Results 121 to 130 of about 5,241,192 (308)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Water Activity In Culinary Production

open access: yesCompetitiveness and Innovation in the Knowledge Economy, 2023
Water activity is a fundamental property of aqueous solutions, and by definition is the ratio of the vapor pressure of the water in the substrate to that of pure water at the same temperature. The concept of aw has been very useful in food preservation and on that basis many processes could be successfully adapted and new products designed.
Valentina Calmâș   +2 more
openaire   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Temperature effects on Florida applesnail activity: implications for snail kite foraging success and distribution [PDF]

open access: yes, 2002
The endangered Florida snail kite (Rostrhamlls sociaiJilis) feeds exclusively on applesnails (Pomacea pailiclosa), yet we lack direct observations that link applesnail behavior to snail kite foraging success.
Stevens, Amanda J.
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Pathogenesis of sudden death following water immersion (immersion syndrome) [PDF]

open access: yes
Sympathetic activity under cold stress is investigated. Predominantly vagal cardio-depressive reflexes are discussed besides currently known mechanisms of sudden death after water immersion. Pronounced circulatory centralization in diving animals as well
Buhring, M., Spies, H. F.
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Methods to Measure Water Activity

open access: yesJournal of Food Protection, 1983
Various methods and principles for measurement of water activity are reviewed. Where data are available on performance of the methods they, too, are included along with disadvantages and advantages of the various procedures.
openaire   +2 more sources

On drift and diel vertical migration of bottom invertebrates of the Amur. [Translation from: Zoologicheskie Zhurnal 42 1601-1612, 1963.] [PDF]

open access: yes, 1963
Planktobenthos was sampled in 1957-58 in the river Amur. A determination of the kind of organisms drifting in the mass of water of the Amur was carried out.
Klyuchareva, O.A.
core  

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