Results 61 to 70 of about 11,016,682 (343)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Disorders of water balance [PDF]
Clinical Medicine, 2003 Water homeostasis is maintained by the balance between fluid intake (governed by thirst) and water excretion (controlled by arginine vasopressin (AVP)) With the exception of secondary nephrogenic diabetes imsipidus (DI), polyuric states caused by disorders of thirst, cranial DI and renal resistance to AVP (nephrogenic DI) are uncommon Hyponatraemia is ...
Kevin, Moore +2 more
openaire +2 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
International Soil and Water Conservation Research, 2018 To use water resources sustainably, it is important to understand the quantity of water resource spatially and temporally. Therefore, the work presented here attempts to preface future modeling applications within a watershed in North Carolina, by ...
Frederick Ayivi, M. Jha
semanticscholar +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Revista Facultad de Ingeniería Universidad de Antioquia, 2014 The Wetland “ciénaga de Cachimbero”, located in the municipality of Cimitarra, Santander, has ecological and environmental importance for the region. It has been inventoried by the Ministry of the Environment and been catalogued as Palustral. A combined
Nelson Molina Giraldo +2 more
doaj +1 more source
Effect of different cover crop residue management practices on soil moisture content under a tomato crop (Lycopersicon esculentum) [PDF]
, 2014 Water relations are among the most important physical phenomena that affect the use of soils for agricultural, ecological, environmental, and engineering purposes.
Cornelis, Wim +4 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source