Results 81 to 90 of about 1,276,993 (309)

Investigating Mountain Watershed Headwater‐To‐Groundwater Connections, Water Sources, and Storage Selection Behavior With Dynamic‐Flux Particle Tracking

Journal of Advances in Modeling Earth Systems
Climate change will impact mountain watershed streamflow both directly—with changing precipitation amounts and variability—and indirectly—through temperature shifts altering snowpack, melt, and evapotranspiration.
P. James Dennedy‐Frank, Ate Visser, Fadji Z. Maina, Erica R. Siirila‐Woodburn   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Water Supply and Water Management in the Metal Ages

<p><em>Water Supply and Water Management in the Metal Ages</em> gathers papers originally presented at the Metal Ages 2022 colloquium, hosted by the Archaeology Department of Bilkent University, Ankara and bringing together the UISPP’s Scientific Commissions ‘Metal Ages in Europe and the Mediterranean’ and ‘Archaeometry of Prehistoric
openaire   +4 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Gendered implications of COVID-19 on wastewater reuse agri-food value chains in Egypt: Current context and practical recommendations [PDF]

, 2023
The colonial legacy of irrigated agriculture in Egypt continues to reinforce food security and poverty. Marginalized tenant farmers along the tail end of Drain 7 in Kafr El Sheikh face challenges of polluted, unreliable irrigation water, low crop ...
International Water Management Institute
core  

Real‐Time Optimal Operation of Water Systems Under Demand Uncertainty and Maximum Water Age Constraints

Water Resources Research
The inherent uncertainty in water demand poses significant challenges to water distribution systems' (WDSs) efficiency and quality. This study introduces a model predictive control framework tailored for real‐time optimal operation of WDSs under ...
Elad Salomons, Hao Cao, Kristina Korder, Avi Ostfeld, Pu Li   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Employing Tank Constraints to Present Total Cost and Water Age Trade-Offs in Optimal Operation of Water Distribution Systems

Water distribution systems (WDSs) are massive infrastructure systems designed to supply water from sources to consumers. The optimal operation problem of WDSs is the problem of determining pump and tank operation to meet the consumers’ demands with
Avi Ostfeld, Tomer Shmaya
core   +1 more source

Water Age Responses to Weather Conditions in a Hyper-Eutrophic Channel Reservoir in Southern China

, 2016
Channel reservoirs have the characteristics of both rivers and lakes, in which hydrodynamic conditions and the factors affecting the eutrophication process are complex and highly affected by weather conditions.
Kumud Acharya, Wei Du, Baozhu Pan, Chao Wang, Robert Bofah Buoh, Peifang Wang, Lei Hua, Jingyu Wang, Yiping Li, Ying Wang, Li Chen, Mercy Jepkirui, Yong Jiang   +12 more
core   +1 more source

Influence of Hydraulic Model Complexity on Results of Water Age and Quality Simulation in Municipal Water Supply Systems

, 2022
The age of water in the municipal water supply system is one of the main factors influencing water quality. To create a good quality hydraulic model, one must achieve a high level of calibration accuracy with real life measurement data.
Izabela Bartkowska, Łukasz Wysocki, Wojciech Kruszyński, Anna Krysztopik, Artur Zajkowski   +4 more
core   +1 more source