Industrial hydrometallurgical processes using copper oxides and mixed oxide/sulfide exhibit high concentrations of several ions in their raffinates that hinder the treatment of copper ores with microorganisms because they are strongly affected by ...
Martinez, Patricio, Piña, Patricia
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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