Results 61 to 70 of about 1,276,993 (309)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
, 2013 Ageing drinking water, stormwater and sewer pipe networks imply an increased degree of rehabilitation. The need for rehabilitation can be predicted using lifetime distribution functions together with current network age and material distribution.
Malm, A. +11 more
core +1 more source
Bronze Age Imagery - Through Water and Fire
Current Swedish Archaeology, 2003 The article focuses on representations or indications of water and fire in the late Bronze Age imagery, primarily on one figurative theme that occurs in rock art and that composes the single and dominant motif on hanging-vessels.
Åsa Fredell
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
On the distribution of water age along hydrological pathways with transient flow
, 2013 Water age is a transient spatially distributed measure of how long water molecules are present in a hydrological system since their origin, of relevance for a variety of applications.
Soltani, Safeyeh Sofie, +1 more
core +1 more source
Survey of fungal flora in the water of old and new distribution System in Aradan city [PDF]
Journal of Advances in Environmental Health Research, 2016 One of the great concerns of potable water consumers regarding its quality is the pollution of potable water with pathogenic microorganisms. Fungi in drinking water are responsible for changing the taste and odor of water.
Mahdi Toosi +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Reservoir water intake pump house location optimization on water age
MATEC Web of Conferences, 2018 Reservoir circulating currents and water age is considered to optimize the intake pump house locations. Since the air temperature, water depth and nitrogen and phosphor input is hard to control, to optimize the water age and cycling currents of reservoir
Yang Jinyan +3 more
doaj +1 more source