Results 131 to 140 of about 1,677,787 (316)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Groundwater Availability at Congerville, Illinois (Woodford County) [PDF]
, 2009 This project is an outgrowth of the Public Service Program of the Center for Groundwater Science (CGS) at the Illinois State Water Survey. For over 50 years, the CGS has provided groundwater information to any requesting individual, commercial facility ...
Midwest Technology Assistance Center
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Groundwater Availability at Leonore (LaSalle County) [PDF]
, 2009 This project is an outgrowth of the Public Service Program of the Center for Groundwater Science (CGS) at the Illinois State Water Survey. For over 50 years, the CGS has provided groundwater information to any requesting individual, commercial facility ...
Midwest Technology Assistance Center
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Groundwater Availability at Perry, Illinois (Pike County) [PDF]
, 2009 This project is an outgrowth of the Public Service Program of the Center for Groundwater Science (CGS) at the Illinois State Water Survey. For over 50 years, the CGS has provided groundwater information to any requesting individual, commercial facility ...
Midwest Technology Assistance Center
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Groundwater Availability at Witt, Illinois (Montgomery County) [PDF]
, 2008 This project is an outgrowth of the Public Service Program of the Center for Groundwater Science (CGS) at the Illinois State Water Survey. For over 50 years, the CGS has provided groundwater information to any
Midwest Technology Assistance Center
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Groundwater Availability at Harristown, Illinois (Macon County) [PDF]
, 2009 This project is an outgrowth of the Public Service Program of the Center for Groundwater Science (CGS) at the Illinois State Water Survey. For over 50 years, the CGS has provided groundwater information to any requesting individual, commercial facility ...
Midwest Technology Assistance Center
core