Results 141 to 150 of about 1,677,787 (316)
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Groundwater Availability at Colchester, Illinois (McDonough County) [PDF]
, 2009 This project is an outgrowth of the Public Service Program of the Center for Groundwater Science (CGS) at the Illinois State Water Survey. For over 50 years, the CGS has provided groundwater information to any requesting individual, commercial facility ...
Midwest Technology Assistance Center
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Groundwater Availability at Richmond, Illinois (McHenry County) [PDF]
, 2009 This project is an outgrowth of the Public Service Program of the Center for Groundwater Science (CGS) at the Illinois State Water Survey. For over 50 years, the CGS has provided groundwater information to any requesting individual, commercial facility ...
Midwest Technology Assistance Center
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Groundwater Availability at Versailles, Illinois (Brown County) [PDF]
, 2009 This project is an outgrowth of the Public Service Program of the Center for Groundwater Science (CGS) at the Illinois State Water Survey. For over 50 years, the CGS has provided groundwater information to any requesting individual, commercial facility ...
Midwest Technology Assistance Center
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Groundwater Availability at Greenup, Illinois (Cumberland County) [PDF]
, 2009 This project is an outgrowth of the Public Service Program of the Center for Groundwater Science (CGS) at the Illinois State Water Survey. For over 50 years, the CGS has provided groundwater information to any requesting individual, commercial facility ...
Midwest Technology Assistance Center
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Groundwater Availability at Griggsville, Illinois (Pike County) [PDF]
, 2008 This project is an outgrowth of the Public Service Program of the Center for Groundwater Science (CGS) at the Illinois State Water Survey. For over 50 years, the CGS has provided groundwater information to any requesting individual, commercial facility ...
Midwest Technology Assistance Center
core